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Name | D(2) dopamine receptor |
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Species | Homo sapiens (Human) |
Gene | DRD2 |
Synonym | dopamine receptor 2 Dopamine D2 receptor D2R D2A and D2B D2(415) and D2(444) [ Show all ] |
Disease | Substance dependence Major depressive disorder Maintain blood pressure in hypotensive states Insomnia Inflammatory disease [ Show all ] |
Length | 443 |
Amino acid sequence | MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC |
UniProt | P14416 |
Protein Data Bank | 6cm4, 6c38 |
GPCR-HGmod model | P14416 |
3D structure model | This structure is from PDB ID 6cm4. |
BioLiP | BL0408379, BL0403379 |
Therapeutic Target Database | T67162 |
ChEMBL | CHEMBL217 |
IUPHAR | 215 |
DrugBank | BE0000756 |
Name | CHEMBL241424 |
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Molecular formula | C30H33N3O2 |
IUPAC name | N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]-4-(2-phenylethynyl)benzamide |
Molecular weight | 467.613 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 5.5 |
Synonyms | BDBM50221663 N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-4-phenylethynylbenzamide |
Inchi Key | GJRMDYLDWDRDIG-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C30H33N3O2/c1-35-29-12-6-5-11-28(29)33-23-21-32(22-24-33)20-8-7-19-31-30(34)27-17-15-26(16-18-27)14-13-25-9-3-2-4-10-25/h2-6,9-12,15-18H,7-8,19-24H2,1H3,(H,31,34) |
PubChem CID | 44436601 |
ChEMBL | CHEMBL241424 |
IUPHAR | N/A |
BindingDB | 50221663 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Activity | 4.0 % | PMID17827018 | ChEMBL |
Activity | 14.0 % | PMID17827018 | ChEMBL |
Ki | 190.0 nM | PMID17827018 | BindingDB,ChEMBL |
Ki | 1400.0 nM | PMID17827018 | BindingDB,ChEMBL |
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