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GPCR

NameHistamine H4 receptor
SpeciesRattus norvegicus (Rat)
GeneHrh4
SynonymGPCR105
H4 receptor
H4R
HH4R
DiseaseN/A for non-human GPCRs
Length391
Amino acid sequenceMSESNGTDVLPLTAQVPLAFLMSLLAFAITIGNAVVILAFVADRNLRHRSNYFFLNLAISDFFVGVISIPLYIPHTLFNWNFGSGICMFWLITDYLLCTASVYSIVLISYDRYQSVSNAVRYRAQHTGILKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTEECEPGFVTEWYILAITAFLEFLLPVSLVVYFSVQIYWSLWKRGSLSRCPSHAGFIATSSRGTGHSRRTGLACRTSLPGLKEPAASLHSESPRGKSSLLVSLRTHMSGSIIAFKVGSFCRSESPVLHQREHVELLRGRKLARSLAVLLSAFAICWAPYCLFTIVLSTYRRGERPKSIWYSIAFWLQWFNSLINPFLYPLCHRRFQKAFWKILCVTKQPAPSQTQSVSS
UniProtQ91ZY1
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4468
IUPHAR265
DrugBankN/A

Ligand

NameCHEMBL506187
Molecular formulaC14H25N5
IUPAC name4-tert-butyl-6-(4-ethylpiperazin-1-yl)pyrimidin-2-amine
Molecular weight263.389
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP2.2
SynonymsSCHEMBL2167751
Inchi KeyGHFPIOBFRSDFOH-UHFFFAOYSA-N
Inchi IDInChI=1S/C14H25N5/c1-5-18-6-8-19(9-7-18)12-10-11(14(2,3)4)16-13(15)17-12/h10H,5-9H2,1-4H3,(H2,15,16,17)
PubChem CID25128826
ChEMBLCHEMBL506187
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50245.47 nMPMID18811133ChEMBL
Efficacy55.0 %PMID18811133ChEMBL

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