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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Lysophosphatidic acid receptor 3
Species	Homo sapiens (Human)
Gene	LPAR3
Synonym	Lysophosphatidic acid receptor Edg-7 LPA3 receptor LPA-3 LPA receptor 3 endothelial differentiation gene 7, lysophosphatidic acid G-protein-coupled receptor 7 Edg7 [ Show all ]
Disease	Fibrosis
Length	353
Amino acid sequence	MNECHYDKHMDFFYNRSNTDTVDDWTGTKLVIVLCVGTFFCLFIFFSNSLVIAAVIKNRKFHFPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVNRWFLRQGLLDSSLTASLTNLLVIAVERHMSIMRMRVHSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLAPIYSRSYLVFWTVSNLMAFLIMVVVYLRIYVYVKRKTNVLSPHTSGSISRRRTPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGLNCRQCGVQHVKRWFLLLALLNSVVNPIIYSYKDEDMYGTMKKMICCFSQENPERRPSRIPSTVLSRSDTGSQYIEDSISQGAVCNKSTS
UniProt	Q9UBY5
Protein Data Bank	N/A
GPCR-HGmod model	Q9UBY5
3D structure model	This predicted structure model is from GPCR-EXP Q9UBY5.
BioLiP	N/A
Therapeutic Target Database	T95923
ChEMBL	CHEMBL3250
IUPHAR	274
DrugBank	N/A

Ligand

Name	CHEMBL2182057
Molecular formula	C19H17ClFN3O2
IUPAC name	1-(2-chlorophenyl)ethyl N-[4-(4-fluorophenyl)-2-methylpyrazol-3-yl]carbamate
Molecular weight	373.812
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	4.4
Synonyms	BDBM50398107 SCHEMBL17077088
Inchi Key	GHHHFOOMBYUUEO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H17ClFN3O2/c1-12(15-5-3-4-6-17(15)20)26-19(25)23-18-16(11-22-24(18)2)13-7-9-14(21)10-8-13/h3-12H,1-2H3,(H,23,25)
PubChem CID	71461124
ChEMBL	CHEMBL2182057
IUPHAR	N/A
BindingDB	50398107
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<30000.0 nM	PMID22894757	BindingDB,ChEMBL

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