Home Research Services Publications People Teaching Job Opening Facilities News Forum Lab Only
Online Services

I-TASSER QUARK LOMETS COACH COFACTOR MetaGO MUSTER CEthreader SEGMER FG-MD ModRefiner REMO DEMO SPRING COTH BSpred ANGLOR BSP-SLIM SAXSTER ThreaDom ThreaDomEx EvoDesign GPCR-I-TASSER BindProf BindProfX SSIPe ResQ IonCom STRUM DAMpred

TM-score TM-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE WDL-RF ATPbind DockRMSD DeepMSA

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

You can:

GPCR

NameOrexin receptor type 1
SpeciesHomo sapiens (Human)
GeneHCRTR1
Synonymhypocretin receptor 1
OX1R
Ox1-R
OX1 receptor
Ox-1-R
[ Show all ]
DiseaseInsomnia
Sleep disorders; Insomnia; Substance dependence
Sleep disorders; Insomnia
Length425
Amino acid sequenceMEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
UniProtO43613
Protein Data Bank4zjc, 4zj8
GPCR-HGmod modelO43613
3D structure modelThis structure is from PDB ID 4zjc.
BioLiPBL0339163, BL0339164
Therapeutic Target DatabaseT73482
ChEMBLCHEMBL5113
IUPHAR321
DrugBankBE0005864

Known ligands

You can:

Total entries: 4368
Page:  / 44 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
572D structureCID 44405017C128H211N45O35S2972.4441 / 42-12.2No
2022D structureSCHEMBL1671891C27H24N4OS452.5765 / 04.9Yes
3562D structureCHEMBL3667557C18H19ClN2O3S2410.9315 / 13.6Yes
3582D structureSCHEMBL2026090C26H27FN4O3462.5257 / 03.0Yes
3892D structureCHEMBL3670580C24H27N5OS433.5746 / 04.6Yes
4630322D structureCHEMBL3663396C25H26N2O3402.4944 / 04.9Yes
7292D structureCHEMBL3667561C18H19BrN2O3S2455.3855 / 13.7Yes
5173212D structureSCHEMBL4536874C20H19F4NO5429.3689 / 13.5Yes
8762D structureSCHEMBL1671846C20H21N7O375.4366 / 02.3Yes
5573312D structureSCHEMBL17043222C24H26N4O2402.4985 / 03.2Yes
9262D structureSCHEMBL6924756C26H25N7O451.5346 / 03.9Yes
5359412D structureCHEMBL3893150C22H20FN7O3449.4469 / 03.1Yes
11452D structureMLS001177268C22H22N2O3362.4293 / 23.6Yes
12402D structureSCHEMBL1671969C26H33N7O459.5986 / 04.5Yes
12892D structureCHEMBL3667560C19H21ClN2O3S2424.9585 / 14.0Yes
4631402D structureCHEMBL3659195C22H21FN4O2392.4345 / 03.4Yes
16412D structureSCHEMBL1671936C21H23N7O389.4636 / 02.8Yes
4592462D structureCHEMBL3894723C26H26N6O2454.5346 / 03.8Yes
17312D structureCHEMBL3669566C27H28N4O424.5483 / 14.1Yes
18332D structureCHEMBL3667579C20H24N2O5S404.4816 / 12.8Yes
5359612D structureSCHEMBL4536732C23H24N2O3S408.5165 / 03.8Yes
20272D structureSCHEMBL1671105C27H23FN4O438.5065 / 04.6Yes
5339192D structureCHEMBL3970835C23H23N7O4461.4829 / 02.9Yes
21102D structureSCHEMBL1671801C23H23FN6O418.4767 / 02.9Yes
23942D structureSCHEMBL1673234C22H22FN5O2407.4497 / 03.4Yes
5173302D structureSCHEMBL4536467C23H24N2O3376.4564 / 03.4Yes
5173322D structureSCHEMBL4534799C23H24N2O3376.4564 / 03.4Yes
24222D structureCHEMBL3112601C23H24N2O3376.4564 / 03.4Yes
5359992D structureSCHEMBL4529392C27H24N2OS424.5623 / 05.5No
34582D structureCHEMBL1080571C26H32N4O2432.5684 / 13.9Yes
4592552D structureCHEMBL3909223C26H25FN6O2472.5247 / 03.9Yes
35142D structureCHEMBL3235265C25H26N4O2414.5094 / 13.9Yes
36012D structureSMR000010089C20H20N2O3336.3914 / 13.6Yes
5360122D structureSCHEMBL16464778C24H24N6O4460.4948 / 03.6Yes
37852D structureBDBM79952C20H20N2O6384.3886 / 23.4Yes
5573872D structureSCHEMBL16655666C24H24N6O412.4975 / 14.0Yes
5360162D structureSCHEMBL4541596C22H24N4O3S424.5197 / 03.2Yes
5215522D structureCHEMBL3742398C23H20F2N2O6S490.4788 / 03.7Yes
5360192D structureSCHEMBL16463160C23H18F4N6O3502.4311 / 04.9No
39772D structureSCHEMBL1672410C22H26N4O3394.4756 / 02.8Yes
5360212D structureCHEMBL3985942C23H22FN7O2447.4747 / 02.5Yes
5360242D structureCHEMBL3965933C19H20F3N5O391.3988 / 23.1Yes
40832D structureMLS001072368C23H26N4O374.4883 / 24.1Yes
42552D structureMLS001223988C22H28N2O4S416.5365 / 13.5Yes
5360382D structureSCHEMBL4532006C21H23N5O3393.4476 / 02.0Yes
5173422D structureCHEMBL3704932C23H22F4N6O474.46410 / 14.0Yes
44322D structureCHEMBL3235258C23H23N5O2401.475 / 13.0Yes
44942D structureCHEMBL1771432C19H17F3N4O374.3676 / 23.8Yes
5360532D structureSCHEMBL16463647C23H21ClN6O3464.917 / 04.3Yes
4634642D structureCHEMBL3659205C25H24N6O2440.5076 / 04.0Yes
5360562D structureSCHEMBL4540837C25H25FN2O3420.4845 / 03.8Yes
48982D structureSCHEMBL6925282C25H26FN5O431.5156 / 03.7Yes
5574162D structureSCHEMBL16666146C20H20FN3O4S417.4558 / 23.5Yes
51382D structureCID 44404999C121H209N43O34S2842.3340 / 40-11.4No
5216142D structureCHEMBL3741065C23H19ClN2O4422.8654 / 04.4Yes
5360742D structureSCHEMBL4536986C22H24N4O3392.4595 / 02.4Yes
54572D structureBDBM50140022C94H151N25O252031.3928 / 23-3.4No
55252D structureCHEMBL2381082C27H26F3N3O3S529.5788 / 14.9No
56922D structureCHEMBL469146C23H23N7O413.4856 / 03.6Yes
4592722D structureCHEMBL3974582C23H21F2N7O3481.4649 / 03.2Yes
61122D structureSCHEMBL2027169C25H26N6O426.5245 / 12.5Yes
62922D structureCHEMBL2413512C21H22FN7O407.4537 / 02.9Yes
62942D structureCHEMBL3670630C21H22FN7O407.4537 / 02.9Yes
5360982D structureSCHEMBL16465942C23H21ClN6O3464.917 / 04.3Yes
63202D structureCHEMBL185136C19H20Cl2N2O3395.283 / 24.0Yes
5173522D structureSCHEMBL4536325C20H18ClF4NO3431.8127 / 05.4No
4636402D structureCHEMBL3622428C32H34N4O6S602.7068 / 34.4No
64432D structureCHEMBL2031484C28H27FN4O2S502.6086 / 15.5No
5479672D structureCHEMBL3901510C20H21N5O2S395.4816 / 03.2Yes
5574612D structureSCHEMBL16033642C20H21N5O2S395.4816 / 03.2Yes
65492D structureCHEMBL3649206C19H19FN8O2410.4135 / 10.6Yes
66242D structureCHEMBL524440C20H26N2O4S390.4985 / 03.2Yes
5574712D structureSCHEMBL16446669C21H26N6O2S426.5397 / 13.1Yes
66332D structureCHEMBL2413372C24H22FN3O3S451.5165 / 03.9Yes
5216422D structureCHEMBL3741474C22H19F2N3O6S491.4669 / 02.9Yes
66962D structureCHEMBL182269C24H25N3O3403.4824 / 23.3Yes
5173552D structureCHEMBL3704949C21H24F3N3O2407.4377 / 14.5Yes
68632D structureSCHEMBL1671430C22H22N4OS390.5055 / 03.6Yes
68732D structureCHEMBL2031494C29H27N3O3465.5534 / 24.2Yes
5361152D structureSCHEMBL4536426C25H26N2O3402.4944 / 04.0Yes
70612D structureCHEMBL2381089C25H25F3N4OS486.5578 / 15.8No
5574842D structureSCHEMBL15658462C24H27N3O2389.4994 / 04.7Yes
5361552D structureCHEMBL3910747C21H20F3N7O443.43410 / 22.4Yes
4419892D structureCHEMBL3398471C21H20FN7O2421.4368 / 03.0Yes
4638082D structureCHEMBL3659198C23H21F2N3O2S441.4977 / 04.9Yes
5361652D structureSCHEMBL4534316C20H16F7NO2435.3429 / 05.3No
76392D structureCHEMBL2418838C31H37N3O6547.6527 / 23.7No
5361702D structureSCHEMBL16465387C24H23FN6O2446.4867 / 04.5Yes
76952D structure792173-99-0C17H13N5O2319.3245 / 22.0Yes
77402D structureCHEMBL1272096C17H15N5O3S2401.4598 / 12.4Yes
79042D structureMLS000096514C16H11NO4S2345.3877 / 04.0Yes
4592882D structureCHEMBL3896431C24H21ClN6O2460.9226 / 03.6Yes
81072D structureSCHEMBL1671269C26H23N5O421.5045 / 03.4Yes
5361792D structureSCHEMBL16464245C24H23FN6O3462.4858 / 04.1Yes
82602D structureCHEMBL3113758C21H23F3N2O4424.428 / 03.7Yes
5173612D structureSCHEMBL4534291C20H18ClF4NO4447.8118 / 05.0Yes
5361882D structureSCHEMBL17064033C25H25FN6O3476.5128 / 04.5Yes
84712D structureCHEMBL55270C17H13N5O2319.3245 / 22.3Yes
4639092D structureCHEMBL3585948C22H21ClN4O2408.8865 / 13.6Yes
5339442D structureCHEMBL3922646C22H15F3N4O3S472.44210 / 05.2No

yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218