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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Melanin-concentrating hormone receptor 2
Species	Homo sapiens (Human)
Gene	MCHR2
Synonym	G-protein coupled receptor 145 melanin-concentrating hormone receptor 2 MCHR-2 MCH2R MCH2 receptor MCH2 G protein-coupled receptor 145 MCH-2R MCH receptor 2 GPRv17 GPR145 MCH-R2 [ Show all ]
Disease	N/A
Length	340
Amino acid sequence	MNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
UniProt	Q969V1
Protein Data Bank	N/A
GPCR-HGmod model	Q969V1
3D structure model	This predicted structure model is from GPCR-EXP Q969V1.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5038
IUPHAR	281
DrugBank	N/A

Ligand

Name	CHEMBL197280
Molecular formula	C27H26Cl2N4O
IUPAC name	1-[[4-(3-cyanophenyl)phenyl]methyl]-3-(3,5-dichlorophenyl)-1-(2-pyrrolidin-1-ylethyl)urea
Molecular weight	493.432
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	5.7
Synonyms	BDBM50174822 1-(3''-cyano-biphenyl-4-ylmethyl)-3-(3,5-dichloro-phenyl)-1-(2-pyrrolidin-1-yl-ethyl)-urea
Inchi Key	GIOCKCZZIGNDMZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H26Cl2N4O/c28-24-15-25(29)17-26(16-24)31-27(34)33(13-12-32-10-1-2-11-32)19-20-6-8-22(9-7-20)23-5-3-4-21(14-23)18-30/h3-9,14-17H,1-2,10-13,19H2,(H,31,34)
PubChem CID	44405437
ChEMBL	CHEMBL197280
IUPHAR	N/A
BindingDB	50174822
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<3000.0 nM	PMID16202583	BindingDB,ChEMBL

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