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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameCorticotropin-releasing factor receptor 1
SpeciesRattus norvegicus (Rat)
GeneCrhr1
SynonymCorticotropin-releasing hormone receptor 1
CRH-R-1
CRF1 receptor
CRF-R-1
CRH-R1
[ Show all ]
DiseaseN/A for non-human GPCRs
Length415
Amino acid sequenceMGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
UniProtP35353
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4649
IUPHAR212
DrugBankN/A

Known ligands

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Total entries: 620
Page:  / 7 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
5082D structureCHEMBL455588C20H27N5O3385.4687 / 02.7Yes
17292D structureCHEMBL519340C20H26FN5O371.466 / 15.1No
20492D structureCHEMBL563618C18H21Cl2N3O2382.2853 / 03.8Yes
30052D structureCHEMBL168764C13H14IN3339.183 / 03.7Yes
44952D structurePyridopyrazine, 3bC23H34N4O3414.557 / 14.2Yes
53132D structureCHEMBL2058592C22H22ClF2N3O2433.8846 / 05.4No
5216212D structureCHEMBL3798004C23H23ClF3N5O3509.9149 / 14.3No
60232D structureCHEMBL355289C17H22BrN3348.2883 / 05.2No
65092D structurePyridopyrazinone, 5aC23H30N4O2394.5195 / 14.0Yes
65442D structureCHEMBL541756C19H24ClN3O345.8712 / 14.5Yes
71942D structureCHEMBL2165199C17H19Cl3FN3O4454.7046 / 13.0Yes
74372D structurePyridopyrazine, 1bC22H32N4O368.5255 / 15.1No
85422D structureCHEMBL271373C23H33NO3371.5214 / 15.7No
86692D structureCHEMBL1086508C16H15Cl2F3N4O407.2185 / 14.2Yes
93502D structureCHEMBL474901C22H31N5O2397.5236 / 04.9Yes
93612D structureCHEMBL364883C23H31ClN4O414.9784 / 15.7No
97142D structure195055-03-9C22H32N6380.545 / 04.7Yes
103322D structureCHEMBL1086510C17H17Cl2F3N4O2437.2446 / 13.7Yes
105172D structureCHEMBL584343C18H23ClN4O2362.8584 / 13.4Yes
143102D structureCHEMBL2349560C18H19BrCl2FN3O3495.175 / 14.0Yes
145442D structureCHEMBL426607C21H24Cl2N4O419.353 / 05.2No
149532D structureCHEMBL427971C158H263N47O423493.1348 / 47-9.6No
151652D structureCHEMBL560823C18H22ClN3O2347.8433 / 22.9Yes
156132D structureCHEMBL2058594C22H24FN3O2381.4515 / 03.9Yes
174802D structureCHEMBL2165195C19H23ClFN3O3395.8595 / 13.5Yes
196732D structureCHEMBL355202C25H25N3O383.4953 / 14.5Yes
202632D structureCHEMBL271546C20H26ClNO2347.8833 / 06.7No
212552D structureCHEMBL2058606C21H21ClF2N4O2434.8727 / 04.8Yes
227402D structureCHEMBL201982C26H29N3O3S463.5966 / 15.9No
227612D structureCHEMBL204690C29H30N2O4S502.6296 / 17.0No
229332D structureastressin BC183H305N47O554043.7361 / 54-14.5No
234802D structureCHEMBL565169C18H22ClN3O3363.8424 / 22.5Yes
5223132D structureCHEMBL3797955C23H23ClN6O3466.9267 / 13.1Yes
247202D structureCHEMBL1828889C20H26ClN5O387.9125 / 15.4No
249342D structureCHEMBL166102C15H18BrN3320.2343 / 04.5Yes
253462D structureCHEMBL563819C15H13Cl3N4O2387.6454 / 12.9Yes
268572D structureCHEMBL1762823C19H25FN6O2388.4478 / 02.8Yes
299752D structureCHEMBL560033C17H18Cl3N3O2402.73 / 14.6Yes
311212D structureCHEMBL165818C18H16BrN3354.2512 / 04.8Yes
333772D structureCHEMBL164206C25H34N4390.5753 / 06.6No
335942D structureCHEMBL186203C20H24Cl2N4O407.3394 / 15.2No
5226282D structureSCHEMBL1786667C22H30ClN5O4463.9636 / 23.5Yes
382372D structureCHEMBL574852C18H21ClF2N4O3414.8387 / 13.3Yes
382382D structureCHEMBL572589C18H21ClF2N4O3414.8387 / 13.3Yes
393092D structureCHEMBL360532C23H25ClN4O2424.9294 / 05.1No
396092D structureCHEMBL441750C149H253N49O43S23483.0852 / 49-14.2No
396102D structureCHEMBL408724C149H253N49O43S23483.0852 / 49-14.2No
396112D structureCHEMBL438756C149H253N49O43S23483.0852 / 49-14.2No
396122D structureCHEMBL442300C149H253N49O43S23483.0852 / 49-14.2No
396432D structureCHEMBL1085734C16H18Cl2N4O3S417.3054 / 12.6Yes
423902D structureCHEMBL381824C29H30N2O4S502.6296 / 17.0No
427382D structureCHEMBL2058597C22H21ClN4O392.8874 / 04.2Yes
438492D structureCHEMBL559633C20H28ClN3O361.9142 / 15.3No
443682D structureCHEMBL1082705C18H21N5O323.43 / 12.5Yes
445042D structureCHEMBL453001C17H22N6O326.4046 / 03.0Yes
449402D structureCHEMBL573284C18H21N5O2339.3995 / 11.9Yes
479232D structurePteridine, 5dC22H31N5O381.5246 / 14.5Yes
479632D structureCHEMBL272804C23H33NO2355.5223 / 07.2No
485332D structureCHEMBL115836C30H47Cl3N4Sn688.7944 / 1N/ANo
517232D structureCHEMBL348967C24H33FN4396.5544 / 06.4No
5230542D structureCHEMBL3798497C25H29ClN6O5528.9948 / 23.4No
522342D structureCHEMBL408028C21H29NO3343.4674 / 05.4No
522652D structureCHEMBL1085930C20H26ClN5O387.9124 / 13.5Yes
530142D structureCHEMBL437101C159H263N47O433521.1449 / 47-9.7No
530152D structureCHEMBL436900C159H263N47O433521.1449 / 47-9.7No
544262D structureCHEMBL182169C20H24Cl2N4O407.3393 / 05.4No
547092D structureCHEMBL259467C20H27NO2313.4413 / 05.9No
562222D structureCHEMBL561230C17H16Cl2N4O363.2423 / 13.6Yes
563862D structureCHEMBL2165202C18H24BrN3O4426.3115 / 12.2Yes
565022D structureCHEMBL2058598C22H24ClN3O2397.9034 / 04.4Yes
581562D structureCHEMBL2165201C18H23BrFN3O4444.3016 / 12.7Yes
593222D structureCHEMBL186252C23H31BrN4O459.4324 / 15.8No
604602D structureCHEMBL564968C16H17Cl2N3O338.2322 / 14.0Yes
608212D structureCHEMBL483349C18H24N6O340.4316 / 03.5Yes
616892D structureCHEMBL273033C23H33NO3371.5214 / 06.8No
620162D structureUNII-7FC996ZZL5C21H29N5O3399.4957 / 03.0Yes
628842D structureCHEMBL559437C19H24ClN3O3377.8694 / 13.0Yes
628862D structureCHEMBL560036C19H24ClN3O3377.8694 / 13.0Yes
636882D structureCHEMBL2058604C19H18Cl2N4O389.284 / 04.1Yes
637382D structureCHEMBL10504C20H27BrN6O2463.387 / 03.8Yes
641952D structureCHEMBL2372247C162H270N50O433606.2550 / 49-10.9No
649112D structureCHEMBL1084026C18H24N4O2328.4163 / 12.8Yes
659652D structureCHEMBL1083292C18H22F3N5O2397.4027 / 13.1Yes
663342D structureCHEMBL353075C14H16BrN3306.2073 / 04.1Yes
663432D structureCHEMBL552237C19H26ClN3O347.8872 / 14.8Yes
666032D structureCHEMBL432496C20H27BrN4O419.3675 / 04.9Yes
675442D structureCHEMBL2058589C23H26ClN3O2411.934 / 04.8Yes
684602D structureCHEMBL184938C21H28Cl2N4O423.3823 / 06.3No
720132D structureCHEMBL550216C17H15Cl3F3N3O2456.6716 / 14.5Yes
723512D structureCHEMBL560098C17H22ClN3O2335.8323 / 13.1Yes
726442D structureCHEMBL2165197C16H18Cl3N3O4422.6875 / 12.7Yes
726722D structureCHEMBL355135C18H16BrN3O370.252 / 13.5Yes
729982D structureCHEMBL572588C16H19ClF2N4O3388.87 / 12.9Yes
731382D structureCHEMBL363654C20H24ClFN4O2406.8866 / 14.2Yes
732112D structureCHEMBL49217C19H24N4308.4293 / 14.8Yes
772102D structureCHEMBL182497C23H32Cl2N4O451.4363 / 07.2No
774282D structureCHEMBL561225C18H17F3N4O2378.3557 / 12.4Yes
774632D structureCHEMBL1083590C17H20F3N5O2383.3757 / 12.8Yes
778652D structureCHEMBL519999C22H31N5O2397.5236 / 05.1No
785952D structureCP-154526C23H32N4364.5373 / 06.2No

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