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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameMetabotropic glutamate receptor 5
SpeciesHomo sapiens (Human)
GeneGRM5
SynonymmGlu5 receptor
glutamate receptor
GPRC1E
mGluR5
DiseaseCentral nervous system disease
Chronic neuropathic pain
Fragile X syndrome
Major depressive disorder; GERD; Chronic neuropathic pain
Autism
[ Show all ]
Length1212
Amino acid sequenceMVLLLILSVLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTLKTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMDDDEVWSKKSNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIREVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTSTVVRMHVGDGKSSSAASRSSSLVNLWKRRGSSGETLRYKDRRLAQHKSEIECFTPKGSMGNGGRATMSSSNGKSVTWAQNEKSSRGQHLWQRLSIHINKKENPNQTAVIKPFPKSTESRGLGAGAGAGGSAGGVGATGGAGCAGAGPGGPESPDAGPKALYDVAEAEEHFPAPARPRSPSPISTLSHRAGSASRTDDDVPSLHSEPVARSSSSQGSLMEQISSVVTRFTANISELNSMMLSTAAPSPGVGAPLCSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQPAAGAQAAGDAARESPAAGPEAAAAKPDLEELVALTPPSPFRDSVDSGSTTPNSPVSESALCIPSSPKYDTLIIRDYTQSSSSL
UniProtP41594
Protein Data Bank4oo9, 5cgc, 5cgd, 6ffh, 6ffi, 6n4x, 6n4y, 6n50, 6n51, 3lmk
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 4oo9.
BioLiPBL0176927,BL0176931, BL0176928,BL0176929,BL0176930, BL0281199, BL0322076, BL0322077, BL0407724, BL0438693, BL0438694, BL0438695,BL0438696,BL0438697, BL0407725, BL0438698,BL0438699
Therapeutic Target DatabaseT99347
ChEMBLCHEMBL3227
IUPHAR293
DrugBankBE0001192

Known ligands

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Total entries: 3156
Page:  / 32 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
5214492D structureCHEMBL3739885C9H5BrClN3OS318.5734 / 13.4Yes
6482D structureCHEMBL215957C18H19NO265.3562 / 04.3Yes
4592402D structureCHEMBL3655617C17H11N5O2317.3086 / 11.5Yes
9052D structureCHEMBL2151617C18H18F3N3O2365.3567 / 03.1Yes
10862D structureCHEMBL246041C15H12N2O3268.2723 / 22.3Yes
5214732D structureCHEMBL3742147C10H5ClN4OS264.6875 / 12.4Yes
5359452D structureCHEMBL3982481C19H18FN3O323.3714 / 02.2Yes
12072D structureSCHEMBL6918188C17H13ClN4O3356.7666 / 12.8Yes
12192D structureCHEMBL184047C17H11FN6S350.3757 / 03.5Yes
15382D structureBDBM50201676C11H13N5O2247.2584 / 30.2Yes
5215012D structureCHEMBL3736163C18H22N6O338.4156 / 02.3Yes
21012D structureCHEMBL2346732C18H14F4N4O378.3317 / 13.9Yes
21952D structureCHEMBL1784103C17H14ClFN2O3348.7586 / 13.9Yes
29312D structureCHEMBL224615C17H14N4OS322.3865 / 03.2Yes
4418562D structureCHEMBL3410212C17H11N3O273.2953 / 02.2Yes
5360222D structureSCHEMBL2520315C19H18ClN3O339.8232 / 03.6Yes
40332D structureAcamprosateC5H11NO4S181.2064 / 2-1.2Yes
42452D structureCHEMBL1783868C20H18N4OS362.4515 / 14.7Yes
44042D structureCHEMBL2403653C18H19N3O2S2373.4896 / 02.6Yes
51502D structureCHEMBL2403667C18H16N2OS308.3993 / 03.7Yes
53022D structureCHEMBL595943C17H18ClN3O315.8013 / 13.7Yes
58102D structureCHEMBL1808881C21H23ClN2O354.8782 / 04.3Yes
4592772D structureCHEMBL3655594C18H13N5O2331.3356 / 11.9Yes
63452D structureCHEMBL185813C13H11NS213.2982 / 03.8Yes
4419592D structureCHEMBL334842C6H9N3O3S203.2166 / 3-3.4Yes
4419612D structureCHEMBL131922C6H9N3O3S203.2166 / 3-3.4Yes
67512D structureCHEMBL2113099C21H16N2O2328.3713 / 02.9Yes
68152D structureCHEMBL1779857C15H12N2OS268.3343 / 02.2Yes
5361112D structureCHEMBL3939809C20H18F2N2O340.3744 / 03.3Yes
5361122D structureSCHEMBL2518446C19H18N2O2306.3653 / 12.9Yes
70262D structureCHEMBL181424C13H14N4O242.2824 / 22.0Yes
5361412D structureCHEMBL3899832C22H19N5O4417.4258 / 23.6Yes
72032D structureCHEMBL238262C17H11N5OS333.3695 / 13.1Yes
5361612D structureSCHEMBL2520891C18H17N3O291.3543 / 02.4Yes
74292D structure3-methyl-N-(6-methylpyridin-2-yl)benzamideC14H14N2O226.2792 / 12.8Yes
77912D structureCHEMBL224322C21H24N4OS380.515 / 04.3Yes
78172D structureCHEMBL594296C18H19Cl2N3O364.273 / 14.7Yes
78362D structureCHEMBL2426602C19H22N2O3S358.4565 / 02.9Yes
5361732D structureSCHEMBL2959176C19H18N6O3378.3927 / 11.2Yes
78802D structureQuinoline,2-[2-(5-fluoro-2-pyrimidinyl)ethynyl]-C15H8FN3249.2484 / 02.7Yes
79952D structureCHEMBL386408C17H21N5O2S359.4486 / 02.3Yes
80442D structureCHEMBL239604C13H9ClN4O272.6923 / 22.5Yes
81502D structureCHEMBL2338601C20H22ClN3O2371.8653 / 23.8Yes
82622D structureCHEMBL2208408C15H15ClN2O3S338.8064 / 12.6Yes
82852D structureCHEMBL2151622C18H21ClN4O2360.8424 / 03.1Yes
85672D structureCHEMBL3122214C18H14F2N6O2384.3479 / 02.2Yes
85682D structure42160-26-9C12H10N2S214.2863 / 13.6Yes
5361912D structureSCHEMBL9926343C21H20FN3O2365.4084 / 02.9Yes
86942D structureCHEMBL607689C20H22FN3323.4153 / 03.6Yes
4639322D structureCHEMBL3605277C20H16F2N2O3370.3566 / 03.1Yes
87352D structureCHEMBL1684105C21H19NO301.3891 / 04.2Yes
87462D structureCHEMBL1771682C19H22FN3O2343.4025 / 03.7Yes
88232D structureCHEMBL2153782C15H14N4O266.3043 / 22.2Yes
4639762D structureCHEMBL3603928C15H9N5259.2725 / 01.6Yes
4640072D structureCHEMBL3605300C22H21FN2O3380.4195 / 03.9Yes
93432D structureCHEMBL207097C18H17ClN4O340.8115 / 03.6Yes
96212D structureCHEMBL1771692C20H16F3N3O2387.3627 / 04.0Yes
5479952D structureCHEMBL3903257C22H21FN2O348.4213 / 03.9Yes
5362392D structureCHEMBL3924488C22H21FN2O348.4213 / 03.9Yes
99532D structureCHEMBL363408C31H33NO5499.6075 / 06.3No
99712D structureCHEMBL575695C21H19NO3S365.4474 / 15.6No
101962D structure2-acetamido-N-(3-chlorophenyl)benzamideC15H13ClN2O2288.7312 / 23.8Yes
102082D structureBDBM50179661C15H18N4O2286.3353 / 32.0Yes
104012D structureCHEMBL2426616C14H14N2O2S274.3384 / 02.3Yes
106102D structureAC1LSLDPC14H14N4O2S302.3525 / 12.8Yes
106112D structureGSK2210875C14H14N4O2S302.3525 / 12.8Yes
106132D structure1-(6-methyl[1,3]thiazolo[3,2-b][1,2,4]triazol-5-yl)ethyl N-phenylcarbamateC14H14N4O2S302.3525 / 12.8Yes
5362632D structureSCHEMBL9926434C22H19FN4O2390.4185 / 02.7Yes
108172D structureCHEMBL1783862C19H15FN4O2S382.4137 / 13.8Yes
110222D structureCID 53321026C16H10O2234.2542 / 03.5Yes
4642662D structureCHEMBL3633967C14H16N4O2272.3084 / 00.4Yes
116892D structureSCHEMBL8030897C13H12N4O2S288.3255 / 12.4Yes
4421612D structureCHEMBL3398289C19H17N3O3335.3635 / 02.3Yes
5363092D structureSCHEMBL2959089C18H15ClN6O3398.8077 / 11.7Yes
122562D structureCHEMBL1290788C18H21N3O2311.3854 / 01.6Yes
125512D structureCHEMBL610918C18H20ClN3O329.8283 / 14.1Yes
4643882D structureCHEMBL3633978C21H21N3O2347.4183 / 03.0Yes
129062D structureVU 0361737C13H11ClN2O2262.6933 / 12.6Yes
130072D structureBDBM50201658C9H9ClN4O2S272.7074 / 31.5Yes
130152D structureCHEMBL2349537C18H16F2N4O342.355 / 13.3Yes
130822D structureCHEMBL3122219C20H18N6O358.4056 / 02.0Yes
133232D structureQUISQUALIC ACIDC5H7N3O5189.1276 / 3-3.9Yes
133312D structure2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acidC5H7N3O5189.1276 / 3-3.9Yes
134232D structureCHEMBL568515C15H17NO2S275.3664 / 14.6Yes
134602D structureCHEMBL215746C15H12N2O236.2742 / 12.7Yes
135572D structureCHEMBL1289784C19H22Cl2N2O365.2983 / 04.5Yes
135712D structureCHEMBL511355C18H22N4O2326.44 / 02.4Yes
137912D structureCHEMBL407707C18H14F3N3O2S393.3847 / 13.7Yes
138792D structureCHEMBL363062C22H16ClN3O373.842 / 15.3No
141962D structureCHEMBL235975C18H14N4O2S350.3966 / 13.2Yes
143952D structureCHEMBL1630064C14H13FN4O3304.2816 / 12.2Yes
148902D structureCHEMBL362217C16H11N3S277.3454 / 03.0Yes
149132D structureCHEMBL1771621C19H23N3O2325.4124 / 03.2Yes
149142D structureCHEMBL1771622C19H23N3O2325.4124 / 03.2Yes
5555412D structure2Me4CPGC10H11NO4209.2015 / 3-1.8Yes
150552D structureCHEMBL1257504C19H16N4O316.3645 / 02.8Yes
152162D structureCHEMBL2334981C24H26ClN5OS468.0165 / 2N/AN/A
153162D structureCHEMBL1779862C19H17ClN2O324.8082 / 03.9Yes
153492D structureCHEMBL388087C18H16N4OS336.4135 / 03.1Yes
4422532D structureCHEMBL3422865C22H21N5O2S419.5035 / 23.9Yes

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