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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Homo sapiens (Human)
Gene	HTR4
Synonym	5-HT-4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 5-HT4 receptor 5-HT4 serotonin receptor 4
Disease	N/A
Length	388
Amino acid sequence	MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT
UniProt	Q13639
Protein Data Bank	N/A
GPCR-HGmod model	Q13639
3D structure model	This predicted structure model is from GPCR-EXP Q13639.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1875
IUPHAR	9
DrugBank	BE0000084

Ligand

Name	CHEMBL2179686
Molecular formula	C23H28Cl2N4O
IUPAC name	N-[[1-[2-(4-chlorophenyl)ethyl]piperidin-4-yl]methyl]-1-methylindazole-3-carboxamide;hydrochloride
Molecular weight	447.404
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	None
Synonyms	N/A
Inchi Key	ANICRASVXRCEFJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H27ClN4O.ClH/c1-27-21-5-3-2-4-20(21)22(26-27)23(29)25-16-18-11-14-28(15-12-18)13-10-17-6-8-19(24)9-7-17;/h2-9,18H,10-16H2,1H3,(H,25,29);1H
PubChem CID	71460948
ChEMBL	CHEMBL2179686
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	31.0 %	PMID23043420	ChEMBL
Inhibition	80.0 %	PMID23043420	ChEMBL
Inhibition	105.0 %	PMID23043420	ChEMBL

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