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GPCR

NameNociceptin receptor
SpeciesHomo sapiens (Human)
GeneOPRL1
SynonymOrphanin FQ receptor
OP4
NOPr
NOP-r
NOP receptor
[ Show all ]
DiseaseInflammatory disease
Major depressive disorder
Central nervous system disease
Heart failure
Anxiety disorder
[ Show all ]
Length370
Amino acid sequenceMEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
UniProtP41146
Protein Data Bank5dhh, 5dhg, 4ea3
GPCR-HGmod modelP41146
3D structure modelThis structure is from PDB ID 5dhh.
BioLiPBL0328039,BL0328040, BL0328041,BL0328042, BL0227293,BL0227294
Therapeutic Target DatabaseT52921
ChEMBLCHEMBL2014
IUPHAR320
DrugBankBE0002378

Known ligands

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Total entries: 1670
Page:  / 17 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
1342D structureCHEMBL1762411C35H45N5O2567.7786 / 46.2No
5652D structureCHEMBL438965C25H25ClN2388.9391 / 16.4No
4416972D structureCHEMBL3394753C35H51FN4O4610.8158 / 26.2No
11012D structureCHEMBL541511C19H26F2N4348.4425 / 13.1Yes
17682D structureCHEMBL1186493C23H27ClN4394.9474 / 25.6No
18592D structureCHEMBL260169C31H39N3O3S533.7315 / 06.5No
5215102D structureCHEMBL3785839C24H29N3O375.5162 / 13.6Yes
24242D structureCHEMBL513423C22H26ClFN2O2404.915 / 23.1Yes
34382D structureCHEMBL2113273C24H41N3O387.6122 / 05.2No
34632D structureCHEMBL506803C27H26Cl2FN454.412 / 07.9No
5479402D structureCHEMBL95302C19H23N5O4385.4248 / 42.3Yes
35772D structureCHEMBL259263C30H38N4O3S534.7196 / 05.8No
38642D structureCHEMBL228740C22H23NOS349.4923 / 14.3Yes
39392D structureCHEMBL364398C23H37N3O3S435.6276 / 13.3Yes
40892D structureCHEMBL362240C30H36ClN5O2534.1014 / 15.4No
45742D structureCHEMBL454919C32H36Cl2N2519.5542 / 08.4No
46492D structurearylpyrazole, 13C22H22Cl3N3434.7892 / 16.5No
47162D structureCHEMBL480619C21H31N3325.52 / 05.0Yes
49992D structureCHEMBL369786C25H33N3O2407.5583 / 15.8No
51842D structureCHEMBL481707C29H35N3O441.6193 / 07.1No
55402D structureCHEMBL209380C27H33FN2O420.5723 / 14.9Yes
5339292D structureSCHEMBL3413519C32H38N6O2538.6968 / 16.5No
60212D structureCHEMBL230253C23H31NO337.5072 / 15.3No
61722D structureCHEMBL3262366C34H43NO4529.7215 / 25.8No
5574552D structureCHEMBL210140C22H23FN4O378.4515 / 14.6Yes
67852D structurespiropiperidine analogue, 11C28H31N3O425.5763 / 05.4No
69672D structureCID 69083551C24H29ClN6436.9884 / 35.0Yes
70062D structureCHEMBL3262546C25H30N2O374.5282 / 04.8Yes
71722D structureCHEMBL513303C32H36Cl2N2O535.5533 / 17.5No
76492D structureCHEMBL535844C25H28ClNO393.9552 / 2N/AN/A
84172D structurearylpyrazole, 26C21H23Cl2N5416.354 / 14.4Yes
87542D structureCHEMBL320991C20H30ClNO335.9162 / 15.5No
91912D structureCHEMBL1079942C26H36N4O2436.64 / 14.5Yes
5575522D structureCHEMBL208726C24H29N5O403.535 / 14.6Yes
96582D structureCHEMBL468952C27H27Cl2NO452.4192 / 16.9No
103052D structureCHEMBL2204353C21H24ClFN2O2S422.9435 / 13.6Yes
103062D structureCHEMBL2204354C21H24ClFN2O2S422.9435 / 13.6Yes
106752D structureCHEMBL516801C29H31Cl2N3O2524.4864 / 16.2No
111162D structureCHEMBL202604C26H29N3O2415.5373 / 24.4Yes
114642D structureFGGFTCARKCARKC62H102N22O14S21443.7621 / 23-5.7No
116842D structurespiropiperidine analogue, 36C35H42Cl2N4O605.6484 / 18.2No
119112D structure8-(1-Naphthalenylmethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-3-acetic acid Methyl EsterC27H29N3O3443.5475 / 04.5Yes
125932D structureCHEMBL1834415C29H40ClNO4502.0925 / 25.6No
127292D structureCHEMBL181545C27H43N3O4S505.7187 / 04.9No
130842D structureCHEMBL233749C25H26Cl2N2O441.3963 / 24.7Yes
139362D structureCHEMBL3262553C31H36N2O452.6422 / 06.8No
141432D structurearylpyrazole, 22C21H24ClN5381.9084 / 13.8Yes
151882D structureCHEMBL382257C29H40N2O432.6522 / 16.4No
155952D structureCHEMBL419272C25H24BrN3O462.3913 / 15.1No
158862D structurespiropiperidine analogue, 39C33H38Cl2N4O577.5944 / 07.2No
161262D structureCHEMBL379297C24H23N3353.4692 / 14.7Yes
165412D structureCHEMBL395838C24H24FNO361.463 / 14.7Yes
165492D structureCHEMBL513667C29H30Cl2N2O493.4722 / 17.0No
167202D structureCHEMBL2088049C21H23ClN2OS386.9384 / 04.0Yes
167312D structureCHEMBL550117C22H22Cl3N3434.7892 / 15.9No
5219702D structureCHEMBL3808523C77H106N24O131575.8518 / 260.1No
170162D structureCHEMBL512612C28H28Cl2N2O2495.4443 / 16.2No
173242D structureCHEMBL198604C34H49N3O2531.7854 / 16.4No
174532D structureCHEMBL228849C24H24ClNO377.9122 / 15.2No
179042D structureCHEMBL409351C32H40N4O3528.6975 / 05.7No
180482D structureD0C9QVC80H131N27O221823.0927 / 27-10.8No
183822D structureCHEMBL1079561C26H28N4O2428.5363 / 13.6Yes
183892D structureCHEMBL182410C25H32ClN3O3457.9994 / 24.7Yes
193672D structureCHEMBL211846C22H31FN2342.5022 / 16.2No
196592D structureCHEMBL355202C25H25N3O383.4953 / 14.5Yes
196772D structureSCHEMBL8092935C25H25N3O383.4953 / 14.5Yes
196782D structureCHEMBL281274C25H25N3O383.4953 / 14.5Yes
199582D structureCHEMBL2088048C22H28ClNO2S405.9814 / 04.4Yes
201392D structurespiropiperidine analogue, 18C29H29N3O435.5713 / 05.1No
4654182D structureCHEMBL3585387C24H27N3O7469.4949 / 3N/AN/A
207802D structureCHEMBL517733C27H29Cl2N3466.453 / 16.0No
208172D structureCHEMBL337128C24H20N4O4428.4486 / 24.0Yes
214202D structurespiropiperidine analogue, 70C29H39ClN4O495.1084 / 15.6No
219802D structureCHEMBL2387198C23H34N2O354.5382 / 04.7Yes
5221392D structureCHEMBL3775436C15H26ClNO3303.8274 / 3N/AN/A
5222112D structureCHEMBL3775769C15H26ClNO3303.8274 / 3N/AN/A
227242D structureCHEMBL2204347C22H26ClFN2O2S436.975 / 14.0Yes
227252D structureCHEMBL2204348C22H26ClFN2O2S436.975 / 14.0Yes
227262D structureCHEMBL2088058C22H26ClFN2O2S436.975 / 14.0Yes
5481572D structureCHEMBL3955335C27H33FN2O2436.5714 / 15.5No
241802D structureCHEMBL240941C31H44N4O4536.7175 / 15.4No
243832D structureCHEMBL231866C27H29Cl2N3O2498.4483 / 34.8Yes
246522D structureCHEMBL512896C23H30N2O2366.5054 / 22.7Yes
254552D structureCHEMBL460093C28H29Cl2FN2483.4523 / 17.0No
5580622D structureCHEMBL211310C23H26N4O374.4884 / 14.9Yes
263202D structureCHEMBL315551C27H43N3409.6623 / 06.5No
268762D structureCHEMBL467314C28H29Cl2N3O494.462 / 26.3No
270242D structureBDBM50259285C27H26Cl2N2O465.4183 / 06.9No
272142D structureCHEMBL2203713C18H22N4S326.4624 / 22.9Yes
5580902D structureCHEMBL211222C19H26N4O326.4444 / 14.2Yes
272972D structureCHEMBL392798C23H26FN3O379.4794 / 14.0Yes
277182D structureCHEMBL1762405C28H31N5O2469.5896 / 43.0Yes
278482D structureBDBM50121253C80H132N28O211822.1126 / 30-8.1No
4594582D structure[8-(3,3-Diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic AcidC30H33N3O3483.6125 / 12.9Yes
288292D structureCHEMBL233721C21H27NO309.4532 / 14.5Yes
289472D structureCHEMBL200204C25H31N3O2405.5424 / 23.6Yes
289492D structureCHEMBL211373C25H31N3O2405.5424 / 23.6Yes
289522D structureCHEMBL200371C25H31N3O2405.5424 / 23.6Yes
289852D structureCHEMBL378394C23H24ClN3O393.9153 / 15.3No
289992D structureCHEMBL424934C64H103N23O16S21514.7923 / 23-6.9No

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