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Name | Vasopressin V2 receptor |
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Species | Homo sapiens (Human) |
Gene | AVPR2 |
Synonym | AVPR V2 antidiuretic hormone receptor Renal-type arginine vasopressin receptor DIR3 ADHR [ Show all ] |
Disease | Euvolemic hyponatremia; Hypervolemic hyponatremia Enuresis; Polyuria; Diabetes insipidus Hypervolaemic hyponatraemia; Euvolaemic hyponatraemia Congestive heart failure Heart failure [ Show all ] |
Length | 371 |
Amino acid sequence | MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGPSERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTTASSSLAKDTSS |
UniProt | P30518 |
Protein Data Bank | N/A |
GPCR-HGmod model | P30518 |
3D structure model | This predicted structure model is from GPCR-EXP P30518. |
BioLiP | N/A |
Therapeutic Target Database | T66237 |
ChEMBL | CHEMBL1790 |
IUPHAR | 368 |
DrugBank | BE0000293 |
Name | CHEMBL448195 |
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Molecular formula | C32H25Cl2F2N5O2 |
IUPAC name | (2Z)-2-[1-(2-chloro-4-indazol-2-ylbenzoyl)-4,4-difluoro-2,3-dihydro-1-benzazepin-5-ylidene]-N-(pyridin-2-ylmethyl)acetamide;hydrochloride |
Molecular weight | 620.482 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 2 |
XlogP | None |
Synonyms | N/A |
Inchi Key | ANHXYECCKPTHFF-ZVOSEVRTSA-N |
Inchi ID | InChI=1S/C32H24ClF2N5O2.ClH/c33-27-17-23(40-20-21-7-1-3-10-28(21)38-40)12-13-25(27)31(42)39-16-14-32(34,35)26(24-9-2-4-11-29(24)39)18-30(41)37-19-22-8-5-6-15-36-22;/h1-13,15,17-18,20H,14,16,19H2,(H,37,41);1H/b26-18-; |
PubChem CID | 44589892 |
ChEMBL | CHEMBL448195 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. Partition coefficient log P of this ligand is not available. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Activity | 8.7 % | PMID18835174 | ChEMBL |
EC50 | <10000.0 nM | PMID18835174 | ChEMBL |
Ki | 20.0 nM | PMID18835174 | ChEMBL |
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