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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameMelanocortin receptor 5
SpeciesHomo sapiens (Human)
GeneMC5R
Synonymmelanocortin receptor 5
MC5R
MC5-R
MC5 receptor
MC-2
DiseaseAcne vulgaris
Seborrhea
Length325
Amino acid sequenceMNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD
UniProtP33032
Protein Data BankN/A
GPCR-HGmod modelP33032
3D structure modelThis predicted structure model is from GPCR-EXP P33032.
BioLiPN/A
Therapeutic Target DatabaseT95302
ChEMBLCHEMBL4608
IUPHAR286
DrugBankN/A

Known ligands

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Total entries: 1329
Page:  / 14 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
23502D structureCHEMBL454916C28H38Cl2N4O3549.5375 / 24.8No
5339202D structureCHEMBL3949898C27H39N7O2493.6565 / 42.3Yes
38082D structureCHEMBL235798C26H29N5O427.5522 / 33.3Yes
39672D structureCHEMBL236014C27H36Cl2FN5O2552.5166 / 33.6No
4418632D structureCHEMBL1775057C47H59N13O9950.07110 / 12-0.8No
4418692D structureCHEMBL1775063C47H59N13O9950.07110 / 12-0.8No
4418722D structureCHEMBL1775064C47H59N13O9950.07110 / 12-0.8No
46682D structure120-78-5C14H8N2S4332.4726 / 05.6No
47102D structureCHEMBL2113144C33H37ClN4O2557.1354 / 25.8No
5339272D structureCHEMBL3978574C31H42Cl2N4O2573.6034 / 26.1No
5339302D structureSCHEMBL2344848C35H41N7O2591.765 / 53.7No
64682D structureCHEMBL8825C29H30N2O3454.573 / 25.6No
65232D structureCHEMBL380855C35H43ClFN5O2620.216 / 24.5No
66752D structureCHEMBL267360C45H63N12O9S+948.13410 / 90.4No
5339342D structureCHEMBL3944504C31H42Cl2N4O2573.6034 / 26.1No
68962D structureCHEMBL539306C33H36Cl2N4O3S639.6366 / 3N/ANo
71392D structureCHEMBL365237C31H43Cl2N5O2588.6185 / 34.3No
75892D structureBDBM82410C34H51N9O11S793.89416 / 8-4.1No
77062D structureCHEMBL381739C42H57N11O7827.9888 / 91.2No
5339402D structureCHEMBL3918007C30H34Cl3N5O2S635.0456 / 26.2No
5339432D structureCHEMBL3931459C29H42N4O2478.6814 / 34.8Yes
81772D structureCHEMBL445669C41H51N3O4649.8765 / 37.7No
87602D structureCHEMBL2370967C81H105N21O151612.8619 / 200.2No
89922D structureCHEMBL237070C32H42FN3O503.7063 / 26.3No
90222D structureCID 44363770C79H109N23O141604.8918 / 210.7No
5339482D structureSCHEMBL2344457C33H40N6O3568.7225 / 53.2No
5339492D structureCHEMBL3973070C32H38Cl2N4O2581.5824 / 26.6No
5339512D structureCHEMBL3964629C27H42Cl2N4O2525.5594 / 35.4No
95382D structureCHEMBL1923663C44H54N12O6846.9948 / 101.7No
4420842D structureCHEMBL248700C27H31ClN4O2479.0214 / 23.7Yes
97742D structureCHEMBL237930C29H31N3O437.5872 / 24.7Yes
5339522D structureCHEMBL3931475C34H37BrN4O2613.64 / 35.7No
5339532D structureCHEMBL3979990C37H42N4O2574.7694 / 26.1No
5339542D structureCHEMBL3948861C31H44Cl2N4O2575.6194 / 26.6No
4421002D structureCHEMBL508501C54H69N15O91072.2411 / 120.9No
101452D structureCHEMBL509582C54H69N15O91072.2411 / 120.9No
103752D structureCID 16151595C77H103N21O151562.819 / 22-0.3No
5339582D structureCHEMBL3912035C33H41ClN4O3577.1664 / 35.8No
4593252D structureCHEMBL1196971C31H48FN5O3557.7556 / 33.9No
123932D structureCHEMBL365401C34H51FN4O3582.8055 / 25.4No
123982D structureRY-764C34H51FN4O3582.8055 / 25.4No
124042D structureCHEMBL429387C34H51FN4O3582.8055 / 25.4No
128922D structureCHEMBL2370965C81H107N19O151586.8618 / 190.9No
129132D structureCHEMBL392094C33H40ClN3O3562.1514 / 16.7No
5339682D structureCHEMBL3958801C33H37ClN4O3573.1344 / 36.3No
5339702D structureSCHEMBL2348895C34H39F3N6O2620.7217 / 44.4No
134072D structureCHEMBL267020C28H31N5O453.593 / 33.5Yes
135252D structureAc-YK[CEHdFRWC]-NH2C60H79N17O13S21310.5218 / 17-3.3No
147002D structureCHEMBL2113028C35H54FN5O5643.8457 / 34.8No
4422142D structureCHEMBL385561C47H59N13O7918.0739 / 100.9No
155262D structureCHEMBL397580C31H40Cl2FN5O3620.5916 / 24.1No
157432D structureCID 44363975C73H98N22O13S21555.8519 / 20-0.2No
158952D structureCHEMBL188651C29H39Cl2N5O3S608.6236 / 33.4No
4648692D structureCHEMBL3600838C56H75N15O91102.3111 / 111.6No
162142D structureCHEMBL400456C31H40ClN7O2578.1586 / 25.0No
165372D structureCHEMBL471340C27H36Cl2N4O3535.515 / 34.3No
5339752D structureSCHEMBL2348398C33H39ClN6O2587.1654 / 44.2No
175272D structureCHEMBL425591C47H59N13O7918.0739 / 111.9No
5339782D structureCHEMBL3890817C30H43ClN4O2527.154 / 25.7No
182462D structureCHEMBL249277C33H44ClN7O2606.2126 / 26.3No
186072D structureCHEMBL254757C31H40Cl3N3O2593.033 / 16.4No
187562D structureCHEMBL2028957C37H54F7N5O7813.85616 / 6N/ANo
4652722D structureCHEMBL3600835C55H73N15O91088.2911 / 121.5No
199682D structureCHEMBL381503C34H44ClN5O3606.2084 / 35.3No
201222D structureCHEMBL1209788C33H38ClF2N3O3598.1327 / 04.8No
5339902D structureCHEMBL3906338C30H43FN4O2510.6985 / 25.2No
215292D structureCID 70693082C93H145N27O201961.3526 / 241.5No
5339932D structureSCHEMBL2351596C26H30Cl4N4O2572.3524 / 25.4No
5339952D structureSCHEMBL2349417C33H38N6O2550.7075 / 44.0No
221622D structureCHEMBL237052C24H31N3O377.5322 / 23.8Yes
5339992D structureCHEMBL3958082C33H42N4O2526.7254 / 35.5No
231892D structureCHEMBL467587C28H38Cl2N4O3549.5375 / 25.0No
233092D structureBDBM50389782C96H146N28O252092.431 / 25-3.0No
5340022D structureSCHEMBL2347568C37H42N6O3618.7825 / 44.6No
237832D structureCHEMBL2371963C54H68N10O91001.29 / 83.7No
5340042D structureSCHEMBL2347332C34H42N6O2566.754 / 43.4No
5340052D structureCHEMBL3962578C36H40ClN3O3598.1844 / 26.8No
245832D structureCHEMBL2070248C74H114N18O151495.8416 / 174.0No
246432D structureCHEMBL396111C41H52ClN3O4686.3345 / 38.4No
249682D structureCHEMBL2113280C26H30N6O442.5673 / 42.4Yes
259952D structureCHEMBL403420C35H44ClN3O2574.2063 / 16.4No
5340102D structureCHEMBL3975125C33H43ClN4O4S627.2416 / 35.8No
4662232D structureCHEMBL3600842C56H75N15O91102.3111 / 111.6No
272572D structureCHEMBL2371968C59H76N10O91069.329 / 85.4No
276942D structureCHEMBL394394C39H48FN3O2609.834 / 37.9No
280602D structureBDBM50163151C82H106N20O161627.8720 / 221.8No
290942D structureCHEMBL2113149C35H42ClN5O2600.2045 / 25.2No
293782D structureCHEMBL400252C32H42ClN7O2592.1856 / 25.4No
5340222D structureSCHEMBL2349021C33H38Cl2N6O2621.6074 / 44.8No
5340322D structureCHEMBL3916858C29H38Cl2N4O2545.5494 / 25.3No
318322D structureCHEMBL237937C22H22ClN3O2395.8873 / 23.4Yes
5340372D structureSCHEMBL2347544C31H38N4O2498.6714 / 34.1Yes
333812D structureD0I8SJC90H127N25O26S2007.2131 / 27-10.1No
336462D structureCHEMBL366036C27H35Cl2N5O516.5113 / 35.1No
4429722D structureCHEMBL3421680C34H42N12O5698.7898 / 7-0.9No
340592D structureCHEMBL423101C33H35ClN6O2583.1335 / 24.1No
5340442D structureSCHEMBL2349052C29H32Cl2N4O2539.5014 / 34.6No
5340462D structureCHEMBL3954657C33H39ClN4O2559.1514 / 35.0No
350712D structureCHEMBL234456C54H73N13O101064.2612 / 12-1.1No
353322D structureCHEMBL236840C33H36ClN3O3558.1194 / 16.7No

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