Home Research Services Publications People Teaching Job Opening Facilities News Forum Lab Only
Online Services

I-TASSER QUARK LOMETS COACH COFACTOR MetaGO MUSTER SEGMER FG-MD ModRefiner REMO DEMO SPRING COTH BSpred SVMSEQ ANGLOR BSP-SLIM SAXSTER ThreaDom ThreaDomEx EvoDesign GPCR-I-TASSER BindProf BindProfX ResQ IonCom STRUM DAMpred

TM-score TM-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR NeBcon WDL-RF ATPbind DockRMSD

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

You can:

GPCR

NameEndothelin receptor type B
SpeciesHomo sapiens (Human)
GeneEDNRB
SynonymETB receptor
ET-B
Endothelin receptor non-selective type
HSCR2
endothelin B receptor
[ Show all ]
DiseaseArrhythmia
Cancer
Cardiovascular disorder
Hypertension
Solid tumours
[ Show all ]
Length442
Amino acid sequenceMQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNASLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
UniProtP24530
Protein Data Bank5xpr, 6igl, 5x93, 6igk
GPCR-HGmod modelP24530
3D structure modelThis structure is from PDB ID 5xpr.
BioLiPBL0388896, BL0388813, BL0433639, BL0433638, BL0388814
Therapeutic Target DatabaseT92828
ChEMBLCHEMBL1785
IUPHAR220
DrugBankBE0000043

Known ligands

You can:

Total entries: 1340
Page:  / 14 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
2672D structureCHEMBL329744C30H36N4O5532.6418 / 22.5No
4402D structureCHEMBL31662C27H22O5426.4685 / 24.5Yes
10752D structureCHEMBL321831C28H42N2O6502.6527 / 12.1No
11612D structureCHEMBL10781C29H28O10536.53310 / 13.9No
17022D structureCHEMBL103001C24H21NO5403.4346 / 13.8Yes
17452D structureCHEMBL94918C24H25N3O6S483.5397 / 13.3Yes
23882D structureCHEMBL2165330C24H22BrClN6O6S637.8912 / 24.1No
29322D structureCHEMBL94438C30H26F2N4O4544.5599 / 22.1No
32912D structureCHEMBL47868C29H29NO10551.54811 / 21.7No
32932D structureCHEMBL298664C29H29NO10551.54811 / 21.7No
33642D structureCHEMBL367444C29H33N5O7S3659.79113 / 24.9No
33742D structureCHEMBL9139C27H34N2O6482.5777 / 11.7Yes
41142D structureCHEMBL326191C30H40N2O5508.6596 / 12.6No
41812D structureCHEMBL55853C25H19NO6429.4286 / 14.3Yes
46702D structureCHEMBL10860C28H21NO6467.4777 / 14.3Yes
52912D structureCHEMBL316523C37H41NO12691.7312 / 16.4No
58312D structureCHEMBL70924C30H34N6O6S606.69810 / 34.9No
62242D structureCHEMBL306218C21H20N2O4364.4016 / 13.4Yes
62812D structureCHEMBL102825C23H19NO5389.4076 / 13.4Yes
65132D structureCHEMBL147238C22H19N3O4S421.4716 / 13.2Yes
65792D structureCHEMBL9141C24H28N2O6440.4967 / 20.6Yes
71052D structureCHEMBL92612C22H20N4O4404.4267 / 2-0.4Yes
75562D structureCHEMBL56349C26H21NO6443.4556 / 13.4Yes
84392D structureCHEMBL274370C24H19NO6417.4176 / 14.9Yes
88602D structureCHEMBL129220C30H40N2O7540.6578 / 12.4No
89092D structureCHEMBL112770C29H46N2O5502.6966 / 14.1No
103682D structureCHEMBL296927C20H18ClN3O8S2527.94711 / 23.1No
104192D structureCHEMBL281977C32H29N5O5S595.6748 / 15.1No
107542D structureCHEMBL109474C29H44N2O6516.6797 / 12.3No
114242D structureCHEMBL123997C32H36N2O6544.6487 / 23.4No
116252D structureCHEMBL102969C27H27NO5445.5156 / 15.1No
122882D structureCHEMBL275701C28H26O9506.5079 / 14.0No
123732D structureCHEMBL368945C31H29N5O9S3711.77915 / 24.9No
124162D structureCHEMBL416518C24H17NO6415.4016 / 14.7Yes
124192D structureCHEMBL2163720C25H27BrN8O6S647.50514 / 23.2No
127152D structureCHEMBL450628C27H31N5O4489.5768 / 20.4Yes
135402D structureCHEMBL172030C31H32N6O7S3696.81214 / 25.2No
137172D structureCHEMBL1271640C32H31NO8557.5999 / 26.3No
149472D structureCHEMBL330135C34H34ClFN4O4617.1188 / 24.5No
156192D structureCHEMBL103501C34H29NO7563.6067 / 16.3No
156562D structureSCHEMBL5351769C26H24N6O5500.51510 / 3-0.5No
157692D structureCHEMBL332109C38H37F3N2O8706.71512 / 3N/ANo
158612D structureCHEMBL43788C17H16ClN3O6S2457.99 / 23.0Yes
163662D structureCHEMBL432815C19H21BrN2O3S2469.4126 / 15.9No
166612D structureCHEMBL274489C27H30N4O5S522.628 / 14.7No
171042D structureCHEMBL96114C32H32N4O4536.6327 / 22.7No
171522D structureCHEMBL2440659C15H11FN4O2S330.3377 / 12.4Yes
176592D structureCHEMBL1627022C27H27BrN5NaO5S636.49710 / 1N/ANo
185812D structureCHEMBL359273C21H18N4O3S406.467 / 13.6Yes
191742D structureCHEMBL61211C27H24O7460.4827 / 14.9Yes
197652D structureCHEMBL157742C27H21NO6455.4666 / 14.9Yes
201542D structureCHEMBL65939C31H31NO7529.5898 / 14.5No
203872D structureCHEMBL2163722C25H25BrN8O7S661.48815 / 11.8No
203912D structureCHEMBL110904C28H42N2O5486.6536 / 13.3Yes
204412D structureCHEMBL172297C31H36N4O7S3672.8312 / 26.1No
208932D structureCHEMBL342615C30H42N6O8S646.768 / 61.6No
209052D structureCHEMBL286808C19H14O5322.3165 / 22.1Yes
210722D structureCHEMBL267096C26H24O6432.4726 / 14.2Yes
215362D structureCHEMBL175057C28H25N9O5S599.62613 / 23.2No
217662D structureCHEMBL269409C29H22O6466.4896 / 15.3No
5221552D structureCHEMBL3775436C15H26ClNO3303.8274 / 3N/AN/A
5222022D structureCHEMBL3775769C15H26ClNO3303.8274 / 3N/AN/A
222952D structureCHEMBL102314C27H27NO5445.5156 / 15.0Yes
223282D structure184040-74-2C9H7ClN2O5S2322.7348 / 21.8Yes
227222D structureCHEMBL47417C18H18BrN3O4S2484.3837 / 24.3Yes
234572D structureCHEMBL45875C18H18N2O4S2390.4727 / 13.6Yes
243172D structureCHEMBL170335C23H32O5388.5045 / 23.4Yes
244572D structureCHEMBL2165332C24H23BrN6O4S571.4510 / 24.0No
248232D structureCHEMBL10733C25H19ClO6450.8716 / 14.7Yes
252102D structureCHEMBL156269C27H21NO6455.4666 / 14.9Yes
254322D structureCHEMBL41087C24H20O6404.4186 / 24.1Yes
254522D structureCHEMBL123316C34H37F3N2O8658.67112 / 3N/ANo
257662D structureCHEMBL122832C29H30N2O8534.5659 / 21.2No
259742D structureCHEMBL79054C11H10Cl2N2O3S321.1725 / 12.9Yes
261752D structureCHEMBL314755C30H27FN4O4526.5688 / 22.0No
269572D structureCHEMBL276615C23H17NO5387.3915 / 14.9Yes
271772D structureCHEMBL2203713C18H22N4S326.4624 / 22.9Yes
276402D structureCHEMBL419367C28H34F4N2O7S618.64113 / 12.5No
277132D structureCHEMBL265116C53H63N7O10958.12610 / 96.4No
287692D structureCHEMBL114074C29H41N3O6527.6628 / 12.5No
290362D structurePD-159020C32H25NO8551.5518 / 16.1No
293072D structureCHEMBL22367C26H23N3O7S521.5447 / 22.7No
295552D structureCHEMBL264253C51H54N8O10939.03911 / 110.8No
298902D structureCHEMBL10911C25H20O5S432.496 / 14.6Yes
302352D structureCHEMBL104848C20H17N3O4S395.4337 / 13.7Yes
302592D structureCHEMBL421190C49H65N7O8880.18 / 85.8No
303192D structureCHEMBL121647C33H35F3N2O8644.64412 / 3N/ANo
311062D structureCHEMBL432109C17H15ClN2O5S2426.8868 / 13.5Yes
313052D structureCHEMBL2165337C17H16Br2N6O4S560.22110 / 22.8No
313122D structureCHEMBL322799C28H39N3O7529.6348 / 10.2No
317662D structureCHEMBL280379C26H23N3O7S521.5447 / 22.7No
317902D structureCHEMBL9334C28H36N2O6496.6047 / 12.0Yes
320222D structureCHEMBL173189C18H19BrN2O3S2455.3856 / 15.3No
320272D structureCHEMBL330895C33H38N2O6558.6757 / 23.3No
321752D structureCHEMBL288967C18H15BrF3N3O7S2586.35113 / 3N/ANo
325372D structureCHEMBL2163705C30H26F3N7O6S669.63616 / 14.4No
329502D structureCHEMBL155708C29H26N2O8S562.5939 / 14.0No
332722D structureCHEMBL45760C19H20BrN3O4S2498.417 / 25.0Yes
335312D structureCHEMBL174094C29H28N4O5S544.6269 / 15.2No
335502D structureCHEMBL133257C33H44N6O7636.757 / 62.7No

yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218