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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameMetabotropic glutamate receptor 8
SpeciesHomo sapiens (Human)
GeneGRM8
SynonymGprc1h
glutamate receptor
mGluR8b
GLUR8
mGlu8 receptor
[ Show all ]
DiseaseN/A
Length908
Amino acid sequenceMVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTYISYSNHSI
UniProtO00222
Protein Data Bank6bsz, 6bt5, 6e5v
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 6bsz.
BioLiPBL0403876,BL0403877, BL0403874,BL0403875, BL0432251,BL0432252
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3228
IUPHAR296
DrugBankBE0000835

Known ligands

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Total entries: 156
Page:  / 2 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
49462D structureCHEMBL1099113C23H16N2320.3952 / 05.6No
5361422D structureCHEMBL3899832C22H19N5O4417.4258 / 23.6Yes
82632D structureCHEMBL2208408C15H15ClN2O3S338.8064 / 12.6Yes
104002D structureCHEMBL2426616C14H14N2O2S274.3384 / 02.3Yes
114852D structureCHEMBL2381648C10H14N2O5242.2316 / 4-4.2Yes
114892D structureCHEMBL2381649C10H14N2O5242.2316 / 4-4.2Yes
129032D structureVU 0361737C13H11ClN2O2262.6933 / 12.6Yes
152062D structure635318-11-5C7H9NO6S235.217 / 3-4.8Yes
160032D structureCHEMBL300330C7H12N2O4188.1836 / 3-6.0Yes
203112D structureCHEMBL319279C28H27NO5457.5266 / 32.1Yes
4653742D structureAC1N2AWGC24H24N2O4S436.5265 / 14.1Yes
244522D structureCHEMBL2381647C8H12N2O4200.1946 / 4-6.7Yes
244542D structureCHEMBL2381646C8H12N2O4200.1946 / 4-6.7Yes
307092D structureCHEMBL365368C9H13NO4199.2065 / 3-2.8Yes
307122D structureLY 395756C9H13NO4199.2065 / 3-2.8Yes
4666882D structureCHEMBL3560146C24H24N2O5420.4655 / 13.5Yes
354242D structureCHEMBL418462C13H15ClN2O4298.7236 / 3-3.9Yes
357442D structureCHEMBL1099112C17H11ClN2278.7392 / 04.6Yes
357912D structureBDBM50388941C16H13N3O3295.2985 / 11.4Yes
5534292D structureCID 57689797C3H8NO6P185.0726 / 3-4.5Yes
4674952D structureCHEMBL3605296C20H17N5O3375.3886 / 12.1Yes
5228772D structureCHEMBL3746457C18H15FN4O2338.3425 / 02.2Yes
482952D structureCHEMBL180822C7H11NO5189.1676 / 4-4.2Yes
4692652D structureCHEMBL3628115C19H12ClN3O4381.7725 / 12.6Yes
531382D structureCHEMBL1688377C18H25N3OS331.4784 / 03.3Yes
4699482D structureCHEMBL3628112C20H12Cl2N2O4415.2264 / 14.3Yes
5535232D structureD-AP4C4H10NO5P183.16 / 4-5.5Yes
572752D structure2-amino-4-phosphonobutanoic acidC4H10NO5P183.16 / 4-5.5Yes
572952D structureL-AP4C4H10NO5P183.16 / 4-5.5Yes
610302D structureCHEMBL1099115C22H15N3321.3833 / 04.5Yes
611632D structureCHEMBL334014C8H10FNO4203.1696 / 3-3.2Yes
4709502D structureCHEMBL3560746C23H25NO3S395.5174 / 05.4No
4710172D structureCHEMBL3561387C23H23F2NO3S431.4986 / 05.9No
700612D structureCHEMBL541754C13H10F2N2O2264.2325 / 12.9Yes
706782D structureLY307452C21H25NO4355.4345 / 31.4Yes
753192D structureCHEMBL1096196C16H10ClN3279.7273 / 03.8Yes
792082D structureBDBM86213C13H13NO4247.255 / 01.5Yes
806552D structureCHEMBL1783985C15H25NO235.3711 / 03.4Yes
4733242D structureCHEMBL3561819C24H25NO3S407.5284 / 05.2No
894722D structureCPCCOEtC13H13NO4247.255 / 11.9Yes
958852D structureCHEMBL1098805C22H16N2OS356.4434 / 05.6No
4747652D structureCHEMBL3560922C24H23NO6421.4496 / 04.1Yes
964752D structure2-(m-tolylethynyl)pyrimidineC13H10N2194.2372 / 02.6Yes
5537742D structureD0N9UZC12H13N5O6323.2658 / 5-4.7Yes
1078522D structureCHEMBL1098212C16H9F3N2O3S2398.3749 / 04.9Yes
1093062D structure(2S,1'S,2'S)-2-(carboxycyclopropyl)glycineC6H9NO4159.1415 / 3-3.4Yes
4770812D structureCHEMBL3628113C20H12ClFN2O4398.7745 / 13.8Yes
5248722D structureCHEMBL3804846C22H14F2N2O2376.3635 / 13.9Yes
1198052D structureCHEMBL319732C26H31NO5437.5366 / 32.9Yes
1201972D structureCHEMBL1096811C19H16N2O2304.3494 / 03.9Yes
1202192D structureCHEBI:75204C8H9NO4183.1634 / 3-1.8Yes
1308352D structureCHEMBL59830C8H14N2O4202.216 / 3-5.7Yes
1335932D structureCHEMBL61281C17H18N2O4314.3416 / 3-3.3Yes
5539552D structure(S)-3,4-DCPGC10H9NO6239.1837 / 4-2.7Yes
1374602D structureCHEMBL1098228C24H18N2O350.4213 / 05.4No
4805992D structureAC1P03JTC18H22N2O2S330.4463 / 12.9Yes
1511492D structureCHEMBL420262C29H37NO5479.6176 / 34.5Yes
4821952D structureCHEMBL3561545C22H21FN2O2S396.484 / 14.3Yes
1582962D structure(RS)-PPGC8H10NO5P231.1446 / 4-3.7Yes
4825812D structureCHEMBL3561788C20H21N3O2S2399.5275 / 14.0Yes
1640812D structureCHEMBL1096844C20H12N2S312.393 / 05.3No
1717152D structureDFMTIC20H18F2N4O368.3885 / 03.4Yes
1796382D structureCHEMBL304919C20H22N2O4354.4066 / 3-2.6Yes
4863542D structureCHEMBL3561539C22H21F2NO3S417.4716 / 05.9No
5633592D structureSIB 1757C12H11N3O213.244 / 13.0Yes
1927072D structureCHEMBL1682820C16H14O3254.2853 / 02.8Yes
1956632D structureCHEMBL40123C19H21NO4327.385 / 30.3Yes
5634992D structureCHEMBL1098211C17H12N2O260.2963 / 14.1Yes
1977602D structure3-((2-fluorothiazol-4-yl)ethynyl)-5-fluorobenzonitrileC12H4F2N2S246.2355 / 03.3Yes
1992112D structure1-Benzyl-APDCC13H16N2O4264.2816 / 3-4.5Yes
2010162D structureDcg-IVC7H9NO6203.157 / 4-4.3Yes
4883572D structureCHEMBL3560239C24H25NO4S423.5275 / 04.8Yes
4883632D structureMLS000335684C22H21FN2O2S396.484 / 14.3Yes
2085492D structure7-(benzyloxy)-2,3-dihydro-4H-chromen-4-oneC16H14O3254.2853 / 02.8Yes
4897032D structureAC1N0VGZC21H26N2O3S386.514 / 12.9Yes
4900172D structureCHEMBL3561870C25H26N2O4S450.5535 / 04.3Yes
2186822D structureCID 70682300C16H13N3O3295.2985 / 21.8Yes
2189482D structureCHEMBL439775C22H23NO5381.4286 / 30.7Yes
2193292D structureCHEMBL1682821C16H12O4268.2684 / 02.8Yes
2213582D structureCHEMBL1096197C22H15N3321.3833 / 04.5Yes
2216452D structureMPEPC14H11N193.2491 / 03.3Yes
4506002D structureCHEMBL3401195C19H16FN3O2337.3544 / 03.1Yes
2299842D structureMTEPC11H8N2S200.2593 / 02.3Yes
2317752D structureCHEMBL330097C8H11NO5201.1786 / 4-3.7Yes
5563972D structureSalvinorin AC23H28O8432.4698 / 02.5Yes
2373382D structureAC1N0WBKC23H28O8432.4698 / 02.5Yes
2373672D structureCHEMBL2381645C8H10N4O4226.1927 / 3-2.7Yes
2373712D structureCHEMBL2381644C8H10N4O4226.1927 / 3-2.7Yes
4926252D structureCHEMBL3560612C23H22F2N2O4428.4366 / 14.6Yes
2464192D structureCHEMBL2381641C9H11NO4197.195 / 3-3.4Yes
5545382D structureMPPGC9H12NO5P245.1716 / 4-3.5Yes
2559632D structureAZD-6538C15H6FN5O291.2457 / 02.0Yes
2618572D structureCHEMBL60008C13H15ClN2O4298.7236 / 3-3.9Yes
2666672D structureCHEMBL1099114C23H15FN2338.3853 / 05.7No
5292382D structureCHEMBL3747116C19H16FN3O2337.3544 / 03.2Yes
2718642D structureCHEMBL218710C7H9NO5S219.2117 / 3-5.1Yes
2733692D structureCHEMBL302411C17H18N2O4314.3416 / 3-3.3Yes
2740922D structureCHEMBL8839C7H9NO4S203.2126 / 3-3.5Yes
2740942D structureCHEMBL88999C7H9NO4S203.2126 / 3-3.5Yes
2751552D structureCHEMBL244585C15H10N2S250.3193 / 04.1Yes

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