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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameProteinase-activated receptor 1
SpeciesHomo sapiens (Human)
GeneF2R
SynonymPAR-1
coagulation factor II (thrombin) receptor
Coagulation factor II receptor
PAR1
protease-activated receptor 1
[ Show all ]
DiseaseRestenosis
Acute coronary syndrome
Atherosclerosis
Cancer
Myocardial infarction
[ Show all ]
Length425
Amino acid sequenceMGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
UniProtP25116
Protein Data Bank3vw7
GPCR-HGmod modelP25116
3D structure modelThis structure is from PDB ID 3vw7.
BioLiPBL0217099
Therapeutic Target DatabaseT36483
ChEMBLCHEMBL3974
IUPHAR347
DrugBankBE0000928

Known ligands

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Total entries: 1105
Page:  / 12 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
5359272D structureCHEMBL3930467C25H24F2N2O3438.4757 / 14.5Yes
5852D structureCHEMBL3143254C41H52FN9O6785.9229 / 72.7No
5862D structureCHEMBL231713C25H19ClFNO2419.884 / 05.5No
19032D structureCHEMBL198473C26H28FNO2405.5134 / 06.2No
34952D structureCHEMBL33377C27H35N11O4577.658 / 80.1No
40752D structureCHEMBL307065C25H33N3O4439.5565 / 3-0.8Yes
40762D structureCHEMBL3143278C49H65F2N13O81002.1413 / 101.2No
54132D structureCHEMBL597091C17H23ClN2OS338.8943 / 04.1Yes
4592712D structureCHEMBL3704460C20H25F5N6O3S524.51112 / 15.9No
60332D structureCHEMBL338639C33H58N12O5702.9068 / 10-0.6No
61672D structureCHEMBL596706C19H25ClN2OS364.9323 / 04.9Yes
68262D structureCHEMBL2012502C26H31NO3405.5384 / 15.4No
71162D structureCHEMBL287469C24H39N13O4573.6639 / 9-0.6No
74342D structureCHEMBL232333C25H18ClF2NO2437.8715 / 05.6No
76372D structureCHEMBL91987C25H31Cl2N3O3492.4413 / 34.7Yes
77042D structure2-bromo-N-[3-(pentanoylamino)phenyl]benzamideC18H19BrN2O2375.2662 / 24.0Yes
80122D structureCHEMBL132128C29H49N9O5603.7697 / 80.4No
5361772D structureCHEMBL3954641C27H26ClF2N3O3513.978 / 05.8No
85442D structureCHEMBL2048428C17H17N3O4327.344 / 22.6Yes
89132D structureCHEMBL410157C29H31F3N2O4528.5728 / 05.5No
90152D structureCHEMBL411798C61H64FN15O111202.2817 / 115.2No
90572D structureCHEMBL340389C31H53N9O6647.8228 / 8-0.2No
4592992D structureSCHEMBL1204282C22H27ClN6O3458.9477 / 13.2Yes
96882D structureCHEMBL2012501C26H31NO3405.5384 / 15.4No
108422D structureCHEMBL371751C26H28ClNO2421.9653 / 06.7No
113092D structureCHEMBL337852C30H52N10O5632.8118 / 9-1.0No
117602D structureCHEMBL71411C39H41Cl2F2N7O3S796.768 / 55.8No
5363312D structureCHEMBL3945945C25H22F2N6O2476.4889 / 04.2Yes
129902D structureCHEMBL590626C18H25ClN2OS352.9213 / 04.6Yes
132952D structureCHEMBL147872C39H51F2N11O5791.9069 / 81.9No
132962D structureCHEMBL3143306C39H51F2N11O5791.9069 / 81.9No
143852D structureCHEMBL3143277C36H48FN11O5S765.919 / 91.7No
143862D structureCHEMBL144504C36H48FN11O5S765.919 / 91.7No
151662D structureCHEMBL132254C31H53N9O5631.8237 / 70.8No
152242D structureCHEMBL98231C30H42N4O2490.6924 / 26.3No
156152D structureCHEMBL415138C49H77N15O151116.2416 / 15-4.8No
157502D structureCHEMBL63426C23H25N5371.4884 / 24.9Yes
159022D structureCHEMBL596686C19H27ClN2OS366.9483 / 04.9Yes
161122D structureCHEMBL500551C30H35FN2O4506.6186 / 05.5No
167052D structureCHEMBL3143253C43H54FN9O7827.95910 / 72.5No
175212D structureCHEMBL42224C38H53FN10O5748.90510 / 82.3No
178412D structureCHEMBL3109580C27H31FN2O2434.5555 / 14.6Yes
185752D structureCHEMBL2047280C14H14BrN3O3352.1884 / 22.7Yes
5364812D structureCHEMBL3952681C27H28ClF2N3O3515.9868 / 24.3No
204912D structureCHEMBL204955C24H28N2O2376.54 / 15.1No
206302D structureCHEMBL7610C44H51Cl2N9O4840.8516 / 65.5No
206902D structureCHEMBL232120C18H21NO2S315.4314 / 03.9Yes
207202D structureCHEMBL278216C34H45N11O5S719.8669 / 82.9No
207472D structureCHEMBL323054C26H30FN3O3451.5427 / 05.5No
207742D structureCHEMBL382830C32H34N2O4510.6345 / 16.7No
215202D structureCHEMBL1271353C29H35N3O5505.6157 / 14.1No
215322D structureCHEMBL504651C45H53Cl2N9O4854.8786 / 65.9No
219912D structureCHEMBL308052C40H42Cl2F2N8O3791.7268 / 55.0No
219952D structureCHEMBL269006C25H19F2NO2403.4295 / 05.0Yes
221542D structureCHEMBL337875C30H51N9O5617.7967 / 8-0.8No
221552D structureCHEMBL244484C28H31FN2O4478.5646 / 04.8Yes
5365562D structureCHEMBL3909563C25H23ClF2N2O2456.9186 / 05.3No
228162D structureCHEMBL326456C26H30ClN3O3467.9946 / 06.0No
236692D structureCHEMBL198175C27H31NO3417.5494 / 06.1No
244122D structureCHEMBL275946C43H50FN9O3759.9316 / 64.4No
245172D structureCHEMBL599363C17H24N2OS304.4523 / 03.5Yes
245502D structureCHEMBL199101C26H28FNO2405.5134 / 06.2No
246002D structureCHEMBL33940C26H39N11O4569.6718 / 80.9No
246372D structureCHEMBL197791C22H29NO2339.4793 / 05.3No
246382D structureCHEMBL195909C22H29NO2339.4793 / 05.3No
253332D structureCHEMBL1081087C18H14F2N2O312.325 / 03.5Yes
4594532D structureCHEMBL342337C40H53FN12O6816.9410 / 91.5No
270342D structureCHEMBL3143263C40H53FN12O6816.9410 / 91.5No
272732D structureCHEMBL2012497C25H27Cl2NO2444.3963 / 07.0No
282742D structureCHEMBL233163C25H19F2NO2403.4295 / 05.0Yes
284182D structureCHEMBL596676C16H22ClN3OS339.8824 / 03.5Yes
5367352D structureCHEMBL3964337C25H24ClF2N5O2499.9478 / 15.1No
301892D structure2-methyl-N-[2-methyl-3-(propionylamino)phenyl]benzamideC18H20N2O2296.372 / 22.9Yes
302682D structureCHEMBL436130C27H31NO2401.553 / 06.5No
312982D structureCHEMBL3091980C24H29FN2O2S428.5665 / 05.2No
313222D structureCHEMBL198375C26H28BrNO2466.4193 / 06.8No
5368202D structureCHEMBL3924976C29H33F2N3O2493.5997 / 16.1No
320832D structureCHEMBL267059C42H46Cl2F2N10O3847.7948 / 64.7No
329132D structureCHEMBL287156C21H31N11O4501.5528 / 8-1.5No
332442D structureCHEMBL3091993C24H27FN2O2394.494 / 15.5No
333192D structureCHEMBL382733C26H37NO2395.5873 / 07.3No
333222D structureCHEMBL3109584C30H35FN2O3490.6195 / 15.4No
335742D structureCHEMBL268328C45H52F3N9O5855.96410 / 65.5No
336472D structureCHEMBL383606C29H33NO4459.5865 / 06.3No
345682D structureCHEMBL3143281C48H65F2N15O71002.1412 / 110.7No
351572D structureCHEMBL219282C27H31NO3417.5494 / 14.8Yes
358772D structureCHEMBL2049112C18H19BrN2O2375.2662 / 23.8Yes
363602D structureCHEMBL108604C29H33N3O439.6034 / 06.8No
364342D structureCHEMBL244299C29H31FN2O3474.5765 / 04.4Yes
372852D structureCHEMBL374503C26H27Cl2NO3472.4064 / 15.7No
375402D structureCHEMBL598962C19H26N2O3S362.4885 / 03.2Yes
378982D structureCHEMBL3143312C38H52FN9O8781.88711 / 8-0.1No
379432D structureCHEMBL604175C19H26Cl2N2OS401.393 / 05.6No
391302D structureCHEMBL130226C30H51N9O6633.7958 / 9-0.5No
391312D structureCHEMBL336277C30H51N9O6633.7958 / 9-0.5No
391322D structureCHEMBL134820C30H51N9O6633.7958 / 9-0.5No
391342D structureH-SER-PHE-LEU-LEU-ARG-NH2C30H51N9O6633.7958 / 9-0.5No
391352D structureCHEMBL133618C30H51N9O6633.7958 / 9-0.5No
391362D structureCHEMBL335036C30H51N9O6633.7958 / 9-0.5No
396852D structureCHEMBL111258C27H33N3O3447.5796 / 05.8No

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