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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	5-hydroxytryptamine receptor 1D
Species	Sus scrofa (Pig)
Gene	HTR1D
Synonym	5-HT-1D 5-HT1D Serotonin receptor 1D
Disease	N/A for non-human GPCRs
Length	291
Amino acid sequence	AMTDLLVSILVMPISIPYTITQTWSFGQLLCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAIVWAISICISIPPLFWRQARAHEEISDCLVNTSQISYTIYSTCGAFYIPSLLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNPSLHEGHSHSAGSPLFFNHVKIKLADSVLERKRISAARERKATKTLGIILGAFIICWLPFFVASLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKVV
UniProt	P79400
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL54265
Molecular formula	C14H17N5
IUPAC name	N,N-dimethyl-2-[5-(1,2,4-triazol-1-yl)-1H-indol-3-yl]ethanamine
Molecular weight	255.325
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	1.3
Synonyms	SCHEMBL8783731 BDBM50407356 N,N-Dimethyl-5-(1H-1,2,4-triazol-1-yl)-1H-indole-3-(ethanamine)
Inchi Key	GKKAQRFMUGUZQS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H17N5/c1-18(2)6-5-11-8-16-14-4-3-12(7-13(11)14)19-10-15-9-17-19/h3-4,7-10,16H,5-6H2,1-2H3
PubChem CID	10106412
ChEMBL	CHEMBL54265
IUPHAR	N/A
BindingDB	50407356
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	19.95 nM	PMID7752204	BindingDB,ChEMBL
IC50	20.0 -	Bioorg. Med. Chem. Lett., (1996) 6:15:1825	ChEMBL
IC50	20.0 nM	N/A	BindingDB

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