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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameSphingosine 1-phosphate receptor 2
SpeciesHomo sapiens (Human)
GeneS1PR2
SynonymEndothelial differentiation G-protein coupled receptor 5
Sphingosine 1-phosphate receptor Edg-5
S1P2 receptor
S1P2
S1P receptor Edg-5
[ Show all ]
DiseaseHypertension
Length353
Amino acid sequenceMGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV
UniProtO95136
Protein Data BankN/A
GPCR-HGmod modelO95136
3D structure modelThis predicted structure model is from GPCR-EXP O95136.
BioLiPN/A
Therapeutic Target DatabaseT47888
ChEMBLCHEMBL2955
IUPHAR276
DrugBankN/A

Known ligands

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Total entries: 640
Page:  / 7 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
5214392D structureCHEMBL3759551C29H30F2N2O6540.5648 / 35.3No
332D structureMLS000077136C12H11N3O6293.2358 / 1-0.1Yes
1482D structureCHEMBL325198C19H34NO3P355.4594 / 32.0Yes
13742D structureSMR000023524C17H26N2O2290.4073 / 04.2Yes
19542D structureCHEMBL2018573C28H25F2N5O3517.5377 / 14.9No
21702D structureSR-02000000242C19H15Cl2NO2360.2342 / 15.8No
4418312D structureCHEMBL3400190C24H32N2O3396.5313 / 25.1No
34972D structureCHEMBL377828C26H29N3O3431.5366 / 23.0Yes
35822D structureMLS000557830C24H23N3O369.4684 / 04.1Yes
37112D structureAC1NW0NQC14H13NO4S291.3215 / 02.5Yes
5215682D structureCHEMBL3759532C32H35FN2O6562.6387 / 35.8No
43862D structureCHEMBL117973C18H40NO3P349.4964 / 33.3Yes
46252D structureSMR000019512C15H8ClNO3S2349.8035 / 03.9Yes
49352D structurePseudoisocyanineC23H23N2+327.4511 / 05.6No
49632D structureSR-01000051804-2C19H19N3OS337.4414 / 03.6Yes
50882D structureCYM50199C14H12BrCl2NO2377.0593 / 05.2No
54832D structureCHEMBL224571C23H19ClF3NO3S481.9148 / 13.1Yes
57952D structureSR-01000759072-1C17H19N5OS341.4335 / 03.0Yes
60402D structureMLS000080860C16H16O5S2352.4195 / 11.4Yes
76802D structureCHEMBL196534C25H27N3O3417.5096 / 12.9Yes
89562D structureCHEMBL117007C19H34NO4P371.4585 / 40.6Yes
101002D structureCHEMBL226612C20H34FN2O5P432.4737 / 42.2Yes
106972D structureCHEMBL206940C21H21ClN2O4400.8596 / 15.0Yes
113952D structureMLS000529745C26H28N4O4S2524.6547 / 14.0No
5218062D structureCHEMBL3758974C30H33FN2O7552.5998 / 35.1No
122992D structureMLS000094258C15H10N4O2278.2714 / 00.5Yes
132112D structureCHEMBL1916399C22H15F3N4O5472.3811 / 13.2No
135072D structureCHEMBL224005C24H22F3NO3S461.4998 / 12.9Yes
139902D structureCHEMBL115131C19H33NO3S355.5374 / 22.7Yes
141542D structureN-(4-hydroxyphenyl)-2,4,5-trimethylbenzenesulfonamideC15H17NO3S291.3654 / 23.2Yes
144012D structureCHEMBL119562C15H34NO3P307.4154 / 31.6Yes
4646722D structureCHEMBL3618192C19H17ClF4N2O2416.8016 / 23.9Yes
158372D structure(1Z,3Z)-1,4-bis(butylsulfonyl)buta-1,3-dieneC12H22O4S2294.4244 / 02.1Yes
160682D structureCHEMBL218446C38H50N2O8S694.88410 / 311.1No
160712D structureCHEMBL218445C38H50N2O8S694.88410 / 311.1No
164872D structureSMR000094367C23H27N3O5S457.5457 / 13.4Yes
164932D structureCHEMBL118508C19H34NO5P387.4576 / 30.8Yes
179932D structureCHEMBL210301C20H21N3O4367.4057 / 13.6Yes
181732D structureBAS 09529732C16H17N3O3299.334 / 11.2Yes
195412D structureCHEMBL211689C21H19F3N2O4420.3889 / 14.8Yes
201042D structureCHEMBL241052C21H20N4O4392.4158 / 13.1Yes
4424612D structureCHEMBL3359519C24H24F3NO4447.4547 / 14.8Yes
210322D structureCHEMBL324358C15H33N2O5P352.4126 / 40.2Yes
213222D structureCHEMBL224599C23H19BrF3NO3S526.3688 / 13.2No
213652D structureCHEMBL332373C18H32NO4P357.4315 / 30.9Yes
226682D structureCHEMBL1975200C20H30N2O2330.4723 / 04.9Yes
5198042D structureCHEMBL3769933C21H24ClN5O3S461.9658 / 11.3Yes
4425642D structureCHEMBL3401388C29H34FN3O4507.6066 / 25.7No
232772D structureSCHEMBL14338632C19H34NO4P371.4585 / 41.0Yes
236422D structureSR-01000759095-1C25H25N3O3415.4933 / 13.7Yes
267602D structureCHEMBL208838C25H25F2N3O3453.498 / 22.0Yes
287132D structureSR-01000759097-1C26H25N3O4443.5034 / 13.3Yes
293442D structureCHEMBL224799C24H22F3NO3S461.4998 / 12.9Yes
305702D structureSMR000149318C27H24N6432.5314 / 14.5Yes
328912D structureCHEMBL195141C23H25N3O3391.4716 / 12.0Yes
336102D structureCHEMBL423691C19H38F3N2O7P494.48911 / 5N/ANo
336132D structureCHEMBL332472C19H38F3N2O7P494.48911 / 5N/ANo
337382D structureSR-01000759123-1C22H22N2O3362.4293 / 13.3Yes
359062D structureCHEMBL119239C18H32NO5P373.436 / 40.6Yes
360522D structureSR-01000759093-1C19H21N5OS367.4715 / 03.4Yes
4674622D structureCHEMBL3703200C36H44FN3O6633.7617 / 36.1No
373822D structureCHEMBL117569C21H46NO3P391.5774 / 35.0Yes
4431682D structureCHEMBL3401377C24H30ClFN2O3448.9634 / 25.8No
378122D structureCHEMBL239659C35H43NaO5S2630.8346 / 1N/ANo
384262D structureSR-01000759121-1C23H23NO4377.444 / 13.7Yes
5369692D structureSCHEMBL2192987C24H26N4O5S482.5559 / 13.1Yes
5369782D structureSCHEMBL1875982C24H26N4O5S482.5559 / 13.1Yes
386972D structureCHEMBL196149C23H25N3O3391.4716 / 11.6Yes
392082D structureCHEMBL187692C21H44NO2P373.5623 / 24.2Yes
418732D structureMLS000040640C18H25N5O2343.4316 / 14.2Yes
423992D structure3-(2-thienyl)-6-(trifluoromethyl)thieno[3,2-b]pyridineC12H6F3NS2285.3026 / 04.2Yes
430832D structureCHEMBL218447C37H48N2O7S664.8589 / 311.2No
438892D structureCHEMBL3213728C23H25ClN6O3468.9429 / 14.0Yes
439332D structureCHEMBL1975908C18H28N2O2304.4343 / 04.4Yes
4434122D structureCHEMBL3401376C25H33FN2O3428.5484 / 25.6No
443282D structureCHEMBL1086170C19H34NO4P371.4585 / 30.9Yes
445762D structureCYM50174C14H11Cl3N2O4377.6025 / 04.9Yes
4434432D structureCHEMBL3401379C30H34F2N2O4524.6096 / 26.8No
453022D structureCHEMBL1779916C18H17NO2S311.3993 / 14.6Yes
453632D structureSR-02000000239C19H16ClNO2325.7922 / 15.2No
474642D structureCHEMBL91283C38H66N2O7P2724.9019 / 7N/ANo
477932D structure3-MethyltoxoflavinC8H9N5O2207.1933 / 0-0.7Yes
490522D structureCHEMBL224800C24H22F3NO4S477.4989 / 12.5Yes
4436472D structureCHEMBL227530C18H31N2O4P370.435 / 40.5Yes
4436482D structureCHEMBL227851C18H31N2O4P370.435 / 40.5Yes
509202D structureMLS000083916C24H18N2O6430.4167 / 03.4Yes
515622D structureCHEMBL375488C25H24F3NO3S475.5268 / 13.3Yes
522172D structureSMR000128117C24H20N2O2368.4362 / 35.2No
4694632D structureCHEMBL3618193C19H17F5N2O2400.3497 / 23.3Yes
4696072D structureCHEMBL3618200C30H27F2N3O6S595.6189 / 34.1No
547252D structureMLS000549502C34H45N3O3543.7523 / 25.7No
4697172D structureCHEMBL3618195C19H17BrF4N2O445.2565 / 15.0Yes
553332D structure3-(2-thienyl)-6-(trifluoromethyl)thieno[3,2-b]pyridine-2-carboxylic acidC13H6F3NO2S2329.3118 / 14.0Yes
5231542D structureCHEMBL3758803C33H37FN2O6576.6657 / 36.4No
559662D structureCHEMBL115505C17H37N2O6P396.4657 / 41.3Yes
562442D structureSMR000180629C20H16N2OS332.4213 / 04.4Yes
563692D structureMLS000075167C13H16N4O3S308.3567 / 11.8Yes
578852D structureSR-01000759086-1C21H21NO4351.4024 / 04.1Yes
580492D structuremethyl 3-(2-pyridinyl)-6-(trifluoromethyl)thieno[3,2-b]pyridine-2-carboxylateC15H9F3N2O2S338.3048 / 03.6Yes
590722D structureCHEMBL1077288C20H33NO3335.4884 / 22.3Yes

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