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| Name | Adenosine receptor A1 |
|---|---|
| Species | Homo sapiens (Human) |
| Gene | ADORA1 |
| Synonym | RDC7 A1 receptor A1-AR A1R adenosine receptor A1 |
| Disease | Cardiac arrhythmias Hypertension Cardiac disease Cognitive disorders Diabetes [ Show all ] |
| Length | 326 |
| Amino acid sequence | MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD |
| UniProt | P30542 |
| Protein Data Bank | 6d9h, 5n2s |
| GPCR-HGmod model | P30542 |
| 3D structure model | This structure is from PDB ID 6d9h. |
| BioLiP | BL0385576, BL0417675 |
| Therapeutic Target Database | T88714, T92072 |
| ChEMBL | CHEMBL226 |
| IUPHAR | 18 |
| DrugBank | BE0000013 |
You can:
| GLASS ID | Molecule | Formula | Molecular weight | H-bond acceptor / donor | XlogP | Lipinski's druglikeness |
|---|---|---|---|---|---|---|
| 45 |  CHEMBL574416 | C17H12N4O | 288.31 | 3 / 1 | 2.7 | Yes |
| 69 |  Pyrimidin-4-ylacetamide, 26 | C19H24N6O2 | 368.441 | 6 / 1 | 2.0 | Yes |
| 187 |  CHEMBL473650 | C21H14N6O2 | 382.383 | 5 / 1 | 2.8 | Yes |
| 238 |  CHEMBL437168 | C26H26ClN7O6 | 567.987 | 10 / 5 | 2.2 | No |
| 365 |  CHEMBL573125 | C28H31ClN6O5 | 567.043 | 9 / 4 | 2.5 | No |
| 547903 |  CHEMBL3938269 | C19H14ClN3 | 319.792 | 3 / 1 | 4.6 | Yes |
| 476 |  CHEMBL38304 | C28H32N6O4 | 516.602 | 6 / 2 | 3.2 | No |
| 690 |  CHEMBL196259 | C16H16N8 | 320.36 | 6 / 1 | 2.3 | Yes |
| 521465 |  CHEMBL3827623 | C26H36N6O3 | 480.613 | 6 / 0 | 3.9 | Yes |
| 799 |  CHEMBL2170801 | C22H30ClN5O2 | 431.965 | 6 / 3 | 4.2 | Yes |
| 800 |  CHEMBL468370 | C16H11N3O | 261.284 | 4 / 1 | 3.2 | Yes |
| 808 |  CHEMBL2089347 | C27H24ClN5O2 | 485.972 | 6 / 3 | 4.2 | Yes |
| 829 |  CHEMBL382194 | C18H20IN7O4 | 525.307 | 8 / 5 | 0.4 | No |
| 871 |  CHEMBL481383 | C20H23N5O2 | 365.437 | 3 / 0 | 3.6 | Yes |
| 936 |  2-amino-4-(1,3-benzodioxol-5-yl)-6-methoxypyridine-3,5-dicarbonitrile | C15H10N4O3 | 294.27 | 7 / 1 | 2.2 | Yes |
| 991 |  CHEMBL1927632 | C8H7N7O | 217.192 | 7 / 2 | -0.1 | Yes |
| 997 |  CHEMBL208311 | C25H30N6O4 | 478.553 | 8 / 4 | 2.7 | Yes |
| 1044 |  Pyrimidin-4-ylacetamide, 9 | C20H24N6O3 | 396.451 | 7 / 1 | 1.7 | Yes |
| 1091 |  CHEMBL609297 | C15H19ClN4OS | 338.854 | 5 / 4 | N/A | N/A |
| 1202 |  CHEMBL178846 | C22H25ClN6O5 | 488.929 | 9 / 4 | 1.3 | Yes |
| 463133 |  CHEMBL3613140 | C24H16ClN5O2S | 473.935 | 8 / 1 | 5.2 | No |
| 1448 |  CHEMBL3121728 | C27H31ClN6O3 | 523.034 | 6 / 1 | 3.6 | No |
| 1478 |  CHEMBL1650163 | C18H13F2N3O | 325.319 | 5 / 1 | 3.2 | Yes |
| 1546 |  SCHEMBL1497826 | C22H20Cl3N3OS | 480.832 | 5 / 1 | 6.5 | No |
| 441733 |  CID 118733042 | C10H8N4OS | 232.261 | 4 / 1 | 1.1 | Yes |
| 1715 |  CHEMBL1094143 | C25H19N5O | 405.461 | 4 / 1 | 4.6 | Yes |
| 1990 |  CHEMBL515442 | C19H20ClIN6O5 | 574.76 | 9 / 4 | 1.7 | No |
| 2123 |  CHEMBL2112158 | C21H23ClN6O3 | 442.904 | 7 / 4 | 1.7 | Yes |
| 2147 |  CHEMBL434692 | C18H14BrNOS | 372.28 | 3 / 1 | 5.8 | No |
| 2241 |  CHEMBL259178 | C16H15N5O2 | 309.329 | 6 / 2 | 1.9 | Yes |
| 557362 |  CHEMBL2312720 | C18H13N3O3 | 319.32 | 4 / 1 | 2.9 | Yes |
| 441765 |  CHEMBL3410319 | C23H15F4N5O4 | 501.398 | 11 / 0 | 3.9 | No |
| 2309 |  CHEMBL218837 | C19H20ClN7O5 | 461.863 | 9 / 5 | 0.9 | Yes |
| 2318 |  CHEMBL366216 | C19H25N7 | 351.458 | 6 / 3 | 4.2 | Yes |
| 521525 |  CHEMBL3785142 | C14H17NO3S | 279.354 | 4 / 1 | 1.8 | Yes |
| 463233 |  CHEMBL3613138 | C18H13N5O2S | 363.395 | 7 / 1 | 4.0 | Yes |
| 2994 |  RWJ-68354 | C19H15FN4O | 334.354 | 5 / 2 | 3.3 | Yes |
| 3060 |  CHEMBL376920 | C19H15N3 | 285.35 | 3 / 1 | 4.4 | Yes |
| 3106 |  Pyrimidin-4-ylacetamide, 6 | C22H29N7O2 | 423.521 | 7 / 1 | 2.2 | Yes |
| 3208 |  SCHEMBL4154525 | C17H16F3NOS | 339.376 | 6 / 1 | 5.8 | No |
| 3483 |  CHEMBL56534 | C17H11BrN2O3S | 403.25 | 5 / 1 | 5.6 | No |
| 3620 |  CHEMBL1927430 | C19H28N8O5 | 448.484 | 11 / 3 | 1.0 | No |
| 3674 |  CHEMBL490250 | C17H22ClN5O4 | 395.844 | 8 / 4 | 2.3 | Yes |
| 3790 |  CHEMBL186443 | C19H20N8O4 | 424.421 | 10 / 4 | -0.4 | Yes |
| 3815 |  CHEMBL257256 | C16H18ClN3O2S | 351.849 | 5 / 1 | 3.9 | Yes |
| 3855 |  316173-57-6 | C20H19N7O2 | 389.419 | 7 / 1 | 2.7 | Yes |
| 3959 |  CHEMBL2391832 | C20H13N3O3S | 375.402 | 6 / 1 | 3.8 | Yes |
| 4042 |  CHEMBL428716 | C22H29N7O6 | 487.517 | 11 / 4 | 1.1 | No |
| 517337 |  SCHEMBL246621 | C29H29N5O3S | 527.643 | 8 / 2 | 4.1 | No |
| 4087 |  CHEMBL235717 | C24H18ClN5O3 | 459.89 | 5 / 1 | 5.7 | No |
| 557400 |  CHEMBL3800558 | C37H41N5O4 | 619.766 | 7 / 4 | 5.7 | No |
| 4118 |  CHEMBL465640 | C17H11F3N4 | 328.298 | 6 / 1 | 4.0 | Yes |
| 4209 |  CHEMBL278805 | C22H22Cl2N8O3S | 549.431 | 9 / 1 | 2.7 | No |
| 4239 |  CHEMBL446264 | C8H10BrN5 | 256.107 | 4 / 1 | 1.4 | Yes |
| 4354 |  CHEMBL22355 | C21H17N7O5 | 447.411 | 10 / 2 | 2.2 | Yes |
| 4373 |  CHEMBL56115 | C24H19NOS | 369.482 | 3 / 1 | 6.8 | No |
| 4383 |  CHEMBL3087709 | C23H17N5O2 | 395.422 | 5 / 1 | 3.6 | Yes |
| 4437 |  CHEMBL574490 | C19H13Cl2N7O2 | 442.26 | 6 / 1 | 3.2 | Yes |
| 4514 |  CHEMBL575605 | C31H25N7O2 | 527.588 | 6 / 1 | 5.4 | No |
| 4604 |  CHEMBL3125715 | C22H29N5O2 | 395.507 | 6 / 3 | 3.1 | Yes |
| 4653 |  ethyl 2-amino-4-(3-(trifluoromethyl)phenyl)thiophene-3-carboxylate | C14H12F3NO2S | 315.31 | 7 / 1 | 4.5 | Yes |
| 4684 |  3-(4-bromobenzoyl)-4H,5H,6H-cyclopenta[b]thiophen-2-amine | C14H12BrNOS | 322.22 | 3 / 1 | 4.5 | Yes |
| 521590 |  871266-83-0 | C11H6ClN5O2S | 307.712 | 7 / 1 | 3.7 | Yes |
| 4750 |  CHEMBL27376 | C20H20ClIN6O3 | 554.773 | 7 / 4 | 2.0 | No |
| 4759 |  CHEMBL376778 | C20H19N3O | 317.392 | 3 / 1 | 4.1 | Yes |
| 4816 |  CHEMBL1171381 | C31H37N5O4 | 543.668 | 5 / 0 | 4.4 | No |
| 4836 |  CID 44327951 | C15H18ClN5O3 | 351.791 | 5 / 1 | 1.0 | Yes |
| 4866 |  CHEMBL611552 | C20H22N10O7 | 514.459 | 14 / 5 | -0.1 | No |
| 4869 |  CHEMBL2413111 | C20H22N10O7 | 514.459 | 14 / 5 | -0.1 | No |
| 4871 |  CHEMBL611552 | C20H22N10O7 | 514.459 | 14 / 5 | -0.1 | No |
| 4877 |  CHEMBL1258192 | C22H23N7O2 | 417.473 | 7 / 1 | 3.5 | Yes |
| 4933 |  CHEMBL255861 | C20H15ClN4O3S | 426.875 | 7 / 1 | 3.9 | Yes |
| 4994 |  CHEMBL2042308 | C49H58N8O5 | 839.054 | 10 / 6 | 9.0 | No |
| 441903 |  CHEMBL1766351 | C21H15ClN4O2 | 390.827 | 3 / 2 | 4.1 | Yes |
| 5153 |  CHEMBL1088665 | C23H24N6O | 400.486 | 7 / 2 | 2.1 | Yes |
| 5183 |  CHEMBL565074 | C17H12INOS | 405.253 | 3 / 1 | 5.4 | No |
| 5193 |  triazine-4-carboxamide, 6 | C15H12ClN5O2 | 329.744 | 6 / 2 | 2.1 | Yes |
| 441908 |  CHEMBL3415043 | C13H12N4O2S | 288.325 | 6 / 2 | 2.2 | Yes |
| 463517 |  CHEMBL3612943 | C20H20ClN9O3S | 501.95 | 10 / 4 | 1.0 | No |
| 5374 |  CHEMBL3093315 | C17H17N5O2S | 355.416 | 5 / 0 | 1.4 | Yes |
| 5610 |  UNII-29S2U9DRGS | C27H28N6O5 | 516.558 | 8 / 1 | 5.7 | No |
| 5625 |  CHEMBL589513 | C43H56ClN11O7S | 906.501 | 12 / 9 | 1.2 | No |
| 5627 |  CHEMBL583748 | C43H56ClN11O7S | 906.501 | 12 / 9 | 1.2 | No |
| 5633 |  2-(1-hexynyl)adenosine | C16H21N5O4 | 347.375 | 8 / 4 | 1.3 | Yes |
| 5788 |  CHEMBL108552 | C25H31FN4O5S | 518.604 | 7 / 1 | 5.8 | No |
| 521628 |  CHEMBL3799847 | C20H18ClN5O4S | 459.905 | 8 / 3 | 1.6 | Yes |
| 5906 |  CHEMBL574352 | C13H12N4O | 240.266 | 3 / 1 | 1.4 | Yes |
| 5958 |  CHEMBL220386 | C21H21FN6O5 | 456.434 | 10 / 4 | 1.3 | Yes |
| 5989 |  CHEMBL595981 | C25H32ClN3O5S | 522.057 | 7 / 1 | 4.9 | No |
| 6068 |  CHEMBL255649 | C20H16N4O3S | 392.433 | 7 / 1 | 3.3 | Yes |
| 463628 |  CHEMBL3613133 | C25H19N5O2S2 | 485.58 | 9 / 1 | 5.1 | No |
| 6392 |  triazine-4-carboxamide, 13 | C15H14N6O2 | 310.317 | 7 / 2 | 0.8 | Yes |
| 6462 |  CHEMBL208530 | C12H17N7O4 | 323.313 | 8 / 5 | -1.0 | Yes |
| 441942 |  CHEMBL3314874 | C27H26N6O4 | 498.543 | 8 / 2 | 3.8 | Yes |
| 441945 |  CHEMBL3410309 | C19H21N5O3 | 367.409 | 6 / 1 | 3.0 | Yes |
| 6504 |  CHEMBL142926 | C23H22N8O3 | 458.482 | 7 / 2 | 3.3 | Yes |
| 463670 |  CHEMBL3581311 | C19H26N10O | 410.486 | 7 / 2 | 1.1 | Yes |
| 6699 |  CHEMBL210642 | C18H16N6O3 | 364.365 | 6 / 2 | 1.2 | Yes |
| 6734 |  MRS 1754 | C26H26N6O4 | 486.532 | 6 / 2 | 4.9 | Yes |
| 6821 |  CHEMBL90298 | C19H23N5O3 | 369.425 | 4 / 2 | 3.4 | Yes |
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