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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameGastrin-releasing peptide receptor
SpeciesHomo sapiens (Human)
GeneGRPR
SynonymGRP-R
GRP-preferring bombesin receptor
gastrin-releasing peptide receptor
BB2 receptor
BB2
DiseaseSolid tumours
Breast cancer
Cancer
Irritable bowel syndrome
Length384
Amino acid sequenceMALNDCFLLNLEVDHFMHCNISSHSADLPVNDDWSHPGILYVIPAVYGVIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLITCAPVDASRYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAAFIWIISMLLAIPEAVFSDLHPFHEESTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLSIISVYYYFIAKNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIRSHSTGRSTTCMTSLKSTNPSVATFSLINGNICHERYV
UniProtP30550
Protein Data BankN/A
GPCR-HGmod modelP30550
3D structure modelThis predicted structure model is from GPCR-EXP P30550.
BioLiPN/A
Therapeutic Target DatabaseT99816
ChEMBLCHEMBL4959
IUPHAR39
DrugBankN/A

Known ligands

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Total entries: 229
Page:  / 3 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
40512D structureCHEMBL313030C35H41N5O4595.7444 / 47.4No
40712D structurePD 168368C31H34N6O4554.6515 / 45.2No
53092D structureCHEMBL88174C32H44N4O2516.732 / 37.2No
89152D structureCHEMBL316085C31H34ClN5O2544.0963 / 46.0No
5479872D structureCHEMBL3908441C67H106N20O20S21575.8224 / 20-4.7No
5363042D structureSCHEMBL1251302C68H100N18O18S1489.7224 / 16-7.2No
119742D structureCHEMBL2429981C78H124FN19O16Si1631.0519 / 19N/ANo
5480372D structureCHEMBL3953851C72H117N25O17S21669.0124 / 21-4.7No
5533252D structureRanatensinC61H84N16O13S1281.515 / 140.4No
163052D structureCHEMBL2429980C74H115FN16O20S2Si1660.0322 / 17N/ANo
173302D structureCHEMBL315660C31H42N4O2502.7032 / 46.8No
5364682D structureCHEMBL3951222C68H98ClN19O18S1537.1624 / 17-7.3No
204612D structureCHEMBL3144503C32H35N5O4553.6634 / 52.6No
204642D structureCHEMBL417947C32H35N5O4553.6634 / 52.6No
205472D structureCHEMBL1907865C35H42N4O2550.7472 / 47.1No
205502D structureCHEMBL315859C35H42N4O2550.7472 / 47.1No
5481202D structureCHEMBL3960301C68H105N21O19S21584.8425 / 19-6.5No
5481292D structureCHEMBL3922805C69H111N23O17S21598.9125 / 20-4.8No
5481412D structureCHEMBL3914573C68H106N20O21S21603.8325 / 20-6.8No
5481452D structureCHEMBL3943104C67H107N21O19S21574.8425 / 20-5.0No
5481482D structureCHEMBL3917426C70H112N20O21S21633.9125 / 19-4.4No
280282D structureCompound GRPC130H203N37O32S22860.439 / 36-3.9No
354062D structureUniversal ligandC57H76N14O111133.3213 / 142.1No
5369192D structureCHEMBL3928975C71H97N19O18S1536.7324 / 17-7.7No
393242D structureCHEMBL269432C51H72N10O121017.213 / 113.2No
471642D structureCHEMBL92274C31H42N4O4534.7014 / 45.1No
5484952D structureCHEMBL3980591C106H171N25O27S2259.7434 / 25-7.7No
5535102D structurebantag-1C49H82N8O7+2895.2448 / 85.2No
5373852D structureSCHEMBL1251393C85H131N19O19S1755.1625 / 17-4.0No
5485862D structureCHEMBL3891981C68H99N19O19S1518.7125 / 18-8.3No
625742D structureCHEMBL313829C33H40N4O2524.7092 / 46.8No
639372D structureCHEMBL87846C32H35N5O5569.6625 / 55.9No
5375202D structureSCHEMBL1392465C85H133N19O20S1773.1726 / 19-5.0No
5486522D structureCHEMBL3978275C68H106N20O21S21603.8325 / 20-6.8No
5486742D structureCHEMBL3924852C70H113N21O19S21616.9224 / 20-3.9No
5487202D structureCHEMBL3942065C59H91N17O16S1326.5422 / 15-8.1No
5377182D structureSCHEMBL1251567C85H133N19O19S1757.1725 / 18-3.7No
5487282D structureCHEMBL3954296C70H113N23O19S21644.9424 / 21-4.9No
5487362D structureCHEMBL3906914C69H110N22O18S21599.924 / 20-4.6No
735902D structureCHEMBL312926C33H37N5O5583.6895 / 46.2No
5378332D structure55749-98-9C38H57N11O7S812.00410 / 101.0No
780232D structureCHEMBL328591C32H44N4O2516.732 / 37.2No
806892D structureCHEMBL89153C32H44N4O2516.732 / 47.2No
5488582D structureCHEMBL3974259C72H115N21O22S21690.9626 / 20-5.0No
5488822D structureCHEMBL3956432C72H116N22O19S21657.9725 / 19-4.2No
844572D structureCHEMBL1907682C37H46N4O2578.8012 / 48.0No
5488962D structureCHEMBL3954412C88H115N19O19S1775.0625 / 17-2.9No
5489872D structureCHEMBL3953118C69H109N21O21S21632.8825 / 21-5.4No
5490582D structureCHEMBL3946856C67H107N21O18S21558.8423 / 21-4.3No
5490662D structureCHEMBL3962352C69H108N20O21S21617.8625 / 20-6.5No
5384162D structureCHEMBL3890803C71H98N18O18S1523.7324 / 17-6.8No
998502D structureCHEMBL525577C57H76N14O101117.3212 / 132.5No
5491022D structureCHEMBL3908400C70H112N24O17S21625.9424 / 20-4.6No
5384652D structureCHEMBL3894747C68H100N20O18S1517.7325 / 18-7.1No
5491192D structureCHEMBL3905562C69H109N21O21S21632.8825 / 21-5.4No
5491202D structureCHEMBL3921363C69H110N22O20S21631.8926 / 21-5.6No
5491422D structureCHEMBL3985283C72H101N19O18S1552.7824 / 17-6.7No
5491882D structureCHEMBL3969439C69H108N20O20S21601.8624 / 19-4.4No
5491902D structureCHEMBL3909253C70H110N22O19S21627.9125 / 20-6.7No
5386282D structureSCHEMBL1250067C69H101N19O18S1516.7424 / 17-7.6No
5492402D structureCHEMBL3944194C61H82N16O14S1295.4817 / 17-0.6No
5492562D structureCHEMBL3978062C67H103N19O18S1494.7424 / 16-8.4No
5492732D structureCHEMBL3901669C72H116N22O20S21673.9725 / 21-4.6No
1142732D structureCHEMBL314375C45H67N13O10S982.17212 / 120.0No
5492912D structureCHEMBL3956532C72H117N23O17S21640.9925 / 20-3.8No
5493042D structureCHEMBL3967904C79H117N25O21S1785.0225 / 26-6.9No
5493172D structureCHEMBL3917120C73H105N21O18S1596.8326 / 15-8.1No
1190832D structureSurinabantC23H23BrCl2N4O522.2683 / 17.0No
5493772D structureCHEMBL3911959C63H99N18O17S+1412.6523 / 15-8.3No
5390012D structureCHEMBL3975022C69H98N20O17S1511.7324 / 17-7.0No
5390202D structureSCHEMBL14959373C94H137N27O26S2093.3533 / 26-11.3No
5391432D structureSCHEMBL1252671C69H101N19O18S1516.7424 / 16-7.8No
5392022D structureSCHEMBL1252293C68H99N19O18S1502.7124 / 17-8.0No
5392252D structureSCHEMBL2292312C89H141N19O22S1861.2828 / 19-5.3No
5495622D structureCHEMBL3952732C69H100N18O18S1501.7325 / 16-7.7No
1325202D structureCHEMBL89734C33H37N5O5583.6895 / 46.2No
1334652D structureCHEMBL272335C57H91N15O11S1194.5114 / 141.4No
1335062D structureBDBM50279043C69H106N24O19S1607.8222 / 23-6.8No
1354352D structureCHEMBL414307C61H94N18O12S1303.618 / 17-1.5No
5394032D structureSCHEMBL1252416C68H99N19O18S1502.7124 / 17-8.0No
1360172D structureCHEMBL90614C32H34F3N5O2577.6526 / 46.3No
5394292D structureCHEMBL3927340C65H95N19O16S21462.7120 / 18-1.7No
1373722D structureCHEMBL505216C56H87N17O13S21270.5417 / 17-1.6No
1373732D structureCHEMBL2372320C56H87N17O13S21270.5417 / 17-1.6No
5496222D structureCHEMBL3894546C87H115N19O18S1747.0524 / 17-2.6No
5496272D structureCHEMBL3891679C80H115N19O20S1694.9726 / 17-6.3No
5496412D structureCHEMBL3929807C77H121N19O18S1632.9924 / 17-3.2No
5395622D structureSCHEMBL1250077C68H100N18O17S1473.7223 / 16-7.4No
5496712D structureCHEMBL3969493C69H108N20O21S21617.8625 / 20-6.5No
5496762D structureCHEMBL3944228C69H109N21O19S21600.8824 / 21-6.0No
5539922D structureRc-3095C56H79N15O91106.3412 / 142.2No
1453752D structureCHEMBL1079517C25H30N2O3406.5264 / 35.0Yes
5497512D structureCHEMBL3967299C68H102N19O20PS1568.7126 / 18-9.3No
1477432D structureCHEMBL89813C31H34N6O4554.6515 / 45.8No
5497692D structureCHEMBL3945599C65H101N19O17S1452.724 / 15-8.8No
4477842D structureCHEMBL3401466C70H104BF3N20O131501.5321 / 15N/ANo
4477852D structureCHEMBL3401467C70H104BF3N20O131499.5421 / 15N/ANo
5400672D structureCHEMBL3974200C67H98N20O18S1503.725 / 17-8.7No
1588382D structureCHEMBL313114C26H34N4O2434.5842 / 44.8Yes
1653182D structureCHEMBL87079C31H35N5O2509.6543 / 45.4No

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