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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameAlpha-1A adrenergic receptor
SpeciesOryctolagus cuniculus (Rabbit)
GeneADRA1A
SynonymAlpha-1A adrenoceptor
Alpha-1A adrenoreceptor
Alpha-1C adrenergic receptor
DiseaseN/A for non-human GPCRs
Length466
Amino acid sequenceMVFLSGNASDSSNCTHPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIISLCVISIDRYIGVSYPLRYPTIVTQRRGLRALLCVWAFSLVISVGPLFGWRQPAPDDETICQINEEPGYVLFSALGSFYVPLTIILAMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGVASAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLKIQCLRRKQSSKHALGYTLHAPSQALEGQHKDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPRGSARITVPKDQSACTTARVRSKSFLQVCCCVGPSTPNPGENHQVPTIKIHTISLSENGEEV
UniProtO02824
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3637
IUPHARN/A
DrugBankN/A

Known ligands

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Total entries: 114
Page:  / 2 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
21122D structureCHEMBL91326C24H34N4O2410.5625 / 14.2Yes
36412D structureLASSBio-683C20H25ClN2O3376.8815 / 1N/AN/A
82072D structureBW-723C86C16H18N2OS286.3933 / 23.0Yes
127562D structureCHEMBL327168C24H30N6O2434.5447 / 13.2Yes
135752D structureCHEMBL91989C27H32F3N5O2515.5819 / 15.3No
162762D structureCHEMBL88181C23H31N3O2S413.585 / 03.9Yes
178902D structureBmy-7378C22H31N3O3385.5085 / 02.8Yes
188242D structureLASSBio-724C19H25ClN2316.8732 / 1N/AN/A
265452D structureRauwolscineC21H26N2O3354.454 / 22.9Yes
266162D structureYohimbineC21H26N2O3354.454 / 22.9Yes
286502D structureCHEMBL313775C25H32F3N7O2519.57310 / 24.1No
302512D structureCHEMBL111372C14H17N3O3S307.3685 / 31.4Yes
320312D structureCHEMBL88160C26H34F3N7O2533.610 / 14.3No
361642D structureCHEMBL433348C23H30N4O2394.5196 / 13.8Yes
392152D structureCHEMBL92901C22H31N5O2397.5236 / 23.3Yes
464282D structureLASSBio-773C21H27ClN2O3390.9085 / 1N/AN/A
495992D structureCHEMBL330579C23H30F3N5O2465.5219 / 14.3Yes
536472D structureCHEMBL327351C22H31N5O3413.5227 / 22.8Yes
547762D structureCHEMBL2153423C20H25ClN2O3376.8815 / 1N/AN/A
631542D structurephenylpropanolamineC9H13NO151.2092 / 20.8Yes
669632D structureTAMSULOSINC20H28N2O5S408.5137 / 22.7Yes
709572D structureCHEMBL2261355C15H19N3O2S305.3964 / 22.1Yes
709612D structureCHEMBL111496C15H19N3O2S305.3964 / 22.1Yes
733252D structureCHEMBL314114C22H28F3N5O435.4958 / 14.1Yes
844972D structureCHEMBL327231C27H33FN8O2520.6139 / 13.4No
871852D structureSCHEMBL7097480C14H17N3O2S291.3694 / 21.7Yes
871912D structureCHEMBL111554C14H17N3O2S291.3694 / 21.7Yes
880722D structureCHEMBL111463C15H19N3O2S305.3964 / 11.9Yes
928522D structureCHEMBL90878C27H31ClF3N5O2550.0239 / 15.9No
942522D structureCHEMBL330060C23H32N4O2396.5355 / 13.9Yes
993002D structureCHEMBL89397C27H31FN6O2490.5838 / 14.0Yes
1003572D structureCHEMBL88633C21H30N6O2398.5117 / 12.5Yes
1056862D structureCHEMBL90746C27H33N5O443.5955 / 14.8Yes
1065972D structureCHEMBL314880C26H34N6O446.5995 / 13.9Yes
1092532D structureCHEMBL91951C24H33N5O407.5625 / 14.1Yes
1157392D structure5-MethylurapidilC21H31N5O3401.5116 / 11.9Yes
1208242D structureIDAZOXANC11H12N2O2204.2293 / 10.7Yes
1273312D structureLASSBio-675C21H27ClN2O2374.9094 / 1N/AN/A
1277132D structureEthanesulfonamide, N-[3-(1H-imidazol-4-ylmethyl)-2-methylphenyl]-C13H17N3O2S279.3584 / 21.7Yes
1313722D structureprazosinC19H21N5O4383.4088 / 12.0Yes
1332252D structureCHEMBL329601C22H31N5OS413.5846 / 13.7Yes
1343102D structureCHEMBL329773C23H30ClFN7O2+490.9887 / 24.0Yes
1388992D structureCHEMBL91480C23H33N5O3427.5497 / 13.1Yes
1411712D structureCHEMBL322492C15H19N3O2S305.3964 / 22.3Yes
1434882D structureCHEMBL111682C12H15N3O2S265.3314 / 21.3Yes
1488552D structureCHEMBL91605C25H34FN7O2483.5928 / 13.3Yes
1503442D structureCHEMBL89222C21H30N6O382.5126 / 12.5Yes
4476952D structureSCHEMBL7098572C14H15N3O2S289.3534 / 21.3Yes
1687372D structureCHEMBL89822C29H40F3N7O2575.68110 / 15.6No
1740932D structureCHEMBL323440C15H19N3O2S305.3964 / 22.1Yes
1783962D structureCHEMBL315496C27H33FN6O3508.5988 / 23.1No
1795422D structureCHEMBL327872C23H30N6O2422.5337 / 12.9Yes
1801942D structureCHEMBL88664C21H29N5O2383.4966 / 22.8Yes
1871592D structureCHEMBL91547C23H31FN7O2+456.5467 / 23.4Yes
1882802D structureCHEMBL90869C23H29F3N4O3466.5059 / 13.6Yes
1895432D structureCHEMBL109755C14H19N3O2S293.3854 / 20.8Yes
1900472D structureLASSBio-730C20H27ClN2330.92 / 1N/AN/A
1944662D structureA 61603 HYDROBROMIDEC14H20BrN3O3S390.2965 / 4N/AN/A
1997452D structureCHEMBL111584C15H19N3O2S305.3964 / 11.7Yes
2093282D structureCHEMBL88856C22H28N6O392.5076 / 12.9Yes
2097272D structureUNII-2L5SGH4CVSC22H31N5O2397.5236 / 13.1Yes
2122122D structureAC1NKXXYC17H19N3O281.3592 / 23.3Yes
2143142D structureCHEMBL442394C15H19N3O3S321.3955 / 21.7Yes
2187752D structureCHEMBL111537C16H21N3O2S319.4234 / 22.5Yes
2339592D structureCHEMBL111151C13H15N3O3S293.3415 / 20.9Yes
2380562D structureLASSBio-728C18H23ClN2O318.8453 / 1N/AN/A
2458362D structureCHEMBL420620C22H30FN5O2415.5137 / 13.2Yes
2477092D structureA61603C14H19N3O3S309.3845 / 30.4Yes
2483652D structureLASSBio-670C20H25ClN2O3376.8815 / 1N/AN/A
2544652D structureCHEMBL91278C25H35N5O2437.5886 / 13.9Yes
2583782D structureCHEMBL93054C21H29N5O2383.4966 / 23.0Yes
2608742D structureCHEMBL111771C14H17N3O2S291.3694 / 21.5Yes
2626422D structureCHEMBL88435C22H31N5O381.5245 / 13.5Yes
2831532D structureCHEMBL93736C22H31N5O2397.5236 / 12.8Yes
2849762D structureCHEMBL91338C23H31N3O3397.5195 / 03.3Yes
2885972D structureCHEMBL90287C21H29N5O367.4975 / 13.2Yes
2925452D structureCHEMBL91785C23H33N5O2411.556 / 13.5Yes
2926392D structureCHEMBL89030C24H34N4O2410.5625 / 14.2Yes
3000232D structureCHEMBL108804C14H17N3O3S307.3685 / 31.4Yes
3015372D structureABT-866C12H15N3O2S265.3314 / 21.4Yes
3041122D structurebenalfocinC11H14ClN195.691 / 02.9Yes
3061562D structureCHEMBL91400C24H35N5O409.5785 / 14.5Yes
3086692D structureCHEMBL327232C22H31N5O3413.5227 / 22.8Yes
3170052D structureCHEMBL313157C23H33N5O2411.556 / 13.5Yes
3187702D structureLASSBio-632C20H25ClN2O2360.8824 / 1N/AN/A
3257602D structureCHEMBL109848C15H17N3O255.3212 / 21.9Yes
3392262D structureLASSBio-629C19H23ClN2O3362.8545 / 1N/AN/A
3468352D structureCHEMBL325897C16H19N3O2S317.4074 / 22.3Yes
3481982D structureCHEMBL322082C14H16ClN3O2S325.8114 / 22.3Yes
3492182D structureLASSBio-682C19H22Cl2N2O2381.2974 / 1N/AN/A
3516632D structureterazosinC19H25N5O4387.448 / 11.4Yes
3539482D structure3600-87-1C10H15NO3197.2344 / 20.1Yes
3605152D structureLASSBio-719BC17H21ClN2288.8192 / 1N/AN/A
3628522D structureCHEMBL322042C14H16FN3O2S309.3595 / 21.8Yes
3761992D structureLASSBio-771C18H23ClN2302.8462 / 1N/AN/A
3776082D structureCHEMBL110751C15H14F3N3O309.2925 / 23.0Yes
3836092D structureCHEMBL315785C25H34FN7O2483.5928 / 13.2Yes
3846202D structureCHEMBL88109C25H30N6O2446.5557 / 12.5Yes
3893032D structureCHEMBL328545C28H35N5O457.6225 / 15.1No
3953552D structureRS-17053C24H29ClN2O2412.9583 / 25.5No

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