Zhang Lab

University of Michigan

Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only

Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●DMFold ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
Go back to previous page.

GPCR

Name	Prostaglandin D2 receptor 2
Species	Homo sapiens (Human)
Gene	PTGDR2
Synonym	CD294 prostaglandin D2 receptor 2 PGD2 receptor Gpr44 G-protein coupled receptor 44 G protein-coupled receptor 44 DP2 receptor CRTH2 Chemoattractant receptor-homologous molecule expressed on Th2 cells [ Show all ]
Disease	Asthma; Chronic obstructive pulmonary disease Asthma Allergy Allergic rhinitis Allergic asthma Respiratory disease [ Show all ]
Length	395
Amino acid sequence	MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCRMRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRIMCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRRPGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRPEEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
UniProt	Q9Y5Y4
Protein Data Bank	6d27, 6d26
GPCR-HGmod model	Q9Y5Y4
3D structure model	This structure is from PDB ID 6d27.
BioLiP	BL0428440, BL0428439
Therapeutic Target Database	T61722
ChEMBL	CHEMBL5071
IUPHAR	339
DrugBank	BE0003561

Ligand

Name	2-Formylphenoxyacetic acid
Molecular formula	C9H8O4
IUPAC name	2-(2-formylphenoxy)acetic acid
Molecular weight	180.159
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	0.8
Synonyms	H2854 NSC 133590 o-Formyphenoxyacetic acid Z1608 2-(2-Formylphenoxy)acetic acid 6280-80-4 acide formyl-2 phenoxyacetique CS-M3473 KB-170527 NSC-6140 SCHEMBL354835 Acetic acid, (2-formylphenoxy)- ANWMNLAAFDCKMT-UHFFFAOYSA-N DB-054295 MFCD00003315 o-formyl phenoxyacetic acid STK346861 (o-Formyl-phenoxy)acetic acid 2-monoformylphenoxyacetic acid Acetic acid,2-(2-formylphenoxy)- FR-1038 I04-9096 NSC 6140 ortho-Formylphenoxyacetic acid ZINC562681 2-Carboxymethoxybenzaldehyde AC1L2G6R AE-848/00904006 CTK5B6136 KS-00001DQE NSC133590 SP655 2-Formylphenoxyacetic acid, 97% Acetic acid, (o-formylphenoxy)- BBL009148 DTXSID3064196 FT-0608808 MolPort-000-869-440 o-Formylphenoxyacetic acid TR-021603 1636898-57-1 Aceticacid,(2-formylphenoxy)- CHEMBL384289 Integrase inhibitor, R2{3} NSC-133590 SBB008189 2-formyl phenoxyacetic acid AC1Q764B AKOS000113319 D0J2PW MCULE-7880702668 NSC6140 ST45137541 (2-Formylphenoxy)acetic acid 2-Formylphenoxyaceticacid Acetic acid, 2-(2-formylphenoxy)- BDBM50200248 EINECS 228-480-9 [ Show all ]
Inchi Key	ANWMNLAAFDCKMT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H8O4/c10-5-7-3-1-2-4-8(7)13-6-9(11)12/h1-5H,6H2,(H,11,12)
PubChem CID	46533
ChEMBL	CHEMBL384289
IUPHAR	N/A
BindingDB	50200248
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1970.0 nM	PMID17154491	BindingDB,ChEMBL
IC50	50000.0 nM	PMID17154491	BindingDB,ChEMBL

zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218