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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameAdenosine receptor A2a
SpeciesRattus norvegicus (Rat)
GeneAdora2a
SynonymA2-AR
A2A receptor
adenosine receptor A2a
RDC8
DiseaseN/A for non-human GPCRs
Length410
Amino acid sequenceMGSSVYITVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGVRAKGIIAICWVLSFAIGLTPMLGWNNCSQKDGNSTKTCGEGRVTCLFEDVVPMNYMVYYNFFAFVLLPLLLMLAIYLRIFLAARRQLKQMESQPLPGERTRSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCSTCRHAPPWLMYLAIILSHSNSVVNPFIYAYRIREFRQTFRKIIRTHVLRRQEPFQAGGSSAWALAAHSTEGEQVSLRLNGHPLGVWANGSATHSGRRPNGYTLGLGGGGSAQGSPRDVELPTQERQEGQEHPGLRGHLVQARVGASSWSSEFAPS
UniProtP30543
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL302
IUPHAR19
DrugBankN/A

Known ligands

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Total entries: 2322
Page:  / 24 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
712D structurePyrimidin-4-ylacetamide, 26C19H24N6O2368.4416 / 12.0Yes
5214452D structureCHEMBL3735468C15H12ClN3O285.7314 / 13.3Yes
4752D structureCHEMBL38304C28H32N6O4516.6026 / 23.2No
5332D structureCHEMBL338501C21H14Cl2N4393.2713 / 15.0Yes
6102D structureCHEMBL17202C28H29N5O4499.5715 / 25.5No
6142D structureCID 53633248C28H29N5O4499.5715 / 25.5No
6522D structureCHEMBL323403C24H23NO3S405.5125 / 05.9No
5214692D structureCHEMBL3827623C26H36N6O3480.6136 / 03.9Yes
8992D structureCHEMBL72007C19H20N4O320.3963 / 24.1Yes
10432D structurePyrimidin-4-ylacetamide, 9C20H24N6O3396.4517 / 11.7Yes
11762D structureCHEMBL319971C17H14ClN5O2355.7825 / 13.2Yes
13332D structureMRS-1042C24H28O5396.4835 / 06.0No
14212D structure8-PhenylxanthineC11H8N4O2228.2113 / 30.9Yes
15762D structureCHEMBL366905C15H12N6O292.3026 / 21.5Yes
18972D structureCHEMBL368092C18H21N9O2395.42710 / 21.6Yes
19312D structure2-(3-Cyclopentyl-1-propynyl)adenosineC18H23N5O4373.4138 / 41.8Yes
20232D structureCHEMBL180278C30H33N7O3539.649 / 13.8No
21802D structureCHEMBL343527C18H14N4O4350.3345 / 11.8Yes
31052D structurePyrimidin-4-ylacetamide, 6C22H29N7O2423.5217 / 12.2Yes
33222D structureCHEMBL3093226C21H27N5O3397.4795 / 02.7Yes
34332D structureCHEMBL2113345C17H18N4O4342.3555 / 31.8Yes
38522D structureUNII-63K7WDR6RXC20H19N7O2388.4197 / 12.7Yes
38592D structure316173-57-6C20H19N7O2389.4197 / 12.7Yes
45892D structureCHEMBL79201C14H14N6OS314.3676 / 21.2Yes
47542D structureCHEMBL27376C20H20ClIN6O3554.7737 / 42.0No
51552D structureCHEMBL1095693C12H12N2OS232.3013 / 01.8Yes
52672D structureCHEMBL164039C24H29NO4S2459.6197 / 05.6No
53712D structureCHEMBL3093315C17H17N5O2S355.4165 / 01.4Yes
56292D structure2-(1-hexynyl)adenosineC16H21N5O4347.3758 / 41.3Yes
56572D structureFR-166124C25H22N4O3426.4765 / 12.9Yes
58002D structureCHEMBL392115C19H23N5O3369.4255 / 11.4Yes
5216312D structureCHEMBL3828530C20H26N6O3398.4676 / 01.7Yes
58672D structureCHEMBL72287C22H16N2O324.3833 / 04.0Yes
65412D structureCHEMBL1092868C16H13N7O2S367.3877 / 22.4Yes
66432D structureCHEMBL27773C17H11BrN2O2355.1913 / 04.4Yes
67202D structureCHEMBL608327C18H18ClIN6O4544.7348 / 41.5No
67362D structureMRS 1754C26H26N6O4486.5326 / 24.9Yes
69602D structureCHEMBL387319C18H23N7O2369.4298 / 21.1Yes
69942D structure1,3-DibutylX-7-ribosideC18H35N5O4385.5098 / 4-0.3Yes
70782D structureCHEMBL286479C17H12BrN3O2370.2064 / 13.7Yes
72292D structureCHEMBL424433C15H20N4O4320.3495 / 00.9Yes
72912D structureCID 71508724C15H23N7O8429.3914 / 9-2.7No
74212D structureCHEMBL380914C19H19Cl2N7O5496.3058 / 51.3Yes
79102D structureCHEMBL27502C17H23N5O2329.4046 / 31.5Yes
82222D structureCHEMBL337503C30H31N2O5S+531.6476 / 05.4No
84952D structureCHEMBL66811C24H19N7O2437.4637 / 13.6Yes
85162D structureCHEMBL206807C22H27N7O6485.5019 / 50.6Yes
85192D structureCHEMBL610394C22H27N7O6485.5019 / 50.6Yes
87002D structureCHEMBL98278C20H21N7O4423.4339 / 40.5Yes
89342D structureCHEMBL3291305C20H21N5O347.4225 / 14.1Yes
90352D structureCHEMBL184641C21H23F2N9O455.47411 / 22.8No
90372D structureCHEMBL318264C14H17N7O4347.3359 / 4-1.1Yes
91292D structure172516-44-8C17H24O3S2340.4965 / 05.3No
92492D structureCHEMBL168892C16H14BrN3O344.2123 / 14.3Yes
92772D structureCHEMBL363647C19H18N6O2362.3936 / 22.0Yes
100162D structureCHEMBL223321C23H27ClF3N11O565.9913 / 22.9No
101532D structureCHEMBL2113426C19H23N5O3S401.4858 / 32.3Yes
4593092D structureCHEMBL2158244C15H10FNO2S287.3084 / 12.8Yes
102262D structureCHEMBL413046C26H31N7O6537.5779 / 52.0No
103082D structureCHEMBL177386C19H19Cl2N9O460.3239 / 22.9Yes
103402D structureCHEMBL609543C14H21N5O5339.3529 / 4-0.5Yes
106522D structureCHEMBL315562C16H11FN8O350.3178 / 12.3Yes
106662D structureCHEMBL444281C25H27N5O5477.5216 / 34.8Yes
110302D structure3-Isobutyl-1-methylxanthineC10H14N4O2222.2483 / 11.5Yes
110352D structureCHEMBL2113469C19H29N5O3S407.5338 / 33.0Yes
111362D structureCHEMBL163813C26H34ClNO3S476.0725 / 08.2No
112952D structure2-(furan-2-yl)-5-(methylthio)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-amineC9H8N6OS248.2647 / 11.1Yes
113522D structureCHEMBL606228C19H28N4O4376.4577 / 42.8Yes
114392D structureCHEMBL2113704C16H15IN6418.2425 / 12.7Yes
115182D structureCHEMBL2113685C16H18IN5O2S471.3177 / 32.0Yes
116262D structureCHEMBL475146C23H23N5O3417.4696 / 13.4Yes
119952D structure5'-ChloroAdoC9H10ClN5O3271.6617 / 3-0.2Yes
122202D structureCHEMBL520297C24H25FN6O4S512.568 / 22.0No
122312D structureCHEMBL337629C12H14O3S2270.3615 / 03.1Yes
131792D structureCHEMBL2113493C10H12N6O6312.24210 / 4-0.9Yes
138082D structureArborinineC16H15NO4285.2995 / 13.3Yes
138342D structure(E)-8-(2,4-Dimethoxystyryl)-1,3-diethyl-7-methylxanthineC20H24N4O4384.4365 / 02.5Yes
5218662D structureCHEMBL3828002C24H33N5O3439.565 / 14.2Yes
139202D structure9-(3-chlorophenyl)-1,3-dimethyl-6,7,8,9-tetrahydropyrimido[2,1-f]purine-2,4(1H,3H)-dioneC16H16ClN5O2345.7874 / 02.3Yes
140212D structureCHEMBL142962C20H20N4O332.4074 / 13.8Yes
140732D structureCHEMBL187810C21H25N9O419.4939 / 22.6Yes
141662D structureCHEMBL2113702C13H11ClIN5399.624 / 13.5Yes
144772D structureCHEMBL78317C23H30N4O3410.5184 / 04.4Yes
147602D structureCHEMBL129406C16H14N2234.3022 / 03.6Yes
148392D structureCHEMBL310097C22H21ClN4376.8883 / 15.3No
148422D structureCHEMBL83863C22H21ClN4376.8883 / 15.3No
151842D structureCHEMBL133103C15H16N6OS328.3946 / 22.2Yes
155192D structureCHEMBL337081C11H14N2O3S254.3046 / 22.4Yes
163562D structureCHEMBL2113547C17H24ClN5O4397.868 / 31.4Yes
163902D structureCHEMBL338723C17H19N5OS2373.4936 / 13.8Yes
164712D structureCHEMBL187071C22H23F3N8O472.47611 / 12.9No
165892D structureCHEMBL67026C19H17N7O2375.3927 / 22.4Yes
166402D structureBDBM110138C16H15BrN4O2375.2263 / 02.6Yes
166532D structureCHEMBL3093310C19H19N5O2349.3944 / 01.7Yes
166882D structureCHEMBL262924C29H30ClN7O3560.0559 / 14.1No
168702D structureCHEMBL98828C24H27ClN6O4498.9687 / 24.0Yes
169792D structureCHEMBL610992C19H29N5O5407.4719 / 42.7Yes
170032D structureCHEMBL439141C16H20N8O340.3918 / 11.5Yes
170542D structureCHEMBL187366C19H17F3N8O430.39511 / 12.3No
173692D structureCHEMBL363660C22H24F2N8O454.48610 / 12.8Yes

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