Home Research Services Publications People Teaching Job Opening Facilities News Forum Lab Only
Online Services

I-TASSER QUARK LOMETS COACH COFACTOR MetaGO MUSTER SEGMER FG-MD ModRefiner REMO DEMO SPRING COTH BSpred SVMSEQ ANGLOR BSP-SLIM SAXSTER ThreaDom ThreaDomEx EvoDesign GPCR-I-TASSER BindProf BindProfX ResQ IonCom STRUM DAMpred

TM-score TM-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR NeBcon WDL-RF ATPbind DockRMSD

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

You can:

GPCR

NameMuscarinic acetylcholine receptor M1
SpeciesMus musculus (Mouse)
GeneChrm1
Synonymcholinergic receptor, muscarinic 1
cholinergic receptor, muscarinic 1, CNS
cholinergic receptor
M1 muscarinic acetylcholine receptor
M1 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length460
Amino acid sequenceMNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
UniProtP12657
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3733
IUPHAR13
DrugBankN/A

Known ligands

You can:

Total entries: 77
Page:  / 1 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
66112D structurecarbacholC6H15ClN2O2182.6483 / 1N/AN/A
127232D structureN,N'-Bis[2-[[5-(dimethylaminomethyl)-2-furanyl]methylthio]ethyl]-1-nitroethene-1,2-diamineC22H35N5O4S2497.67310 / 22.7Yes
130612D structure158142-45-1C6H10N2O2142.1583 / 1-0.9Yes
214072D structureCHEMBL68240C12H15NO2205.2573 / 11.2Yes
227502D structureBRN 5352858C18H28N2O2S2368.5546 / 02.5Yes
257242D structure114724-56-0C9H13N3O179.2234 / 00.8Yes
258662D structureBRN 5360513C24H32N2O2S2444.6526 / 03.8Yes
370302D structureCHEMBL538467C6H11ClN2O2178.6163 / 2N/AN/A
373602D structureOxotremorine MC11H19N2O+195.2861 / 0-0.1Yes
428232D structureBRN 5358078C24H40N2O2S2452.7166 / 05.0Yes
451462D structureCHEMBL445106C12H14BrNO2284.1533 / 11.9Yes
522572D structureCHEMBL1183133C8H12N4OS212.2715 / 1-0.3Yes
567262D structureBRN 5356180C21H34N2O2S2410.6356 / 03.5Yes
597022D structureUNII-KU4UTQ0410C10H13F3N4O3294.2349 / 2N/AN/A
674672D structureCHEMBL538224C6H12ClN3O2193.6313 / 3N/AN/A
780502D structureCHEMBL542561C8H12ClN3O2217.6533 / 3N/AN/A
789312D structureCHEMBL542561C8H11N3O2181.1953 / 2-1.4Yes
848812D structureCHEMBL542559C9H13ClN2O2216.6653 / 2N/AN/A
895242D structureBRN 5838245C19H26N6O5S450.51410 / 24.0Yes
1058912D structureBRN 5836339C17H23N5O5S409.4619 / 23.8Yes
1070372D structureBRN 5834442C16H20N4O5S380.4198 / 13.2Yes
1077092D structureBRN 5840026C22H25N5O5S471.5329 / 25.3No
1097952D structureBRN 5836042C16H21N5O5S395.4349 / 23.1Yes
1164332D structurearecolineC8H13NO2155.1973 / 00.3Yes
1292312D structureBRN 5841166C22H26N6O5S486.54710 / 24.2Yes
1360862D structureAbt-418C9H14N2O166.2243 / 01.2Yes
1386472D structureUNII-9F064NJ81DC8H12N4O180.2114 / 10.1Yes
1486812D structureBDBM50005504C22H35N5O4S2497.67310 / 11.9Yes
1560032D structureXANOMELINEC14H23N3OS281.4185 / 03.3Yes
1560812D structureBRN 5837330C19H27N5O5S437.5159 / 24.7Yes
1618892D structure5-propargyloxycarbonyl-1,4,5,6-tetrahydropyrimidine hydrochlorideC8H11ClN2O2202.6383 / 2N/AN/A
1668912D structureZINC1535055C8H10N2O2166.183 / 1-0.8Yes
1824702D structure142744-14-7C16H19FN4O5S398.4099 / 13.3Yes
1862562D structureBRN 5838753C20H30N6O5S466.55710 / 23.8Yes
1934802D structureBRN 5365697C22H34N6O2S2478.6748 / 21.8Yes
2089752D structureCID 44457650C10H13F3N4O4310.23310 / 2N/AN/A
2125042D structureCHEMBL543030C11H15ClN2O2242.7033 / 2N/AN/A
2150652D structureBRN 5841483C23H24N6O5S496.54210 / 25.0Yes
2174662D structureBRN 5359326C25H42N2O2S2466.7436 / 05.5No
2209742D structure158930-48-4C7H12N2O2156.1853 / 1-1.0Yes
2217392D structureBRN 5829247C16H20FN3O3S353.4127 / 13.5Yes
2269392D structureBRN 5841153C22H26N6O5S486.54710 / 24.2Yes
2286622D structureBRN 5357514C23H38N2O2S2438.6896 / 04.4Yes
2303622D structureCHEMBL66241C14H19NO2233.3113 / 02.2Yes
2311152D structureCHEMBL1178328C11H14N4O218.264 / 11.0Yes
2381362D structureCHEMBL542064C9H12N2O2180.2073 / 1-0.3Yes
2516242D structureBRN 5369860C26H36N6O6S2592.7312 / 24.9No
2558282D structureCHEMBL543030C11H14N2O2206.2453 / 10.5Yes
2579312D structuremethyl 6-amino-2,3,4,5-tetrahydropyridine-3-carboxylate hydrochlorideC7H13ClN2O2192.6433 / 2N/AN/A
2605452D structurephysostigmineC15H21N3O2275.3524 / 10.7Yes
2610252D structureBRN 5837136C16H22N6O5S410.44910 / 33.0Yes
2748162D structurepilocarpineC11H16N2O2208.2613 / 01.1Yes
2758832D structureCHEMBL542064C9H13ClN2O2216.6653 / 2N/AN/A
2808822D structureCID 44457579C10H13F3N4O3S326.29410 / 2N/AN/A
2812822D structureBRN 5354948C20H32N2O2S2396.6086 / 03.2Yes
2979312D structureCHEMBL1800285C22H20N4O3388.4276 / 1-0.6Yes
3037552D structureOxotremorineC12H18N2O206.2892 / 00.4Yes
3064442D structureBRN 5363156C30H36N2O2S2520.756 / 05.4No
3103922D structureSCHEMBL8305377C7H10N4O166.1844 / 1-0.4Yes
3144342D structureCHEMBL541398C7H13ClN2O2192.6433 / 2N/AN/A
3396082D structureCHEMBL557795C9H13ClN2O2216.6653 / 2N/AN/A
3441292D structureZINC3786169C7H12N2O2156.1853 / 1-0.5Yes
3596392D structureSCHEMBL8307259C9H11F3N4O3280.2079 / 2N/AN/A
3609442D structureCarbamylcholineC6H15N2O2+147.1982 / 1-0.4Yes
3643082D structureCHEMBL542559C9H12N2O2180.2073 / 1-0.3Yes
3653572D structureOxotremorine MC11H19IN2O322.192 / 0N/AN/A
3940172D structureA-85380C9H12N2O164.2083 / 10.6Yes
3943072D structureCHEMBL557795C9H12N2O2180.2073 / 1-0.9Yes
4065042D structureBRN 5841077C23H34N6O6S522.62111 / 23.8No
4102122D structureCID 44457666C13H15F3N4O3332.2839 / 2N/AN/A
4129972D structureTacrineC13H14N2198.2692 / 12.7Yes
4178802D structureCHEMBL321808C14H19N5O3S337.3988 / 11.7Yes
4213362D structureBRN 5840630C22H24FN5O5S489.52210 / 25.4No
4314302D structureCHEMBL538224C6H11N3O2157.1733 / 2-1.5Yes
4354962D structureBRN 5356615C22H36N2O2S2424.6626 / 03.9Yes
4401822D structureBRN 5840829C23H27N5O5S485.5599 / 25.3No
4405552D structureBRN 5353847C19H30N2O2S2382.5816 / 02.8Yes

yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218