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GPCR

NameMu-type opioid receptor
SpeciesRattus norvegicus (Rat)
GeneOprm1
SynonymOpioid receptor B
opioid receptor
OP3
mu receptor
MOR-1
[ Show all ]
DiseaseN/A for non-human GPCRs
Length398
Amino acid sequenceMDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
UniProtP33535
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL270
IUPHAR319
DrugBankN/A

Ligand

NameCHEMBL161512
Molecular formulaC18H22N2O2
IUPAC nameN-[1-(2-phenylethyl)piperidin-4-yl]furan-2-carboxamide
Molecular weight298.386
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP3.1
SynonymsSCHEMBL17512173
BDBM50017418
Furan-2-carboxylic acid (1-phenethyl-piperidin-4-yl)-amide
Inchi KeyANKJEEDQRYNCTR-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H22N2O2/c21-18(17-7-4-14-22-17)19-16-9-12-20(13-10-16)11-8-15-5-2-1-3-6-15/h1-7,14,16H,8-13H2,(H,19,21)
PubChem CID35121669
ChEMBLCHEMBL161512
IUPHARN/A
BindingDB50017418
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki<100.0 nMPMID2563773BindingDB,ChEMBL

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