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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameProstaglandin E2 receptor EP4 subtype
SpeciesRattus norvegicus (Rat)
GenePtger4
SynonymEP2
EP4 receptor
PGE receptor EP4 subtype
PGE2 receptor EP4 subtype
Prostanoid EP4 receptor
DiseaseN/A for non-human GPCRs
Length488
Amino acid sequenceMSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMLRQFMRRTSLGTEQHHAAAAAAVASVACRGHAAASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPSVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDGSAQHCSESRRTSSAMSGHSRSFLSRELREISSTSHTLLYLPDLTESSLGGKNLLPGTHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSQREEPASKGNSLQVTFPSETLKLSEKCI
UniProtP43114
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4086
IUPHAR343
DrugBankN/A

Known ligands

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Total entries: 131
Page:  / 2 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
30242D structureCHEMBL1929538C21H29NO6S423.5247 / 21.7Yes
30492D structureCHEMBL3115074C23H28N2O4396.4875 / 21.3Yes
78142D structureCHEMBL1929550C23H33NO4S419.585 / 22.8Yes
114262D structureCHEMBL383515C24H28ClNO4429.9414 / 24.4Yes
131452D structureCHEMBL1929526C23H33NO5403.5195 / 22.2Yes
182412D structureCHEMBL551951C17H35NO5S365.5296 / 23.1Yes
194972D structureCHEMBL2037291C29H29N3O5S2563.6879 / 25.1No
200262D structureCHEMBL382197C28H31NO4S477.6195 / 25.4No
230322D structureCHEMBL46395C22H30F3NO4429.487 / 23.9Yes
5533712D structureprostaglandin D2C20H32O5352.4715 / 32.6Yes
347722D structureCHEMBL553468C19H31NO4S369.525 / 13.8Yes
5534332D structureCR6086C26H27F3N2O3472.5087 / 22.6Yes
401982D structureCHEMBL1929527C22H31NO5S421.5526 / 21.6Yes
427822D structureCHEMBL208080C24H28FNO4413.4895 / 23.8Yes
460862D structureCHEMBL1929545C21H29NO3S375.5274 / 23.1Yes
465212D structureCHEMBL2036325C27H24ClN3O4S3586.1369 / 25.6No
489342D structureCHEMBL206774C27H35NO5453.5795 / 24.5Yes
490352D structureCHEMBL1929539C19H25NO4S2395.5326 / 22.6Yes
5534792D structure11-deoxy-PGE2C20H32O4336.4724 / 23.8Yes
558282D structureCHEMBL1929528C23H32O5S420.5646 / 22.5Yes
558442D structureCHEMBL558671C21H27NO4S389.515 / 13.7Yes
663982D structureCHEMBL427035C24H29NO4395.4994 / 23.7Yes
706642D structureCHEMBL2036319C27H28N2O5S2524.658 / 24.5No
745482D structureCHEMBL208411C30H33NO4471.5974 / 25.4No
759782D structureCHEMBL559955C21H27NO4S389.515 / 14.2Yes
819622D structureCHEMBL3115074C23H29ClN2O4432.9455 / 3N/AN/A
850212D structureUNII-V02XH3498ZC36H32N2O4S588.7225 / 17.5No
910212D structureCHEMBL1957436C26H25ClN2O4S2529.0667 / 25.1No
975532D structureCHEMBL2037292C27H24ClN3O5S2570.0759 / 25.0No
5537502D structurealprostadilC20H34O5354.4875 / 33.2Yes
1096042D structureCHEMBL425409C22H30N2O4386.4925 / 22.7Yes
1142852D structureCHEMBL425950C24H31NO4S429.5755 / 24.6Yes
1209432D structureCHEMBL559820C22H29NO4S403.5375 / 14.6Yes
1246112D structureCHEMBL2036314C28H31NO5S493.6186 / 24.0Yes
1282142D structureCHEMBL554823C20H33NO5S399.5466 / 23.1Yes
1343502D structureCHEMBL203076C21H31NO5377.4815 / 32.7Yes
1361122D structureCHEMBL1929542C20H24F3NO4S2463.539 / 23.5Yes
5539782D structureAH23848C29H35NO5477.6016 / 11.6Yes
5539802D structureAH 23848C29H35NO5477.6016 / 11.6Yes
1400112D structureCHEMBL1929531C21H29NO5S407.5256 / 22.9Yes
1433502D structureCHEMBL207237C22H26FNO4S419.5116 / 23.9Yes
1474702D structureCHEMBL2036326C28H27N3O5S2549.669 / 24.7No
1481302D structureCHEMBL222715C21H29NO4359.4664 / 23.3Yes
1587252D structureCHEMBL2036315C26H32N2O5S484.6117 / 22.3Yes
1589092D structureCHEMBL1929533C20H24F3NO5S447.4699 / 22.9Yes
1601142D structureCHEMBL2037289C28H27N3O5S2549.669 / 24.7No
5541052D structureEP4AC32H29F3N4O4S2654.7239 / 17.3No
1635222D structureUNII-XO355X0D3BC23H26F3NO4S469.5198 / 24.7Yes
1635672D structureCHEMBL2036312C27H30N2O5S494.6067 / 23.4Yes
1711072D structureCHEMBL2036307C26H31NO4S453.5975 / 23.6Yes
1720142D structureCHEMBL549869C21H27NO5S405.5096 / 13.5Yes
1749472D structureCHEMBL2036309C25H30N2O4S454.5856 / 22.5Yes
1830082D structureCHEMBL1933717C21H29NO4S391.5265 / 22.3Yes
1833222D structureCHEMBL2037290C28H27N3O5S2549.669 / 24.7No
1849402D structureCHEMBL223151C18H31NO4S357.5095 / 22.3Yes
1854142D structureCHEMBL559561C18H29NO5S371.4926 / 13.0Yes
1877922D structureCHEMBL2036324C27H25N3O4S3551.6949 / 25.0No
1909622D structureCHEMBL549461C19H31NO4S369.525 / 14.0Yes
1914162D structureCHEMBL559760C22H29NO4S403.5375 / 14.6Yes
5542622D structureU 46619C21H34O4350.4994 / 23.9Yes
1987762D structureCHEMBL1929530C20H27NO5S393.4986 / 22.4Yes
2017582D structureCHEMBL2036313C27H30N2O4S2510.6677 / 24.1No
2033782D structureCHEMBL425243C22H26ClNO4S435.9635 / 24.4Yes
2043582D structureCHEMBL192729C28H33N3O7523.5867 / 43.8No
2073272D structureCHEMBL1929537C20H24F3NO6S463.46810 / 23.2Yes
2149462D structureCHEMBL1929544C21H29NO5S2439.5857 / 22.2Yes
2151572D structureCHEMBL1929547C24H35NO3S417.6084 / 24.5Yes
2173672D structureCHEMBL1929540C21H29NO4S2423.5866 / 23.4Yes
2209522D structureCHEMBL1929529C19H25NO5S379.4716 / 22.1Yes
2214872D structureCHEMBL379746C22H26ClNO4S435.9635 / 24.4Yes
2228802D structureCHEMBL204058C21H30ClNO4395.9244 / 23.6Yes
2271812D structureCHEMBL562291C21H33NO5S411.5576 / 13.7Yes
2327612D structureCHEMBL2036311C28H32N2O4S492.6345 / 33.7Yes
5544402D structureDpt-prostaglandin E1C22H30O5374.4775 / 23.5Yes
2361832D structureCHEMBL2036320C28H30N2O4S2522.6787 / 25.2No
2488202D structureCHEMBL292964C23H32O6S436.5637 / 31.5Yes
5545432D structurebutaprost acidC23H38O5394.5525 / 33.9Yes
2575972D structureCHEMBL562411C21H35NO5S413.5736 / 23.6Yes
2600022D structureCHEMBL1929532C22H31NO5S421.5526 / 23.4Yes
2610992D structureCHEMBL2036318C27H28N2O4S2508.6517 / 24.9No
2616282D structureCHEMBL379785C28H31NO4S477.6195 / 25.4No
2622052D structureCHEMBL1957437C30H28N2O4S2544.6847 / 25.7No
2638182D structureCHEMBL2036323C27H25N3O5S2535.6339 / 24.4No
2703442D structureCHEMBL2036322C28H26N2O5S2534.6458 / 24.9No
5546262D structuredinoprostC20H34O5354.4875 / 42.7Yes
2744392D structureCHEMBL2036321C28H30N2O4S2522.6787 / 25.2No
2801522D structureMK-2894C25H22F3NO3S473.517 / 25.9No
2848872D structureCHEMBL556333C22H29NO4S403.5375 / 13.9Yes
2853432D structureCHEMBL205819C23H35NO5405.5355 / 22.7Yes
2853892D structureCHEMBL1929541C22H31NO4S2437.6136 / 23.9Yes
2881012D structureCHEMBL1929543C19H24FNO4S2413.5227 / 22.7Yes
3002302D structureCHEMBL378968C22H26FNO4S419.5116 / 23.9Yes
3053122D structureCHEMBL2036317C26H32N2O5S484.6117 / 22.3Yes
3101342D structureCHEMBL541516C26H30N2O4S466.5966 / 14.8Yes
3110532D structureCHEMBL562825C22H29NO5S419.5366 / 14.4Yes
3114392D structureCHEMBL381755C30H33NO5487.5965 / 25.3No
3142262D structureCHEMBL383339C24H37NO5419.5625 / 23.1Yes
3161402D structureCHEMBL1929551C21H29NO3S2407.5875 / 22.9Yes
3175252D structureCHEMBL1929548C22H28F3NO3S443.5257 / 24.0Yes
3200872D structureCHEMBL1933722C21H24N2O4S2432.5537 / 23.2Yes

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