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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

Name5-hydroxytryptamine receptor 7
SpeciesRattus norvegicus (Rat)
GeneHtr7
SynonymGPRFO
5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
5-HTx
5-HT7 receptor
5-HT7
[ Show all ]
DiseaseN/A for non-human GPCRs
Length448
Amino acid sequenceMMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNSDHCGKKGHDT
UniProtP32305
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3223
IUPHAR12
DrugBankN/A

Known ligands

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Total entries: 644
Page:  / 7 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
6762D structureCHEMBL1644486C20H19ClN2322.8361 / 14.0Yes
11942D structureCHEMBL12933C25H29N3O2S435.5865 / 04.7Yes
14682D structure4365 CTC14H20N2O232.3272 / 12.7Yes
5554852D structureStrychnine, Nb-oxideC21H22N2O3350.4183 / 01.4Yes
5554962D structureBIMU-8C19H26N4O2342.4433 / 12.5Yes
44552D structureCHEMBL369102C25H31N3O389.5433 / 04.8Yes
49062D structureCHEMBL1644281C20H20N2O304.3932 / 23.0Yes
52422D structureSB-258719C18H30N2O2S338.514 / 03.5Yes
81372D structureCHEMBL390558C28H39N3O3465.6385 / 14.4Yes
5555142D structureBW-723C86C16H18N2OS286.3933 / 23.0Yes
86352D structureTCMDC-139048C21H22N2O318.422 / 13.7Yes
96712D structureBDBM50359431C24H27N3O3405.4984 / 22.8Yes
109042D structureCHEMBL28056C25H22N2350.4652 / 05.2No
5533042D structuretryptamineC10H12N2160.221 / 21.6Yes
110762D structureCHEMBL187088C20H27N3O3S389.5146 / 12.9Yes
112372D structureCHEMBL3085301C25H24N2352.4812 / 05.0Yes
112382D structureCHEMBL188855C25H24N2352.4812 / 05.0Yes
116792D structureCHEMBL224935C27H34N4O430.5964 / 14.2Yes
5555242D structurepropranololC16H21NO2259.3493 / 23.0Yes
124682D structureBDBM50359428C19H26N2O3S362.4885 / 23.4Yes
136342D structureCHEMBL26998C16H25NO247.3822 / 14.1Yes
136822D structure8-OH-DpatC16H25NO247.3822 / 14.1Yes
167632D structureCHEMBL185988C27H27N3O3441.5315 / 03.8Yes
176812D structureCHEMBL243955C28H40N4O448.6554 / 14.6Yes
184062D structureCHEMBL540821C18H20ClN3O329.8282 / 3N/AN/A
193312D structureSCHEMBL2272659C17H19NO2269.3443 / 13.3Yes
200192D structureCHEMBL229179C23H31ClN6O3474.996 / 03.3Yes
5555612D structureimipramineC19H24N2280.4152 / 04.8Yes
212452D structureCHEMBL357800C26H36N2O2S440.6464 / 06.5No
214532D structureBDBM50359429C18H24N2O3S348.4615 / 23.1Yes
223202D structureCHEMBL363466C20H25NO2311.4253 / 04.2Yes
5555692D structuresulpirideC15H23N3O4S341.4266 / 20.6Yes
5533892D structureLISURIDEC20H26N4O338.4552 / 22.7Yes
5555812D structureS-(-)-LisurideC20H26N4O338.4552 / 22.7Yes
263912D structureCHEMBL243953C30H43N3O461.6943 / 16.1No
5555902D structureYohimbineC21H26N2O3354.454 / 22.9Yes
266932D structureCHEMBL157840C24H29N3O4423.5137 / 14.5Yes
5555912D structure7-OH-DPATC16H25NO247.3822 / 14.1Yes
271982D structureCHEMBL2203713C18H22N4S326.4624 / 22.9Yes
283042D structureCHEMBL244162C26H36N4O420.6014 / 23.8Yes
302192D structureLP-211C30H34N4O466.6294 / 15.0Yes
5555962D structuremorphineC17H19NO3285.3434 / 20.8Yes
310932D structureBDBM50359427C21H30N2O3S390.5425 / 24.5Yes
318032D structureCHEMBL362540C22H29N307.4811 / 06.1No
320122D structureSCHEMBL6530503C19H16ClFN2O2S390.8574 / 03.4Yes
5556062D structure4-aminobutyric acidC4H9NO2103.1213 / 2-3.2Yes
331772D structureCHEMBL225441C27H37N3O3451.6115 / 14.0Yes
4670342D structureCHEMBL3590089C27H34N4O3462.5945 / 13.7Yes
334502D structureCHEMBL389842C19H23N5O3369.4254 / 10.6Yes
342442D structureSCHEMBL2272950C20H23NO2309.4093 / 14.2Yes
348172D structureCHEMBL160817C23H27N3O3393.4876 / 14.6Yes
357502D structureCHEMBL275495C21H26N2O322.4522 / 04.3Yes
365442D structureCHEMBL281357C17H17N235.331 / 03.0Yes
365852D structureSCHEMBL6530751C21H21ClN2O4S432.9195 / 03.3Yes
369782D structureCHEMBL2431048C19H28ClN3O4397.95 / 2N/AN/A
5175062D structureCHEMBL141096C21H29NO2327.4682 / 24.2Yes
383092D structureCHEMBL1644485C20H19ClN2322.8361 / 14.0Yes
389232D structureCHEMBL283065C25H25NO2371.483 / 05.1No
396332D structureSCHEMBL2273377C16H14F3NO293.2895 / 13.8Yes
5534462D structureAripiprazoleC23H27Cl2N3O2448.3884 / 14.6Yes
409812D structureCHEMBL1644487C20H18Cl2N2357.2781 / 14.6Yes
410482D structureCHEMBL240729C48H66N4O4763.088 / 010.9No
412702D structureCHEMBL228940C21H27ClN6O3446.9365 / 12.6Yes
421832D structureCHEMBL3640573C15H13Cl2NO294.1752 / 14.6Yes
427582D structureBDBM50359426C22H27N3O2365.4773 / 23.3Yes
430382D structureCHEMBL1644279C20H19FN2306.3842 / 13.4Yes
5556532D structurenaphazolineC14H14N2210.281 / 12.1Yes
5175402D structureCHEMBL137923C17H22O2258.3612 / 13.7Yes
466292D structureCHEMBL222864C26H35N3O2421.5854 / 14.1Yes
477752D structureCHEMBL243744C29H41N3O447.6673 / 15.6No
500132D structureSCHEMBL2273888C17H16N2O264.3283 / 13.0Yes
500602D structureCHEMBL229366C24H33ClN6O3489.0176 / 03.7Yes
505692D structureUNII-87UKL3XE5XC22H26N4O2378.4764 / 02.6Yes
505782D structureCHEMBL285066C22H26N4O2378.4764 / 02.6Yes
509502D structureCHEMBL222489C27H36N4O2448.6114 / 23.3Yes
517962D structureSCHEMBL2277147C17H16N2O264.3283 / 13.0Yes
527252D structureCHEMBL1644488C21H21ClN2336.8631 / 04.4Yes
528222D structureBDBM50359434C20H25N3O3355.4384 / 21.8Yes
551062D structureCHEMBL27251C18H18N2262.3562 / 11.6Yes
551112D structureCHEMBL281048C18H18N2262.3562 / 11.6Yes
5556842D structurefenfluramineC12H16F3N231.2624 / 13.4Yes
567482D structureCHEMBL157362C23H27F3N2O2420.4767 / 15.3No
5556852D structureLY-278,584 maleateC17H22N4O298.393 / 12.4Yes
575092D structureCID 56850927C21H31ClN2O3S427.05 / 2N/AN/A
582182D structureCHEMBL390062C26H35N3O3437.5845 / 13.7Yes
584852D structureCHEMBL273452C23H30N2O350.5062 / 05.1No
586652D structureCHEMBL389110C28H38N4O2462.6384 / 23.6Yes
592332D structureSCHEMBL2278224C19H23NO2297.3983 / 14.1Yes
5176232D structureCHEMBL138043C17H20O3272.3443 / 23.2Yes
5557012D structure2-azaniumylacetateC2H5NO275.0672 / 1-2.8Yes
608962D structureCHEMBL521687C25H35N3O4S2505.6927 / 13.7No
620062D structureSCHEMBL2279377C17H19N237.3461 / 13.7Yes
622222D structurespiperoneC23H26FN3O2395.4785 / 13.0Yes
5557202D structureMELPERONEC16H22FNO263.3563 / 03.3Yes
649592D structureCHEMBL12868C20H26N2O2S358.54 / 04.0Yes
669372D structureSCHEMBL2279423C18H21NO267.3722 / 13.6Yes
5557382D structureMelatoninC13H16N2O2232.2832 / 20.8Yes
4712592D structureCHEMBL3634821C29H28FN3O3485.5597 / 06.2No
674712D structureCHEMBL1926745C21H29N3O3371.4814 / 12.0Yes
677732D structureBDBM50359423C20H24N4O2352.4384 / 21.8Yes

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