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Name | Histamine H2 receptor |
---|---|
Species | Homo sapiens (Human) |
Gene | HRH2 |
Synonym | HH2R H2R Gastric receptor I H2 receptor |
Disease | Ulcerative colitis Pain Peptic ulcer Gastroesophageal reflux disease Gastric ulcer [ Show all ] |
Length | 359 |
Amino acid sequence | MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR |
UniProt | P25021 |
Protein Data Bank | N/A |
GPCR-HGmod model | P25021 |
3D structure model | This predicted structure model is from GPCR-EXP P25021. |
BioLiP | N/A |
Therapeutic Target Database | T30985 |
ChEMBL | CHEMBL1941 |
IUPHAR | 263 |
DrugBank | BE0000112 |
Name | CHEMBL194837 |
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Molecular formula | C22H23Cl2N3O3 |
IUPAC name | 2-(2,4-dichlorophenoxy)-N-[2-[2-(dimethylamino)ethoxy]-4-methylquinolin-6-yl]acetamide |
Molecular weight | 448.344 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 1 |
XlogP | 5.0 |
Synonyms | BDBM50172414 SCHEMBL5910613 2-(2,4-Dichloro-phenoxy)-N-[2-(2-dimethylamino-ethoxy)-4-methyl-quinolin-6-yl]-acetamide |
Inchi Key | GKDBTHSYQZTDAJ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C22H23Cl2N3O3/c1-14-10-22(29-9-8-27(2)3)26-19-6-5-16(12-17(14)19)25-21(28)13-30-20-7-4-15(23)11-18(20)24/h4-7,10-12H,8-9,13H2,1-3H3,(H,25,28) |
PubChem CID | 11539632 |
ChEMBL | CHEMBL194837 |
IUPHAR | N/A |
BindingDB | 50172414 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 0.87 nM | PMID16134937 | BindingDB,ChEMBL |
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