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GPCR

NameHistamine H4 receptor
SpeciesRattus norvegicus (Rat)
GeneHrh4
SynonymH4 receptor
H4R
HH4R
GPCR105
DiseaseN/A for non-human GPCRs
Length391
Amino acid sequenceMSESNGTDVLPLTAQVPLAFLMSLLAFAITIGNAVVILAFVADRNLRHRSNYFFLNLAISDFFVGVISIPLYIPHTLFNWNFGSGICMFWLITDYLLCTASVYSIVLISYDRYQSVSNAVRYRAQHTGILKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTEECEPGFVTEWYILAITAFLEFLLPVSLVVYFSVQIYWSLWKRGSLSRCPSHAGFIATSSRGTGHSRRTGLACRTSLPGLKEPAASLHSESPRGKSSLLVSLRTHMSGSIIAFKVGSFCRSESPVLHQREHVELLRGRKLARSLAVLLSAFAICWAPYCLFTIVLSTYRRGERPKSIWYSIAFWLQWFNSLINPFLYPLCHRRFQKAFWKILCVTKQPAPSQTQSVSS
UniProtQ91ZY1
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4468
IUPHAR265
DrugBankN/A

Ligand

NameCHEMBL492227
Molecular formulaC14H18N6
IUPAC name4-(4-methylpiperazin-1-yl)-6-pyridin-3-ylpyrimidin-2-amine
Molecular weight270.34
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP0.7
SynonymsSCHEMBL2166851
Inchi KeyGLIDZETXCIJSCV-UHFFFAOYSA-N
Inchi IDInChI=1S/C14H18N6/c1-19-5-7-20(8-6-19)13-9-12(17-14(15)18-13)11-3-2-4-16-10-11/h2-4,9-10H,5-8H2,1H3,(H2,15,17,18)
PubChem CID25131555
ChEMBLCHEMBL492227
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50208.93 nMPMID18811133ChEMBL
Efficacy70.0 %PMID18811133ChEMBL

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