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GPCR

NameMetabotropic glutamate receptor 1
SpeciesHomo sapiens (Human)
GeneGRM1
SynonymSCAR13
MGLUR1
mGlu1 receptor
metabotropic glutamate receptor 1
GPRC1A
[ Show all ]
DiseaseAlzheimer disease; Huntington's disease
Neurological disease
Neuropathic pain
Schizophrenia
Pain
Length1194
Amino acid sequenceMVGLLLFFFPAIFLEVSLLPRSPGRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPDGQSLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKAGAGNANSNGKSVSWSEPGGGQVPKGQHMWHRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDTSTKTLYNVEEEEDAQPIRFSPPGSPSMVVHRRVPSAATTPPLPSHLTAEETPLFLAEPALPKGLPPPLQQQQQPPPQQKSLMDQLQGVVSNFSTAIPDFHAVLAGPGGPGNGLRSLYPPPPPPQHLQMLPLQLSTFGEELVSPPADDDDDSERFKLLQEYVYEHEREGNTEEDELEEEEEDLQAASKLTPDDSPALTPPSPFRDSVASGSSVPSSPVSESVLCTPPNVSYASVILRDYKQSSSTL
UniProtQ13255
Protein Data Bank4or2, 3ks9
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 4or2.
BioLiPBL0271871,BL0271876, BL0271872,BL0271873,BL0271874,, BL0174211,BL0174213, BL0174210,BL0174212
Therapeutic Target DatabaseT27137
ChEMBLCHEMBL3772
IUPHAR289
DrugBankBE0000824

Ligand

NameCHEMBL1098805
Molecular formulaC22H16N2OS
IUPAC name5-(2-methyl-1,3-benzothiazol-5-yl)-2-phenylmethoxybenzonitrile
Molecular weight356.443
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP5.6
Synonyms2-Benzoxy-5-(2-methylbenzo[d]thiazol-5-yl)benzonitrile
BDBM50317847
Inchi KeyGGOPQZHINXTGIV-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H16N2OS/c1-15-24-20-12-18(8-10-22(20)26-15)17-7-9-21(19(11-17)13-23)25-14-16-5-3-2-4-6-16/h2-12H,14H2,1H3
PubChem CID46888043
ChEMBLCHEMBL1098805
IUPHARN/A
BindingDB50317847
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition>50.0 %PMID20382541ChEMBL

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