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GPCR

NameSomatostatin receptor type 1
SpeciesHomo sapiens (Human)
GeneSSTR1
SynonymSRIF-2
SS-1-R
SS1-R
SS1R
SST1 receptor
DiseaseAlzheimer disease
Cushing's disease
Neuroendocrine cancer
Length391
Amino acid sequenceMFPNGTASSPSSSPSPSPGSCGEGGGSRGPGAGAADGMEEPGRNASQNGTLSEGQGSAILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARYRRPTVAKVVNLGVWVLSLLVILPIVVFSRTAANSDGTVACNMLMPEPAQRWLVGFVLYTFLMGFLLPVGAICLCYVLIIAKMRMVALKAGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQDDATVSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLSWMDNAAEEPVDYYATALKSRAYSVEDFQPENLESGGVFRNGTCTSRITTL
UniProtP30872
Protein Data BankN/A
GPCR-HGmod modelP30872
3D structure modelThis predicted structure model is from GPCR-EXP P30872.
BioLiPN/A
Therapeutic Target DatabaseT16633
ChEMBLCHEMBL1917
IUPHAR355
DrugBankBE0000452

Known ligands

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Total entries: 926
Page:  / 10 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
6412D structureCHEMBL2112935C23H21N5367.4563 / 23.9Yes
8062D structureCHEMBL406000C60H74N12O101123.3311 / 123.1No
12872D structureBIM 23197C57H81N13O13S31252.5319 / 140.0No
44882D structureCHEMBL1076717C31H39F2N3O3539.6687 / 06.1No
46762D structureCHEMBL29102C33H43NO6549.7087 / 14.2No
4419282D structureCHEMBL3350903C55H68N12O12S21153.3416 / 15-0.2No
4419342D structureCHEMBL3350904C55H68N12O12S21153.3416 / 15-0.2No
64202D structureCHEMBL412183C55H68N12O12S21153.3416 / 15-0.2No
64272D structureCHEMBL438546C55H68N12O12S21153.3416 / 15-0.2No
75682D structureCHEMBL451932C55H74ClN13O10S21176.8514 / 143.1No
92152D structureCHEMBL1161333C54H65N11O12S21124.315 / 130.3No
92212D structureCHEMBL2093027C54H65N11O12S21124.315 / 130.3No
94552D structureCHEMBL216992C60H78N12O11S21207.4816 / 140.6No
104782D structureCHEMBL2369756C58H69ClN12O9S21177.8314 / 113.8No
104842D structureCHEMBL1794041C58H69ClN12O9S21177.8314 / 113.8No
105412D structureCHEMBL503379C41H48F3N7O7S839.93212 / 5N/ANo
109262D structureCHEMBL92545C31H34N4O2S526.6994 / 24.4No
109312D structureCHEMBL93618C31H34N4O2S526.6994 / 24.4No
115932D structureCHEMBL410047C62H79N13O14S21294.5118 / 16-1.0No
120022D structureCHEMBL502077C78H101ClN18O18S21678.3425 / 18-5.4No
123262D structureCHEMBL265839C76H104N16O18S21593.8823 / 21-0.9No
130772D structureCHEMBL429166C60H73ClN12O8S21189.8913 / 115.4No
133652D structureCHEMBL2011461C46H60N8O7837.0358 / 64.3No
144312D structureCHEMBL1076652C31H40N4O5548.6847 / 05.6No
144322D structureCHEMBL1076653C31H40N4O5548.6847 / 05.6No
144342D structureCHEMBL1076654C31H40N4O5548.6847 / 05.6No
4422242D structureCHEMBL3350882C58H72N12O13S21209.4116 / 150.2No
149412D structureCHEMBL263292C58H72N12O13S21209.4116 / 150.2No
149612D structureCHEMBL504838C35H38F3N5O5665.7149 / 5N/ANo
149662D structureCHEMBL462020C35H38F3N5O5665.7149 / 5N/ANo
152102D structureCHEMBL429164C84H111N17O18S21711.0323 / 210.0No
159532D structureCHEMBL254500C26H30BrN5O2524.4634 / 13.1No
159642D structureCHEMBL252231C26H30BrN5O2524.4634 / 13.1No
162982D structureBDBM84629C71H81N11O91232.511 / 128.1No
171202D structureCHEMBL406260C58H70N12O8S21127.3913 / 114.0No
4423322D structureCHEMBL3349676C58H70N12O8S21127.3913 / 114.0No
175852D structureCHEMBL447177C58H72ClN15O13S21286.8817 / 17-1.7No
180972D structureCHEMBL413888C81H106N16O17S21639.9522 / 200.7No
4423822D structureCHEMBL3349610C52H71N11O10S21074.3314 / 131.9No
185442D structureCHEMBL2370299C52H71N11O10S21074.3314 / 131.9No
189512D structureCHEMBL3122128C81H111N17O23S21754.9930 / 19-9.1No
190092D structureSA VC46H62N8O6823.0528 / 84.6No
199172D structureCHEMBL1223226C51H68N10O10981.16512 / 131.7No
206362D structureCHEMBL414544C57H69N9O11S21120.3515 / 122.2No
206392D structureCHEMBL2371100C57H69N9O11S21120.3515 / 122.2No
206462D structureCHEMBL2371108C57H69N9O11S21120.3515 / 122.2No
4424802D structureCHEMBL3350357C57H69N9O11S21120.3515 / 122.2No
206522D structureCHEMBL414272C57H69N9O11S21120.3515 / 122.2No
206552D structureCHEMBL428281C57H69N9O11S21120.3515 / 122.2No
206612D structureCHEMBL2111200C57H69N9O11S21120.3515 / 122.2No
206672D structureCHEMBL2111257C57H69N9O11S21120.3515 / 122.2No
206692D structureCHEMBL264046C57H69N9O11S21120.3515 / 122.2No
206772D structureCHEMBL415582C57H69N9O11S21120.3515 / 122.2No
246842D structureCHEMBL387005C73H99IN16O15S21631.7220 / 181.9No
250792D structureCHEMBL384836C50H67N11O11S21062.2715 / 130.4No
255892D structureCHEMBL440074C81H105IN16O17S21765.8522 / 201.4No
261672D structureCHEMBL176730C30H31N5461.6132 / 36.2No
267462D structureCHEMBL434159C27H28N6OS484.6226 / 23.7Yes
4427292D structureCHEMBL3349599C56H62N8O8975.169 / 85.5No
275992D structureCHEMBL409754C58H70N12O9S21143.3914 / 123.6No
4427392D structureCHEMBL3349669C58H70N12O9S21143.3914 / 123.6No
280802D structuresst4-selective analogue 17C53H62N11O12S2-1109.2615 / 131.2No
286132D structureSA IIC38H54N8O6718.98 / 92.6No
286282D structureBDBM50136762C55H67N12O11S2-1136.3315 / 113.7No
288042D structureCHEMBL2369735C56H68ClN13O9S21166.8114 / 122.6No
288082D structureCHEMBL1793861C56H68ClN13O9S21166.8114 / 122.6No
290132D structureCHEMBL282129C42H51N3O5677.8867 / 36.0No
4428552D structureCHEMBL3349508C66H78ClN11O101220.8712 / 136.6No
305412D structureCHEMBL1793962C66H78ClN11O101220.8712 / 136.6No
4428572D structureCHEMBL3349506C66H78ClN11O101220.8712 / 136.6No
305482D structureCHEMBL1793960C66H78ClN11O101220.8712 / 136.6No
309182D structureCHEMBL3122125C82H126N22O27S21916.1635 / 26-14.6No
338652D structureCHEMBL437448C54H66Br2N12O8S21235.1313 / 114.1No
5583852D structureBDBM144778C95H123N19O10S21755.2718 / 178.8No
5483132D structureCHEMBL3982815C95H123N19O10S21755.2726 / 1711.2No
362722D structureCHEMBL502219C59H70ClN13O10S21220.8614 / 143.2No
362882D structureCHEMBL442605C28H35N5O3489.624 / 42.3Yes
373882D structureCHEMBL1794043C60H71N13O9S21182.4314 / 123.3No
373952D structureCHEMBL2369758C60H71N13O9S21182.4314 / 123.3No
375702D structureCHEMBL408471C56H67N11O9S21102.3412 / 113.9No
376542D structureCHEMBL414446C57H68IN9O10S21230.2514 / 113.2No
376602D structureCHEMBL407649C57H68IN9O10S21230.2514 / 113.2No
385752D structureCHEMBL538948C61H72IN11O10S21310.3414 / 134.5No
385822D structureCHEMBL538948C61H72IN11O10S21308.3414 / 134.5No
392912D structureL-362855C57H70N10O81023.259 / 115.7No
404062D structureCHEMBL559022C74H96IN15O15S21626.720 / 193.5No
404112D structureCHEMBL559022C74H96IN15O15S21624.720 / 193.5No
404442D structureCHEMBL267054C51H70N10O10983.18112 / 131.7No
408942D structureCHEMBL3218121C36H50N6O5646.8336 / 30.8No
413322D structureCHEMBL436962C61H78N12O14S21267.4818 / 160.1No
413852D structureCHEMBL439077C63H76N12O12S21257.4917 / 151.4No
413882D structureCHEMBL437085C63H76N12O12S21257.4917 / 151.4No
4433182D structureCHEMBL3350894C63H76N12O12S21257.4917 / 151.4No
4433232D structureCHEMBL3350893C63H76N12O12S21257.4917 / 151.4No
419882D structureCHEMBL508585C70H92N16O20S21541.7227 / 17-6.0No
430942D structureCHEMBL2112223C30H37N5O2499.6593 / 43.9Yes
432692D structureCHEMBL262551C83H111N15O16S21639.0122 / 182.4No
436212D structureCHEMBL466609C34H39N5O3565.7184 / 43.8No
436252D structureCHEMBL476240C34H39N5O3565.7184 / 43.8No
442622D structureCHEMBL444639C77H99N13O15S21510.8320 / 162.9No

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