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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameGonadotropin-releasing hormone receptor
SpeciesHomo sapiens (Human)
GeneGNRHR
Synonymluliberin receptor
GnRH-R
GNRHR1
LHRHR
LHRH receptor
[ Show all ]
DiseaseUterine leiomyoma
Unspecified
Prostate hyperplasia
Prostate disease
Prostate cancer
[ Show all ]
Length328
Amino acid sequenceMANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
UniProtP30968
Protein Data BankN/A
GPCR-HGmod modelP30968
3D structure modelThis predicted structure model is from GPCR-EXP P30968.
BioLiPN/A
Therapeutic Target DatabaseT12475
ChEMBLCHEMBL1855
IUPHAR256
DrugBankBE0000203

Known ligands

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Total entries: 1541
Page:  / 16 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
152D structureCHEMBL1800663C36H32F2N6O4S682.7479 / 25.5No
9192D structureCHEMBL119774C29H34F3N3O3529.6047 / 05.6No
11102D structureCHEMBL437260C88H86F4N16O121635.7522 / 89.5No
15722D structureCHEMBL324759C29H30F2N4O3520.5817 / 04.0No
15742D structureCHEMBL112466C29H30F2N4O3520.5817 / 04.0No
15752D structureCHEMBL113151C29H30F2N4O3520.5817 / 04.0No
22472D structureCHEMBL265879C83H105ClN18O161646.3118 / 163.7No
23572D structureCHEMBL117504C29H34F3N3O3529.6047 / 15.4No
29982D structureCHEMBL416651C29H31ClN6O3547.0566 / 43.6No
32462D structureCHEMBL417645C29H29F3N4O3538.5718 / 04.1No
33662D structureCHEMBL130607C34H31F2N5O4611.6510 / 05.1No
36352D structureCHEMBL219461C78H103ClN18O161584.2418 / 172.4No
36712D structureCHEMBL468551C28H24F5N3O3545.519 / 14.5No
39902D structureCHEMBL1091579C28H34N6O2486.625 / 14.2Yes
40392D structureCHEMBL22937C32H30F2N4O2540.6156 / 05.3No
42742D structureCHEMBL181582C27H25N3O4455.5145 / 13.1Yes
46212D structureCHEMBL113432C39H50N4O2606.8554 / 36.7No
47432D structureCHEMBL50546C34H38FN5O2567.7097 / 06.3No
53502D structureCHEMBL401418C37H54N6O2S646.9397 / 34.8No
66032D structureAbarelixC72H95ClN14O141416.0916 / 133.7No
70962D structureCHEMBL411381C79H104ClN19O181643.2719 / 191.8No
71952D structureCHEMBL71793C36H40FN5O5641.7449 / 15.9No
74252D structureCHEMBL372316C24H31N5O4S485.6036 / 24.8Yes
76362D structureCHEMBL392604C31H31Cl2F2N5O2614.5197 / 04.7No
87402D structureCHEMBL116074C30H30F3N3O3537.5837 / 05.2No
90092D structureCHEMBL407023C64H103N21O131374.6618 / 18-1.0No
99302D structureCHEMBL73454C27H25F4N3O5547.50710 / 2N/ANo
103772D structureRelugolixC29H27F2N7O5S623.63611 / 23.2No
105712D structureCHEMBL211731C36H36F2N4O3S642.7668 / 26.9No
106172D structureCHEMBL420051C41H54N4O618.913 / 29.1No
112362D structureCHEMBL411565C84H106ClN17O161645.3218 / 164.0No
112972D structureCHEMBL212207C33H32N2O4S552.6897 / 06.6No
113022D structureCHEMBL439076C49H50F2N8O6884.98611 / 46.7No
114572D structureCHEMBL2370818C74H106ClN23O121545.2622 / 184.7No
115882D structureCHEMBL235180C40H41F2N13O5821.85114 / 34.2No
120092D structureCHEMBL238377C43H49F2N13O6881.94715 / 34.1No
120492D structureCHEMBL2113012C25H24F2N4O3466.4896 / 13.2Yes
121432D structureCHEMBL352051C40H47N5O3645.8485 / 45.3No
122362D structureCHEMBL68985C37H34FN5O4631.7089 / 06.0No
123792D structureCHEMBL506338C32H30F5N3O6647.59912 / 22.2No
125092D structureCHEMBL454088C21H21F3N6OS462.4958 / 33.2Yes
125572D structureCHEMBL291896C33H32F2N6O5630.65310 / 24.4No
126692D structureCHEMBL299348C34H36FN5O4597.6919 / 04.9No
135762D structureCHEMBL185438C28H29ClN4O3S537.0756 / 26.5No
135882D structureCHEMBL364933C26H28N6O4S520.6087 / 24.1No
137962D structureCHEMBL265020C83H103ClN18O181676.320 / 162.7No
144222D structureCHEMBL399857C37H50N4O3S630.8925 / 16.2No
147572D structureCHEMBL120834C33H43ClN4O2563.1835 / 29.0No
149862D structureCHEMBL235519C31H35ClF2N4O2569.0946 / 05.0No
150302D structureCHEMBL1800667C33H34F2N6O6S2712.78811 / 23.9No
152182D structureCID 44398121C82H99ClN20O161656.2719 / 181.9No
152332D structureWAY-207024C30H32N6476.6285 / 15.5No
156182D structureCHEMBL175711C26H21F5N4O4548.4710 / 14.1No
157202D structureCHEMBL365985C26H21F4N3O2483.4677 / 14.1Yes
159282D structureCHEMBL236221C46H53F2N13O8954.0117 / 33.8No
166152D structureCHEMBL301103C31H37FN4O5564.6589 / 04.3No
166722D structureCHEMBL506877C31H30F3N3O5581.5929 / 21.8No
171822D structureCHEMBL116246C27H33N3O2431.584 / 15.8No
176562D structureCHEMBL326510C22H23F2N3O3415.4416 / 12.6Yes
176572D structureCHEMBL322283C22H23F2N3O3415.4416 / 12.6Yes
177432D structureCHEMBL236331C31H32ClF2N5O2580.0777 / 04.1No
177522D structureCHEMBL260750C92H90F4N16O121687.8322 / 610.1No
178502D structureCHEMBL68664C32H31FN4O4554.6228 / 05.2No
187532D structureCHEMBL406337C79H101ClN16O141534.2216 / 154.8No
188592D structureCHEMBL452541C22H23F3N6OS476.5228 / 23.2Yes
190922D structureCHEMBL181864C23H21ClFN3O3S473.9476 / 14.9Yes
198802D structureCHEMBL454089C21H22N6O3S438.5066 / 41.3Yes
203082D structureCHEMBL395225C37H37F4N5O643.7318 / 26.4No
205722D structureCHEMBL392008C86H94F4N20O141707.8228 / 65.8No
207592D structureCHEMBL499849C29H26F4N4O4570.54510 / 30.8No
214572D structureCHEMBL433594C28H30ClN5O3S552.097 / 34.8No
217232D structureCHEMBL180372C25H21ClF2N4O4514.9147 / 13.8No
218112D structureCHEMBL487627C21H18F6N6468.40710 / 24.3Yes
218782D structureCHEMBL117069C36H38F2N4O4628.7219 / 06.7No
225882D structureCHEMBL235302C30H32F2N6O2546.6238 / 02.4No
234432D structureCHEMBL364246C28H31N5O4S533.6476 / 25.5No
242212D structureCHEMBL210277C33H31FN2O4S570.6798 / 06.7No
243022D structureCHEMBL325326C30H30F2N4O3532.5927 / 04.1No
243032D structureCHEMBL431248C30H30F2N4O3532.5927 / 04.1No
251662D structureCHEMBL131665C41H42FN5O4687.8169 / 07.2No
5481692D structureGestrinoneC21H24O2308.4212 / 12.2Yes
253662D structureCHEMBL392688C27H32F2N4O2482.5766 / 03.3Yes
254162D structureCHEMBL468348C24H25N3O3S2467.6026 / 14.7Yes
254852D structureCHEMBL165456C39H47N5O2617.8383 / 46.8No
255492D structureCHEMBL267862C66H99N19O131366.6418 / 160.7No
255992D structureCHEMBL415279C50H50F2N8O6896.99711 / 35.9No
5481722D structureVantasC70H94N18O161443.6319 / 17N/ANo
261302D structureCHEMBL313004C44H58N4O658.9753 / 29.7No
264032D structuregoserelinC59H84N18O141269.4316 / 17-1.5No
264652D structureCHEMBL115965C26H30F3N3O3489.5397 / 14.4Yes
267972D structureCHEMBL384898C82H108ClN17O151607.3218 / 172.8No
267982D structureCHEMBL2370890C82H108ClN17O151607.3218 / 162.4No
4594542D structureUNII-7CDW97HUEXC22H15F3N2O7S508.42411 / 23.4No
275472D structureCHEMBL1766108C29H30ClN5O2516.0426 / 25.4No
278672D structureCHEMBL342396C31H31ClF3N5O5646.06411 / 4N/ANo
283282D structureCHEMBL342908C35H38ClF3N4O5687.15710 / 4N/ANo
284812D structureCHEMBL111933C29H28F3N3O3523.5567 / 14.7No
284992D structureCHEMBL23900C29H30F2N4O3520.5817 / 04.0No
299362D structureCHEMBL197317C26H35N7O5S557.678 / 42.7No
310122D structureCHEMBL324654C38H48N4O2592.8283 / 26.5No

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