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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameOrexin receptor type 2
SpeciesHomo sapiens (Human)
GeneHCRTR2
SynonymOx-2-R
OX2 receptor
Ox2-R
OX2R
orexin receptor type 2
[ Show all ]
DiseaseInsomnia
Length444
Amino acid sequenceMSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
UniProtO43614
Protein Data Bank5ws3, 5wqc, 4s0v, 4rnb
GPCR-HGmod modelO43614
3D structure modelThis structure is from PDB ID 5ws3.
BioLiPBL0303710, BL0398950, BL0397818, BL0302679
Therapeutic Target DatabaseT69485
ChEMBLCHEMBL4792
IUPHAR322
DrugBankBE0005865

Known ligands

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Total entries: 4724
Page:  / 48 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
562D structureCID 44405017C128H211N45O35S2972.4441 / 42-12.2No
2012D structureSCHEMBL1671891C27H24N4OS452.5765 / 04.9Yes
3552D structureCHEMBL3667557C18H19ClN2O3S2410.9315 / 13.6Yes
3572D structureSCHEMBL2026090C26H27FN4O3462.5257 / 03.0Yes
3882D structureCHEMBL3670580C24H27N5OS433.5746 / 04.6Yes
4630332D structureCHEMBL3663396C25H26N2O3402.4944 / 04.9Yes
7302D structureCHEMBL3667561C18H19BrN2O3S2455.3855 / 13.7Yes
5197052D structureCHEMBL3954046C21H21N7O2403.4467 / 22.4Yes
5173202D structureSCHEMBL4536874C20H19F4NO5429.3689 / 13.5Yes
8752D structureSCHEMBL1671846C20H21N7O375.4366 / 02.3Yes
5573302D structureSCHEMBL17043222C24H26N4O2402.4985 / 03.2Yes
9272D structureSCHEMBL6924756C26H25N7O451.5346 / 03.9Yes
5359402D structureCHEMBL3893150C22H20FN7O3449.4469 / 03.1Yes
11442D structureMLS001177268C22H22N2O3362.4293 / 23.6Yes
12412D structureSCHEMBL1671969C26H33N7O459.5986 / 04.5Yes
12902D structureCHEMBL3667560C19H21ClN2O3S2424.9585 / 14.0Yes
4631412D structureCHEMBL3659195C22H21FN4O2392.4345 / 03.4Yes
16402D structureSCHEMBL1671936C21H23N7O389.4636 / 02.8Yes
4592452D structureCHEMBL3894723C26H26N6O2454.5346 / 03.8Yes
17322D structureCHEMBL3669566C27H28N4O424.5483 / 14.1Yes
18322D structureCHEMBL3667579C20H24N2O5S404.4816 / 12.8Yes
5359622D structureSCHEMBL4536732C23H24N2O3S408.5165 / 03.8Yes
20262D structureSCHEMBL1671105C27H23FN4O438.5065 / 04.6Yes
5339182D structureCHEMBL3970835C23H23N7O4461.4829 / 02.9Yes
21112D structureSCHEMBL1671801C23H23FN6O418.4767 / 02.9Yes
23932D structureSCHEMBL1673234C22H22FN5O2407.4497 / 03.4Yes
5173292D structureSCHEMBL4536467C23H24N2O3376.4564 / 03.4Yes
5173312D structureSCHEMBL4534799C23H24N2O3376.4564 / 03.4Yes
24232D structureCHEMBL3112601C23H24N2O3376.4564 / 03.4Yes
5359982D structureSCHEMBL4529392C27H24N2OS424.5623 / 05.5No
34592D structureCHEMBL1080571C26H32N4O2432.5684 / 13.9Yes
4592542D structureCHEMBL3909223C26H25FN6O2472.5247 / 03.9Yes
35132D structureCHEMBL3235265C25H26N4O2414.5094 / 13.9Yes
36032D structureSMR000010089C20H20N2O3336.3914 / 13.6Yes
5360132D structureSCHEMBL16464778C24H24N6O4460.4948 / 03.6Yes
5573882D structureSCHEMBL16655666C24H24N6O412.4975 / 14.0Yes
5360152D structureSCHEMBL4541596C22H24N4O3S424.5197 / 03.2Yes
5215512D structureCHEMBL3742398C23H20F2N2O6S490.4788 / 03.7Yes
5360182D structureSCHEMBL16463160C23H18F4N6O3502.4311 / 04.9No
39762D structureSCHEMBL1672410C22H26N4O3394.4756 / 02.8Yes
5360202D structureCHEMBL3985942C23H22FN7O2447.4747 / 02.5Yes
5360232D structureCHEMBL3920035C22H18F2N4O2408.4096 / 14.1Yes
5360252D structureCHEMBL3965933C19H20F3N5O391.3988 / 23.1Yes
40822D structureMLS001072368C23H26N4O374.4883 / 24.1Yes
42562D structureMLS001223988C22H28N2O4S416.5365 / 13.5Yes
5360372D structureSCHEMBL4532006C21H23N5O3393.4476 / 02.0Yes
4634182D structureCHEMBL3704932C23H22F4N6O474.46410 / 14.0Yes
44332D structureCHEMBL3235258C23H23N5O2401.475 / 13.0Yes
44932D structureCHEMBL1771432C19H17F3N4O374.3676 / 23.8Yes
5360542D structureSCHEMBL16463647C23H21ClN6O3464.917 / 04.3Yes
4634632D structureCHEMBL3659205C25H24N6O2440.5076 / 04.0Yes
5360552D structureSCHEMBL4540837C25H25FN2O3420.4845 / 03.8Yes
48972D structureSCHEMBL6925282C25H26FN5O431.5156 / 03.7Yes
5574172D structureSCHEMBL16666146C20H20FN3O4S417.4558 / 23.5Yes
51372D structureCID 44404999C121H209N43O34S2842.3340 / 40-11.4No
5197212D structureCHEMBL3902305C22H23N7O5465.4710 / 22.3Yes
5216152D structureCHEMBL3741065C23H19ClN2O4422.8654 / 04.4Yes
5360752D structureSCHEMBL4536986C22H24N4O3392.4595 / 02.4Yes
54562D structureBDBM50140022C94H151N25O252031.3928 / 23-3.4No
55242D structureCHEMBL2381082C27H26F3N3O3S529.5788 / 14.9No
56912D structureCHEMBL469146C23H23N7O413.4856 / 03.6Yes
4592732D structureCHEMBL3974582C23H21F2N7O3481.4649 / 03.2Yes
61132D structureSCHEMBL2027169C25H26N6O426.5245 / 12.5Yes
62912D structureCHEMBL2413512C21H22FN7O407.4537 / 02.9Yes
62932D structureCHEMBL3670630C21H22FN7O407.4537 / 02.9Yes
5360992D structureSCHEMBL16465942C23H21ClN6O3464.917 / 04.3Yes
63192D structureCHEMBL185136C19H20Cl2N2O3395.283 / 24.0Yes
5173512D structureSCHEMBL4536325C20H18ClF4NO3431.8127 / 05.4No
4636392D structureCHEMBL3622428C32H34N4O6S602.7068 / 34.4No
64442D structureCHEMBL2031484C28H27FN4O2S502.6086 / 15.5No
5479662D structureCHEMBL3901510C20H21N5O2S395.4816 / 03.2Yes
5574602D structureSCHEMBL16033642C20H21N5O2S395.4816 / 03.2Yes
65502D structureCHEMBL3649206C19H19FN8O2410.4135 / 10.6Yes
66232D structureCHEMBL524440C20H26N2O4S390.4985 / 03.2Yes
5574702D structureSCHEMBL16446669C21H26N6O2S426.5397 / 13.1Yes
66322D structureCHEMBL2413372C24H22FN3O3S451.5165 / 03.9Yes
5216412D structureCHEMBL3741474C22H19F2N3O6S491.4669 / 02.9Yes
66972D structureCHEMBL182269C24H25N3O3403.4824 / 23.3Yes
5574782D structureSCHEMBL16031595C21H24F3N3O2407.4377 / 14.5Yes
4636892D structureCHEMBL3704949C21H24F3N3O2407.4377 / 14.5Yes
5479692D structureCHEMBL3893886C21H24F3N3O2407.4377 / 14.5Yes
68622D structureSCHEMBL1671430C22H22N4OS390.5055 / 03.6Yes
68742D structureCHEMBL2031494C29H27N3O3465.5534 / 24.2Yes
5361142D structureSCHEMBL4536426C25H26N2O3402.4944 / 04.0Yes
70602D structureCHEMBL2381089C25H25F3N4OS486.5578 / 15.8No
5574832D structureSCHEMBL15658462C24H27N3O2389.4994 / 04.7Yes
5361562D structureCHEMBL3910747C21H20F3N7O443.43410 / 22.4Yes
4419882D structureCHEMBL3398471C21H20FN7O2421.4368 / 03.0Yes
4638072D structureCHEMBL3659198C23H21F2N3O2S441.4977 / 04.9Yes
5361662D structureSCHEMBL4534316C20H16F7NO2435.3429 / 05.3No
76402D structureCHEMBL2418838C31H37N3O6547.6527 / 23.7No
5361692D structureSCHEMBL16465387C24H23FN6O2446.4867 / 04.5Yes
76962D structure792173-99-0C17H13N5O2319.3245 / 22.0Yes
77392D structureCHEMBL1272096C17H15N5O3S2401.4598 / 12.4Yes
79052D structureMLS000096514C16H11NO4S2345.3877 / 04.0Yes
4592872D structureCHEMBL3896431C24H21ClN6O2460.9226 / 03.6Yes
81082D structureSCHEMBL1671269C26H23N5O421.5045 / 03.4Yes
5361802D structureSCHEMBL16464245C24H23FN6O3462.4858 / 04.1Yes
82612D structureCHEMBL3113758C21H23F3N2O4424.428 / 03.7Yes
5173602D structureSCHEMBL4534291C20H18ClF4NO4447.8118 / 05.0Yes

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