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GPCR

NameNociceptin receptor
SpeciesMus musculus (Mouse)
GeneOprl1
SynonymNOP receptor
NOP-r
NOPr
OP4
ORGC
[ Show all ]
DiseaseN/A for non-human GPCRs
Length367
Amino acid sequenceMESLFPAPFWEVLYGSHFQGNLSLLNETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALHREMQVSDRVRSIAKDVGLGCKTSETVPRPA
UniProtP35377
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3621
IUPHAR320
DrugBankN/A

Ligand

NameCHEMBL265544
Molecular formulaC62H99F3N22O15
IUPAC name(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-[4-(trifluoromethyl)phenyl]propanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Molecular weight1449.61
Hydrogen bond acceptor23
Hydrogen bond donor22
XlogP-6.1
SynonymsPhe-Gly-Gly-4-(Trifluoromethyl)-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-NH2
Inchi KeyGLDGRWBNRWZUQW-QHYQKCGXSA-N
Inchi IDInChI=1S/C62H99F3N22O15/c1-33(79-47(91)31-78-59(102)49(35(3)89)87-57(100)44(28-37-19-21-38(22-20-37)62(63,64)65)81-48(92)30-76-46(90)29-77-53(96)39(68)27-36-13-5-4-6-14-36)51(94)83-43(18-12-26-75-61(72)73)55(98)85-41(16-8-10-24-67)56(99)86-45(32-88)58(101)80-34(2)52(95)84-42(17-11-25-74-60(70)71)54(97)82-40(50(69)93)15-7-9-23-66/h4-6,13-14,19-22,33-35,39-45,49,88-89H,7-12,15-18,23-32,66-68H2,1-3H3,(H2,69,93)(H,76,90)(H,77,96)(H,78,102)(H,79,91)(H,80,101)(H,81,92)(H,82,97)(H,83,94)(H,84,95)(H,85,98)(H,86,99)(H,87,100)(H4,70,71,74)(H4,72,73,75)/t33-,34-,35+,39-,40-,41-,42-,43-,44-,45-,49-/m0/s1
PubChem CID11007770
ChEMBLCHEMBL265544
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Emax-75.0 %PMID11689082ChEMBL
Ki1.0 nMPMID11689082ChEMBL

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