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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameExtracellular calcium-sensing receptor
SpeciesHomo sapiens (Human)
GeneCASR
SynonymCaS receptor
extracellular calcium-sensing receptor
divalent cation-sensing receptor
PCaR1 {ECO:0000303|PubMed:8698326}
hCasR {ECO:0000303|PubMed:27386547}
[ Show all ]
DiseaseSecondary hyperparathyroidism
Osteoporosis
Myelodysplastic syndrome
Hyperparathyroidism
Cerebrovascular ischaemia
[ Show all ]
Length1078
Amino acid sequenceMAFYSCCWVLLALTWHTSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRKRSSSLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLALTQQEQQQQPLTLPQQQRSQQQPRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQKSSDTLTRHEPLLPLQCGETDLDLTVQETGLQGPVGGDQRPEVEDPEELSPALVVSSSQSFVISGGGSTVTENVVNS
UniProtP41180
Protein Data Bank5fbh, 5k5s, 5k5t, 5fbk
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 5fbh.
BioLiPBL0349605,BL0349608, BL0349604,BL0349607, BL0349606,BL0349609, BL0353425,BL0353426,BL0353427,, BL0353434, BL0349610,BL0349613, BL0349611,BL0349614, BL0349612,BL0349615, BL0353424,BL0353430
Therapeutic Target DatabaseT92076
ChEMBLCHEMBL1878
IUPHAR54
DrugBankBE0000509

Known ligands

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Total entries: 620
Page:  / 7 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
5214382D structureCHEMBL3828329C28H35NO5465.596 / 21.3Yes
1082D structureCHEMBL2377738C36H39N5O2573.7414 / 16.0No
1512D structureCHEMBL2349596C29H32N4O2468.6014 / 14.3Yes
5573282D structureCHEMBL195566C22H23FN2O2366.4364 / 14.5Yes
5573342D structureCHEMBL1689044C33H38N4O506.6943 / 27.2No
19432D structureCHEMBL458516C28H27N5O6529.55310 / 24.0No
32202D structureCHEMBL2346767C23H24N2O2360.4572 / 24.7Yes
40132D structureCHEMBL599039C26H35N3O405.5862 / 06.7No
5574052D structureCHEMBL1688085C26H31FN4O434.5594 / 25.3No
58202D structureCHEMBL1224263C23H25NO2347.4583 / 14.8Yes
5360912D structure(2S)-3-{[(3-chloro-4-methyl-5-sulfophenyl)carbamoyl]amino}-2-(methylamino)propanoic acidC12H16ClN3O6S365.7857 / 5-2.4Yes
5574772D structureCHEMBL1689055C34H40N4O2536.724 / 27.0No
5216602D structureCHEMBL3828187C27H34ClNO6504.027 / 31.4No
77272D structureCHEMBL1224260C22H22FNO335.4223 / 14.9Yes
90232D structureCHEMBL597396C29H28N2O4468.5534 / 14.9Yes
5479942D structureetelcalcetideC38H73N21O10S21048.2617 / 18-10.7No
5575722D structureCHEMBL183287C22H17FN2O2360.3884 / 14.2Yes
109022D structureCHEMBL2349588C29H35N3O3473.6174 / 23.7Yes
121072D structureCHEMBL199548C28H33N3O427.5924 / 24.8Yes
124512D structureCHEMBL2349584C31H37N3O5531.6536 / 23.7No
128662D structureCHEMBL1084201C30H39NO2445.6473 / 26.8No
5576532D structureCHEMBL1689809C25H27F3N4O456.5136 / 25.0Yes
5218702D structureCHEMBL3828182C26H31ClFNO5491.9847 / 31.5Yes
5218712D structureCHEMBL3827356C26H31ClFNO5491.9847 / 31.5Yes
5218722D structureCHEMBL3827154C26H31ClFNO5491.9847 / 31.5Yes
142612D structureCHEMBL1223222C22H28N2O336.4792 / 05.1No
5218852D structureCHEMBL3827410C29H34N2O5490.67 / 31.0Yes
148872D structureCHEMBL2346781C30H35N3O4501.6275 / 14.4No
159742D structureCHEMBL1224190C16H19NO241.3342 / 13.2Yes
5577502D structureCHEMBL1290216C23H28N4O376.5043 / 24.1Yes
170222D structureCHEMBL371936C22H25N3O2363.4614 / 33.3Yes
189172D structureCHEMBL2349603C31H34N4O3510.6385 / 14.6No
5578572D structureCHEMBL1689054C29H38N4O3490.6485 / 25.5No
202282D structureCHEMBL1223299C19H22N2O294.3982 / 04.0Yes
204222D structureCHEMBL2349597C29H32F3N3O2511.5896 / 15.4No
208052D structureCHEMBL490492C28H29N5O5515.579 / 23.5No
210552D structureCHEMBL200248C20H27NO4S377.4995 / 22.7Yes
5365112D structureCHEMBL3980928C10H12ClN3O7S353.738 / 6-3.1No
215092D structureCHEMBL1223370C21H26N2O3354.454 / 04.0Yes
222262D structureCHEMBL454375C27H34N4O5494.5928 / 24.7Yes
5223422D structureCHEMBL3827209C27H35NO5S485.6397 / 31.3Yes
259342D structureCHEMBL570593C27H30N2O4446.5476 / 31.9Yes
5366922D structureCHEMBL3895461C11H14ClN3O5S2367.8197 / 5-2.3Yes
281862D structureCHEMBL200041C26H31N3OS433.6145 / 24.6Yes
289232D structureCHEMBL2346785C32H38N2O3498.6673 / 17.8No
293182D structureCHEMBL598016C27H28N2O2412.5332 / 16.5No
317802D structureCHEMBL2375383C30H32N4O4S544.677 / 22.6No
327362D structureCHEMBL180549C22H17FN2O344.3893 / 04.6Yes
334542D structureCHEMBL372820C27H33N3O3447.5795 / 24.9Yes
5583532D structureCHEMBL371828C20H20N2O2320.3923 / 13.5Yes
353162D structureBDBM50331965C25H30N4O402.5423 / 14.2Yes
360092D structureCHEMBL2377728C26H31N5O2445.5675 / 12.7Yes
376362D structureCHEMBL2346666C24H26N2O358.4851 / 25.0Yes
388212D structureCHEMBL493228C30H32N4O6544.6089 / 24.5No
388782D structureCHEMBL3093424C30H34N6O4S2606.769 / 23.9No
5369922D structureCHEMBL3964061C11H15N3O7S333.3158 / 5-3.9Yes
396342D structureCHEMBL3093418C31H33FN4O2S544.6896 / 16.0No
407422D structureCHEMBL1083307C25H30ClNO2411.973 / 25.4No
413062D structureCHEMBL2349602C32H35N3O3509.654 / 15.3No
421472D structure802916-41-2C30H32N4O5528.6098 / 34.7No
427122D structureCHEMBL2377741C30H34N4O3S530.6876 / 15.3No
431642D structureCHEMBL2349591C29H32F3N3O2S543.6497 / 16.3No
432262D structureCHEMBL1082711C26H33NO2391.5553 / 25.3No
447502D structureCHEMBL523682C30H32N4O6544.6089 / 24.5No
451562D structureCHEMBL1224193C17H21NO2271.363 / 13.1Yes
466572D structureCHEMBL599665C21H22N2O2334.4192 / 04.5Yes
473172D structureCHEMBL1256301C15H12ClNOS289.7773 / 14.0Yes
5587772D structureCHEMBL1689812C31H39F3N4O540.6756 / 27.8No
511402D structureCHEMBL1222489C29H31F3N2O3512.5737 / 06.8No
515912D structureCHEMBL488337C20H27NO3329.444 / 23.4Yes
5588752D structureCHEMBL369998C22H24N2O2348.4463 / 13.8Yes
5588812D structureCHEMBL1289679C24H26ClF3N4O478.9446 / 25.9No
5589042D structureCHEMBL1689811C29H35F3N4O512.6216 / 26.7No
531632D structureCHEMBL3093422C31H34ClN5O4S2640.2148 / 25.1No
532262D structureCHEMBL2346783C31H30N2O3478.5923 / 16.2No
542452D structureCHEMBL599040C23H27N3O361.4892 / 15.4No
543842D structureCHEMBL2349587C30H35N3O3485.6284 / 14.2Yes
559362D structureCHEMBL1083308C25H30ClNO2411.973 / 25.4No
564502D structureCHEMBL569863C21H22F3N3O389.4226 / 14.8Yes
5232482D structureCHEMBL3827898C28H35NO7S529.6488 / 30.0No
588092D structureCHEMBL3093425C31H32ClF2N5O4S2676.19510 / 25.3No
5232642D structureCHEMBL3827577C27H35NO5S485.6397 / 31.4Yes
622842D structureCHEMBL1801171C21H23ClN2O3S418.9365 / 3N/AN/A
637332D structureCHEMBL1083314C25H30N2O4422.5255 / 24.6Yes
640802D structureCHEMBL1084514C28H36N2O4464.6066 / 24.2Yes
648962D structureCHEMBL1222492C28H31BrN2O3S555.5315 / 05.7No
656762D structureCHEMBL455406C30H32N4O4512.617 / 15.3No
5375722D structureCHEMBL3949209C15H20ClN3O7S421.8498 / 4-3.1Yes
659732D structureCHEMBL1224343C24H24F3NO399.4575 / 16.0No
5594282D structureCHEMBL1688102C27H23F3N4O476.5036 / 25.8No
686502D structureCHEMBL1256403C16H14ClNOS303.8043 / 14.4Yes
688422D structureCHEMBL2377749C30H34N4O2S514.6885 / 15.7No
5376682D structureCHEMBL3946636C11H12N4O7312.2388 / 5-3.3Yes
704232D structureCHEMBL487508C20H25Cl2NO3398.3244 / 24.6Yes
704262D structureCHEMBL487507C20H25Cl2NO3398.3244 / 24.6Yes
704282D structureCHEMBL491251C20H25Cl2NO3398.3244 / 24.6Yes
708362D structureCHEMBL2349582C35H45N3O4571.7625 / 16.6No
710392D structureCHEMBL3093421C32H36ClN5O4S2654.2418 / 25.5No
722862D structureCHEMBL1224344C23H21ClF3NO419.8725 / 16.3No
723062D structureCHEMBL2349586C31H37N3O3499.6554 / 14.7Yes

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