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GPCR

NameTrace amine-associated receptor 7b
SpeciesRattus norvegicus (Rat)
GeneTaar7b
SynonymTaR-12
Trace amine receptor 12
Trace amine receptor 7b
TaR-7b
DiseaseN/A for non-human GPCRs
Length358
Amino acid sequenceMATDDDRFPWDQDSILSRDLLSASSMQLCYEKLNRSCVRSPYSPGPRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMPFSMVRSVEGCWYFGDIYCKFHSSFDGSFCYSSIFHLCFISADRYIAVSDPLIYPTRFTASVSGKCITFSWLLSIIYSFSLFYTGVNEAGLEDLVSALTCVGGCQIAVNQSWVFINFLLFLVPALVMMTVYSKIFLIAKQQAQNIEKMGKQTARASESYKDRVAKRERKAAKTLGIAVAAFLLSWLPYFIDSIIDAFLGFVTPTYVYEILVWIGYYNSAMNPLIYAFFYPWFRKAIKLIVTGKILRENSSATNLFPE
UniProtQ923X8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2176813
IUPHARN/A
DrugBankN/A

Ligand

NameUS8802673, 167
Molecular formulaC16H17F3N4O
IUPAC nameN-[2-methyl-4-[(2S)-morpholin-2-yl]phenyl]-5-(trifluoromethyl)pyrimidin-2-amine
Molecular weight338.334
Hydrogen bond acceptor8
Hydrogen bond donor2
XlogP2.4
SynonymsBDBM6773
CHEMBL3641767
SCHEMBL12609658
Inchi KeyGKWCGXQJLPLVMD-CQSZACIVSA-N
Inchi IDInChI=1S/C16H17F3N4O/c1-10-6-11(14-9-20-4-5-24-14)2-3-13(10)23-15-21-7-12(8-22-15)16(17,18)19/h2-3,6-8,14,20H,4-5,9H2,1H3,(H,21,22,23)/t14-/m1/s1
PubChem CID68325452
ChEMBLCHEMBL3641767
IUPHARN/A
BindingDB6773
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki1353.9 nM, NoneBindingDB,ChEMBL

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