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GPCR

NameEndothelin-1 receptor
SpeciesRattus norvegicus (Rat)
GeneEdnra
Synonymendothelin A receptor
Endothelin receptor type A {ECO:0000312|RGD:2535}
ENDOR
endothelin-1 receptor
ET-A
[ Show all ]
DiseaseN/A for non-human GPCRs
Length426
Amino acid sequenceMGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCMLNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSSHKDSMN
UniProtP26684
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4566
IUPHAR219
DrugBankN/A

Known ligands

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Total entries: 1056
Page:  / 11 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
4812D structureBDBM50279801C106H153N25O32S52449.8340 / 32-5.0No
8422D structureCHEMBL96847C26H29N3O6S511.5937 / 14.1No
10742D structureCHEMBL321831C28H42N2O6502.6527 / 12.1No
15062D structureCHEMBL326861C27H36N2O7S532.6529 / 11.4No
17462D structureCHEMBL94918C24H25N3O6S483.5397 / 13.3Yes
23622D structureCHEMBL109736C26H32N2O5452.5516 / 11.0Yes
29102D structureCHEMBL287819C33H30N6OS558.7047 / 07.3No
33612D structureCHEMBL367444C29H33N5O7S3659.79113 / 24.9No
33752D structureCHEMBL9139C27H34N2O6482.5777 / 11.7Yes
41122D structureCHEMBL326191C30H40N2O5508.6596 / 12.6No
41822D structureCHEMBL55853C25H19NO6429.4286 / 14.3Yes
45712D structureCHEMBL9082C25H29NO6439.5087 / 11.5Yes
50892D structureCHEMBL328786C20H15NO5S381.4026 / 14.5Yes
54682D structureCHEMBL348685C20H22N2O3S2402.5276 / 14.6Yes
54772D structureCHEMBL177378C31H32O9548.5889 / 15.7No
54812D structureCHEMBL92607C22H18O3330.3833 / 15.0Yes
59622D structureCHEMBL315280C27H21ClN2O7520.9228 / 25.3No
65762D structureCHEMBL9141C24H28N2O6440.4967 / 20.6Yes
68642D structureCHEMBL368255C30H41N5O5551.6886 / 45.0No
69262D structureCHEMBL174235C24H18N2O5414.4177 / 14.6Yes
75552D structureCHEMBL56349C26H21NO6443.4556 / 13.4Yes
78932D structureCHEMBL38270C28H21K2NO7561.6738 / 0N/ANo
86542D structureCHEMBL151525C23H26N2O5S442.537 / 15.6No
88612D structureCHEMBL129220C30H40N2O7540.6578 / 12.4No
89082D structureCHEMBL112770C29H46N2O5502.6966 / 14.1No
93032D structureCHEMBL176992C30H41N5O4S567.7496 / 45.6No
96962D structureCHEMBL93411C20H16ClNO4S401.8615 / 15.2No
107552D structureCHEMBL109474C29H44N2O6516.6797 / 12.3No
111982D structureCHEMBL266337C25H30N2O6454.5237 / 21.0Yes
113762D structureCHEMBL266143C26H26N2O5446.5037 / 11.3Yes
118402D structureCHEMBL146845C24H31N3O3S441.596 / 26.1No
119552D structureCHEMBL368270C29H22O6466.4896 / 16.0No
121492D structureCHEMBL27344C18H21N3O3S359.4446 / 13.8Yes
122642D structureCHEMBL293702C22H22O6382.4126 / 14.5Yes
123592D structureCHEMBL94141C23H21NO4S407.4846 / 14.5Yes
123612D structureCHEMBL94071C23H21NO4S407.4846 / 14.5Yes
123642D structureCHEMBL90320C23H21NO4S407.4846 / 14.5Yes
123772D structureCHEMBL65292C27H32O7468.5467 / 16.3No
128762D structureCHEMBL286682C14H19N3O3S309.3846 / 22.6Yes
135342D structureCHEMBL176093C29H39N5O5537.6616 / 43.8No
135382D structureCHEMBL172030C31H32N6O7S3696.81214 / 25.2No
136112D structureCHEMBL172543C33H40N6O5600.727 / 34.3No
138582D structure4-amino-n-(1,3,4-thiadiazol-2-yl)benzenesulfonamideC8H8N4O2S2256.2987 / 20.5Yes
143012D structureCHEMBL299328C27H21N2O8S-533.53111 / 05.2No
149942D structureCHEMBL172506C34H42N6O5614.7477 / 34.6No
150032D structureCHEMBL173054C25H23NO4401.4625 / 15.5No
165482D structureCHEMBL30075C15H15N3O3S317.3636 / 22.3Yes
166422D structureCID 44270771C108H161N25O32S52481.9240 / 36-5.5No
170252D structureCHEMBL174229C20H15NO4S365.4036 / 14.0Yes
176602D structureCHEMBL1627022C27H27BrN5NaO5S636.49710 / 1N/ANo
184452D structureCHEMBL367208C29H34N6O4530.6295 / 54.0No
187352D structureCHEMBL149050C20H22N2O5S2434.5257 / 13.4Yes
189662D structureCHEMBL426413C30H40N6O4548.6885 / 54.2No
191752D structureCHEMBL61211C27H24O7460.4827 / 14.9Yes
191762D structureCHEMBL264543C27H24O7460.4827 / 14.9Yes
191782D structureCHEMBL62395C27H24O7460.4827 / 14.9Yes
196492D structureCHEMBL434082C21H24N2O3S384.4945 / 15.2No
197642D structureCHEMBL157742C27H21NO6455.4666 / 14.9Yes
203902D structureCHEMBL110904C28H42N2O5486.6536 / 13.3Yes
204392D structureCHEMBL172297C31H36N4O7S3672.8312 / 26.1No
216112D structureCHEMBL25854C16H17N3O3S331.396 / 13.0Yes
234962D structureBDBM50284278C109H159N27O32S52519.9341 / 37-6.7No
241522D structureCHEMBL113379C26H32N2O5452.5516 / 11.0Yes
4426422D structureCHEMBL3400988C26H24O7448.4717 / 14.2Yes
252092D structureCHEMBL156269C27H21NO6455.4666 / 14.9Yes
252852D structureCHEMBL88011C24H23ClN2O6S502.9668 / 24.9No
254902D structureCHEMBL8925C28H36N2O6496.6046 / 14.6Yes
256162D structureCHEMBL343867C20H23N3O3S385.4826 / 24.1Yes
259692D structureCHEMBL175545C26H24O6432.4726 / 14.9Yes
276382D structureCHEMBL419367C28H34F4N2O7S618.64113 / 12.5No
286472D structureCHEMBL8677C27H27NO6461.5147 / 12.0Yes
287682D structureCHEMBL114074C29H41N3O6527.6628 / 12.5No
306182D structureCHEMBL359152C22H26N2O4S414.526 / 14.9Yes
309262D structureCHEMBL323789C28H38N2O7S546.6799 / 11.9No
309452D structureCHEMBL92965C27H25NO4S459.566 / 15.4No
4428812D structureCHEMBL3400997C24H19N3O4S445.4938 / 14.3Yes
312462D structureCHEMBL173431C22H18N2O4374.3966 / 13.7Yes
313132D structureCHEMBL322799C28H39N3O7529.6348 / 10.2No
317312D structureCHEMBL91753C25H24N2O4S448.5376 / 24.7Yes
317912D structureCHEMBL9334C28H36N2O6496.6047 / 12.0Yes
322622D structureCHEMBL174573C29H28O10536.53310 / 14.6No
325172D structureCHEMBL418667C21H20O6368.3856 / 13.9Yes
329492D structureCHEMBL155708C29H26N2O8S562.5939 / 14.0No
335802D structureCHEMBL149060C20H22N2O3S370.4675 / 14.8Yes
339052D structureCHEMBL331577C25H32N2O5440.546 / 10.9Yes
345132D structureCHEMBL96644C25H25N3O6S495.557 / 13.2Yes
347022D structureCHEMBL368461C29H32FN5O5549.6037 / 44.4No
347252D structureCHEMBL105490C21H24N2O3S384.4945 / 14.9Yes
347872D structureCHEMBL366544C30H42N6O4550.7045 / 54.7No
351942D structureCHEMBL368558C30H40N2O6524.6587 / 12.6No
370742D structureCHEMBL26079C19H19N3O4S385.4386 / 12.7Yes
373122D structureCHEMBL304460C18H18ClN3O6S3503.9879 / 23.6No
375792D structureCHEMBL300066C24H27N3O4S2485.6178 / 15.3No
375892D structureCHEMBL174818C31H41N5O7595.6978 / 44.2No
390622D structureCHEMBL177221C26H22O7446.4557 / 14.7Yes
390922D structureCHEMBL29705C17H19N3O3S345.4176 / 13.1Yes
401752D structureCHEMBL148853C22H26N2O4S414.526 / 15.2No
404282D structureCHEMBL368853C29H32FN5O5549.6037 / 44.4No
408052D structureCHEMBL417050C24H18O6402.4026 / 14.2Yes
422012D structureCHEMBL315752C24H25ClN2O4440.9245 / 16.1No

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