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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameProstaglandin E2 receptor EP4 subtype
SpeciesHomo sapiens (Human)
GenePTGER4
SynonymProstanoid EP4 receptor
PGE2 receptor EP4 subtype
PGE receptor EP4 subtype
EP4 receptor
EP2
DiseaseUlcerative colitis
Glaucoma
Inflammatory disease
Migraine
Osteoarthritis
[ Show all ]
Length488
Amino acid sequenceMSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
UniProtP35408
Protein Data Bank5ywy, 5yhl
GPCR-HGmod modelP35408
3D structure modelThis structure is from PDB ID 5ywy.
BioLiPBL0434347, BL0434289
Therapeutic Target DatabaseT18876
ChEMBLCHEMBL1836
IUPHAR343
DrugBankBE0003522

Known ligands

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Total entries: 1137
Page:  / 12 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
4312D structureCHEMBL2164612C40H43BF4N2O4702.59810 / 1N/ANo
8542D structureCHEMBL180742C26H22Cl2O4469.3584 / 26.4No
5359342D structureCHEMBL3904946C24H25FO4396.4585 / 23.9Yes
5573392D structureSCHEMBL17938360C27H28N4O4S504.6055 / 03.6No
15972D structureCHEMBL207203C23H24ClNO5S461.9575 / 23.0Yes
16282D structureCHEMBL3264203C22H23FN2O350.4372 / 14.6Yes
18222D structureCHEMBL314533C38H34N2O4S614.764 / 17.6No
5573512D structureSCHEMBL17944464C25H23N3O4429.4765 / 33.0Yes
30502D structureCHEMBL3115074C23H28N2O4396.4875 / 21.3Yes
5574092D structureSCHEMBL17938377C32H30N4O4S566.6765 / 15.4No
45462D structureCHEMBL430124C20H27NO4S377.4995 / 22.4Yes
5216012D structureCHEMBL3793009C20H22ClNO6407.8477 / 23.2Yes
5173452D structureCHEMBL3893847C28H35F2NO4S519.6487 / 26.8No
5173472D structureCHEMBL3968443C28H35F2NO4S519.6487 / 26.8No
5574182D structureSCHEMBL15774531C32H30N4O4S566.6765 / 14.9No
5360812D structureCHEMBL354419C20H18N6O2374.4047 / 11.8Yes
65642D structureCHEMBL479439C25H21Cl2F3N2O4S573.4087 / 14.8No
66572D structureCHEMBL313266C27H27NO4S4557.7567 / 16.5No
5216622D structureN-(2,6-dimethylphenyl)-2-phenylquinoline-4-carboxamideC24H20N2O352.4372 / 15.4No
84462D structureCHEMBL417171C21H26F3NO4413.4377 / 23.1Yes
91972D structureCHEMBL123844C27H22O3394.473 / 15.3No
5532962D structureER 819762C30H39N3O3489.664 / 04.5Yes
5575582D structure1-[(2,2-Dimethylcyclopropyl)methyl]-2-(9-ethyl-9H-carbazol-3-yl)-1H-benzimidazole-5-carboxylic acidC28H27N3O2437.5433 / 15.9No
97882D structureCHEMBL1644015C26H32N2O3S452.6134 / 16.1No
103482D structureCID 52944193C52H48O6768.956 / 2N/ANo
106732D structureCHEMBL191874C28H35NO5465.595 / 24.6Yes
116372D structureAH 6809C17H14O5298.2945 / 13.9Yes
123682D structureBDBM50370468C25H22O4386.4474 / 25.5No
5533192D structureCicaprostC22H30O5374.4775 / 32.1Yes
127752D structureCID 53394056C22H30O5374.4775 / 32.1Yes
5576502D structureSCHEMBL15774302C32H31N5O4S581.6916 / 14.3No
131422D structureCHEMBL275245C23H33NO5403.5195 / 22.2Yes
4644632D structureSCHEMBL2350626C22H16Cl2F3NO3S502.3297 / 27.0No
135622D structureCHEMBL125110C26H22O3S414.5194 / 16.1No
4645482D structureCHEMBL3586353C23H19ClN2OS406.9284 / 05.2No
138962D structureCHEMBL181035C24H20O3356.4213 / 15.6No
143402D structureCHEMBL251294C20H27NO4345.4394 / 22.8Yes
143562D structureCHEMBL3264208C22H24N2O3364.4453 / 24.1Yes
145152D structureCHEMBL3260433C19H15NO4321.3324 / 23.7Yes
5363772D structureCHEMBL3896466C26H27F3N2O3472.5087 / 22.6Yes
4422502D structure[(5Z,8R,9S,11R,12R,13E,15S)-9,11,15-Trihydroxy-1-norprosta-5,13-diene-2-yl]phosphinic acidC19H35O5P374.4585 / 41.9Yes
153052D structureCHEMBL180089C26H23FO3402.4654 / 16.4No
163372D structureCHEMBL90491C37H32N2O4S600.7334 / 17.3No
164462D structureCHEMBL3260420C20H17N3O2S363.4355 / 14.9Yes
170522D structureCHEMBL87797C28H28N2O5S2536.6616 / 26.0No
171362D structureCHEMBL2440659C15H11FN4O2S330.3377 / 12.4Yes
4593662D structureSCHEMBL2195516C23H38O5394.5525 / 24.1Yes
179402D structureCHEMBL3286635C22H27N3O349.4782 / 14.2Yes
4593732D structureSCHEMBL2191405C27H34O5S470.6246 / 24.4Yes
5578072D structureSCHEMBL17938384C28H29N3O4471.5575 / 04.3Yes
182022D structureCHEMBL251710C20H25NO3327.4243 / 13.9Yes
5364552D structureSCHEMBL1310801C21H25NO5371.4335 / 13.4Yes
5578862D structureSCHEMBL18357252C30H29ClFNO4522.0135 / 25.7No
5174262D structureCHEMBL3959605C24H33F2NO4437.5286 / 24.5Yes
200572D structureCHEMBL413563C24H35NO5417.5465 / 22.6Yes
5364852D structureSCHEMBL2011904C24H34O4386.5324 / 24.4Yes
202842D structureCHEMBL3260439C20H18O5338.3595 / 14.3Yes
5174302D structureCHEMBL3978072C25H29F2NO4S477.5677 / 15.2No
5174312D structureCHEMBL3911081C25H29F2NO4S477.5677 / 15.2No
5365352D structureCHEMBL3953493C25H25F3N2O3458.4817 / 21.9Yes
5365392D structureSCHEMBL5203473C24H37ClO4425.0064 / 25.4No
221462D structureDG-041C23H15Cl4FN2O3S2592.3025 / 17.8No
5221542D structureCHEMBL3775436C15H26ClNO3303.8274 / 3N/AN/A
5222002D structureCHEMBL3775769C15H26ClNO3303.8274 / 3N/AN/A
5365442D structureCHEMBL3896035C27H36F4N4O5S604.66211 / 25.6No
228002D structureCHEMBL601299C20H14Cl3NO3S454.7464 / 26.4No
230362D structureCHEMBL46395C22H30F3NO4429.487 / 23.9Yes
5533652D structureEP4 antagonist, BTGC26H28N2O6S496.5787 / 14.0Yes
4594192D structureSCHEMBL2194130C24H32O5400.5155 / 33.0Yes
5533792D structureprostaglandin D2C20H32O5352.4715 / 32.6Yes
241722D structureCHEMBL255527C32H32N2O6S572.6766 / 15.1No
242282D structureCHEMBL1669026C36H39N3O6S641.7836 / 27.0No
4426112D structureTalnetantC25H22N2O2382.4633 / 25.7No
4659922D structureCHEMBL3586309C24H22N2O2S402.5125 / 04.5Yes
5366422D structureSCHEMBL671511C29H38F4N4O5S630.711 / 26.2No
5366622D structureSCHEMBL2014800C25H32O4S428.5875 / 25.5No
5366712D structureSCHEMBL1309617C21H25NO4S387.4945 / 14.0Yes
266692D structureMLS000553986C22H17ClFN5O5S3582.03611 / 35.3No
266962D structureONO-AE2-227C27H23NO3409.4853 / 26.0No
275622D structureCID 52945421C50H44O6740.8966 / 2N/ANo
5581202D structureSCHEMBL15774525C27H26N4O422.5322 / 05.0Yes
285022D structureCHEMBL1080281C24H15Cl2F3N4O3S567.3649 / 15.9No
5481992D structureCHEMBL3938316C25H25F3N2O3458.4817 / 22.1Yes
5581242D structureSCHEMBL16584716C25H25F3N2O3458.4817 / 22.1Yes
286882D structureCHEMBL45008C22H28F3NO4427.4647 / 23.4Yes
286932D structureCHEMBL440474C22H28F3NO4427.4647 / 23.4Yes
5224212D structureCHEMBL3793911C23H28N2O4396.4875 / 11.1Yes
5224342D structureCHEMBL3794185C21H23ClO5S422.926 / 24.4Yes
297122D structureCHEMBL1669023C34H36N2O5552.6715 / 15.9No
301732D structureCHEMBL1084047C26H23ClN2O3446.9313 / 25.3No
304402D structureCHEMBL1644005C28H28ClN3O4S2570.1195 / 26.2No
5224792D structureCHEMBL3793002C21H23F2N3O3403.437 / 24.3Yes
308992D structureCHEMBL3260437C20H18O5338.3595 / 14.3Yes
310042D structureCHEMBL208260C21H18ClF2NO2389.8274 / 14.9Yes
315692D structureCHEMBL372894C20H33NO4S383.5475 / 22.7Yes
5482462D structureCHEMBL3964180C24H24F3LiN2O3452.4028 / 1N/AN/A
5582482D structureSCHEMBL16584587C24H24F3LiN2O3452.4027 / 1N/AN/A
4595022D structureSCHEMBL2190873C28H37NO4S483.6675 / 34.2Yes
325412D structureCHEMBL223744C22H31NO4373.4934 / 23.8Yes
326872D structureCHEMBL1645134C25H22Cl2N2O3469.3624 / 25.5No

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