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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

Name5-hydroxytryptamine receptor 2C
SpeciesRattus norvegicus (Rat)
GeneHtr2c
Synonym5-HT-1C
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
5-HT2C receptor
5-HT-2C
serotonin 1c receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length460
Amino acid sequenceMVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRHTNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV
UniProtP08909
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL324
IUPHAR8
DrugBankBE0004882

Known ligands

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Total entries: 972
Page:  / 10 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
872D structureEticloprideC17H25ClN2O3340.8484 / 23.1Yes
2592D structureCHEMBL109589C20H27NO297.4422 / 15.1No
5214582D structureCHEMBL3818128C19H23ClFN319.8482 / 1N/AN/A
7822D structure4-(4-Fluorobenzoyl)piperidineC12H14FNO207.2483 / 11.7Yes
8482D structure4-BenzylpiperidineC12H17N175.2751 / 12.5Yes
14722D structure4365 CTC14H20N2O232.3272 / 12.7Yes
21932D structureCHEMBL309992C22H26N4O4410.4746 / 13.1Yes
31532D structureAC1N0YGAC3H7NO4S153.1525 / 2-4.7Yes
35992D structure2-PhenylcyclopropanamineC9H11N133.1941 / 11.5Yes
36522D structureCHEMBL269396C21H22ClN323.8641 / 06.1No
5215592D structureCHEMBL3764080C20H24N4O3368.4376 / 11.3Yes
44672D structureCHEMBL211309C13H19NO3237.2994 / 11.3Yes
5215762D structureCHEMBL3765273C19H23ClN4O358.874 / 12.7Yes
50082D structureCHEMBL130585C21H23N3O3365.4334 / 03.8Yes
53142D structureCHEMBL2260621C17H17NO3S315.3875 / 13.5Yes
57712D structureparoxetineC19H20FNO3329.3715 / 13.5Yes
62672D structureCHEMBL76237C19H22N2O3S358.4564 / 03.5Yes
68702D structureCHEMBL13632C17H17BrClNO366.6832 / 14.7Yes
72462D structureCHEMBL426813C21H24ClN3O3401.8915 / 02.6Yes
80262D structureCHEMBL105152C19H25NO283.4152 / 14.4Yes
81582D structureCHEMBL3261700C28H29N3O2439.5593 / 25.6No
82162D structureBW-723C86C16H18N2OS286.3933 / 23.0Yes
103632D structureCHEMBL6426C11H11BrN2251.1271 / 22.2Yes
110552D structuretryptamineC10H12N2160.221 / 21.6Yes
111812D structureISOCLOZAPINEC18H19ClN4326.8283 / 13.1Yes
112212D structureCHEMBL61207C17H21BrN2O2365.2714 / 23.5Yes
117142D structurepropranololC16H21NO2259.3493 / 23.0Yes
124582D structureCHEMBL338696C22H25FN2O352.4533 / 13.6Yes
126082D structureCHEMBL148128C14H20FNO237.3183 / 12.3Yes
136772D structure8-OH-DpatC16H25NO247.3822 / 14.1Yes
140112D structureCHEMBL102268C20H27NO2313.4413 / 14.4Yes
141182D structureCHEMBL2260619C17H17NO2S299.3884 / 04.6Yes
145062D structureCHEMBL119323C13H16BrNO2298.183 / 12.0Yes
145082D structureCHEMBL331864C13H16BrNO2298.183 / 12.0Yes
158462D structureCHEMBL565707C25H31N3O4437.546 / 14.5Yes
160382D structureISOLOXAPINEC18H18ClN3O327.8123 / 03.1Yes
168872D structureGlemanserinC20H25NO295.4262 / 13.8Yes
183212D structureCHEMBL357870C16H14N4O278.3152 / 21.8Yes
201892D structureimipramineC19H24N2280.4152 / 04.8Yes
204052D structureCHEMBL338095C21H22ClFN2O372.8683 / 04.7Yes
5220662D structureCHEMBL3763812C18H21FN4O328.3915 / 11.9Yes
5220732D structureCHEMBL3765471C25H27ClF2N4O472.9656 / 2N/AN/A
216072D structureCHEMBL543964C16H16ClN3O301.7741 / 3N/AN/A
216682D structureCHEMBL310940C22H27N3O349.4784 / 03.7Yes
218542D structureCHEMBL126737C21H22ClFN2O372.8683 / 04.7Yes
223102D structureCHEMBL319998C15H18N2O242.3222 / 11.7Yes
226302D structureCHEMBL94067C24H25N327.4711 / 05.1No
229812D structureCHEMBL315790C19H21BrN2O373.2943 / 04.5Yes
230642D structureCHEMBL1744161C23H25N3O6439.4687 / 4N/AN/A
5533512D structure[125I]DOIC11H16INO2319.1593 / 12.5Yes
231612D structureCHEMBL134519C11H16INO2321.1583 / 12.5Yes
231662D structure1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amineC11H16INO2321.1583 / 12.5Yes
232482D structureDIHYDREXIDINEC17H17NO2267.3283 / 32.5Yes
233582D structuresulpirideC15H23N3O4S341.4266 / 20.6Yes
238502D structureCHEMBL6746C11H9BrN2249.1111 / 12.5Yes
250982D structureSCHEMBL8959504C11H12ClFN2226.6792 / 12.2Yes
251012D structureSCHEMBL8959894C11H12ClFN2226.6792 / 12.2Yes
251312D structureCHEMBL329280C28H31FN6O486.5954 / 13.4Yes
253142D structure6-Methoxy-4,9-dihydro-3H-beta-carbolineC12H12N2O200.2412 / 11.8Yes
260662D structureS-(-)-LisurideC20H26N4O338.4552 / 22.7Yes
265802D structureYohimbineC21H26N2O3354.454 / 22.9Yes
269842D structureCHEMBL108173C20H27NO2313.4413 / 14.4Yes
275942D structure2-phenethyl-1H-benzo[d]imidazoleC15H14N2222.2911 / 13.5Yes
281762D structureCHEMBL294902C17H19Br2NO2429.1523 / 14.8Yes
288642D structureCHEMBL314459C16H23NO3277.3644 / 32.4Yes
294182D structureCHEMBL1940420C18H22FN3O315.3925 / 03.7Yes
297572D structureCHEMBL111912C18H29NO275.4362 / 15.3No
308332D structureCHEMBL129230C22H23FN2O350.4373 / 03.7Yes
318792D structureCHEMBL556969C21H21NO303.4052 / 04.1Yes
322802D structureClorgilineC13H15Cl2NO272.1692 / 04.2Yes
326522D structureCHEMBL83658C19H22N2O294.3983 / 03.9Yes
330972D structureCHEMBL57939C17H19BrINO2476.1523 / 14.8Yes
331422D structureCHEMBL110151C18H23NO269.3882 / 14.0Yes
334442D structureCHEMBL3261701C24H24Cl2N2O2443.3683 / 15.9No
340722D structureCHEMBL318639C17H22N2O270.3762 / 12.6Yes
342612D structureCHEMBL2331807C14H16N2O2244.2943 / 11.3Yes
348042D structureCHEMBL1202030C21H24FNO325.4273 / 04.5Yes
377542D structureCHEMBL148385C18H18N4O306.3692 / 12.0Yes
378372D structureCHEMBL327527C27H30FN7O487.5835 / 13.2Yes
5226632D structureCHEMBL3754784C27H33ClN4O2S513.0976 / 04.9No
383982D structure4-EthoxyamphetamineC11H17NO179.2632 / 12.1Yes
386232D structure3-[2-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]-1H-benzimidazol-2-oneC20H21F3N4O390.416 / 13.3Yes
5584572D structureCHEMBL70609C19H22N4O3S386.476 / 12.0Yes
390562D structureCHEMBL126823C21H24N2O320.4362 / 03.9Yes
395452D structureCHEMBL313856C11H12ClFN2226.6792 / 12.2Yes
400612D structureCHEMBL85507C20H25FN2O328.4314 / 14.6Yes
403072D structureAripiprazoleC23H27Cl2N3O2448.3884 / 14.6Yes
405902D structure1-(2,6-dimethoxy-4-methylphenyl)propan-2-amineC12H19NO2209.2893 / 12.0Yes
409642D structure16502-01-5C11H12N2172.2311 / 21.5Yes
5227872D structureCHEMBL3764284C19H23ClN4O358.874 / 12.7Yes
427352D structureCHEMBL79496C19H20N2O2308.3813 / 03.3Yes
431542D structure64022-27-1C8H11ClN4198.6544 / 10.5Yes
433452D structureCHEMBL318249C28H32FN7O501.615 / 13.2No
435542D structurefluvoxamineC15H21F3N2O2318.347 / 12.6Yes
443092D structureCHEMBL1202030C23H26FNO5415.4617 / 2N/AN/A
5586482D structureCHEMBL2260626C16H14N2O250.3012 / 23.9Yes
445362D structureCHEMBL276031C19H26N2O298.432 / 13.9Yes
449692D structureCHEMBL98299C27H30FN7O487.5835 / 13.2Yes
451432D structureCHEMBL445106C12H14BrNO2284.1533 / 11.9Yes
5228452D structureCHEMBL3765797C18H22N4O3342.3995 / 10.9Yes

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