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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameProstaglandin E2 receptor EP2 subtype
SpeciesHomo sapiens (Human)
GenePTGER2
SynonymEP2 receptor
Ptger-ep2
prostaglandin E receptor 2 (subtype EP2), 53kDa
Prostanoid EP2 receptor
PGE2 receptor EP2 subtype
[ Show all ]
DiseaseMiscarriage
Pulmonary arterial hypertension
Osteoporosis
Medical abortion
Immune disorder
[ Show all ]
Length358
Amino acid sequenceMGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
UniProtP43116
Protein Data BankN/A
GPCR-HGmod modelP43116
3D structure modelThis predicted structure model is from GPCR-EXP P43116.
BioLiPN/A
Therapeutic Target DatabaseT38529
ChEMBLCHEMBL1881
IUPHAR341
DrugBankBE0000368

Known ligands

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Total entries: 1001
Page:  / 11 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
5554792D structureSCHEMBL17472597C27H27N3O5S2537.6499 / 24.9No
4302D structureCHEMBL2164612C40H43BF4N2O4702.59810 / 1N/ANo
8522D structureCHEMBL180742C26H22Cl2O4469.3584 / 26.4No
5359332D structureCHEMBL3904946C24H25FO4396.4585 / 23.9Yes
15952D structureCHEMBL207203C23H24ClNO5S461.9575 / 23.0Yes
16302D structureCHEMBL3264203C22H23FN2O350.4372 / 14.6Yes
18212D structureCHEMBL314533C38H34N2O4S614.764 / 17.6No
30512D structureCHEMBL3115074C23H28N2O4396.4875 / 21.3Yes
34242D structureCHEMBL3264220C23H28N2O4396.4874 / 13.5Yes
5173352D structureCHEMBL3955120C24H24FNO3393.4585 / 25.8No
5360472D structureSCHEMBL2012413C24H36O4388.5484 / 25.1No
45472D structureCHEMBL430124C20H27NO4S377.4995 / 22.4Yes
5215982D structureCHEMBL3793009C20H22ClNO6407.8477 / 23.2Yes
5173442D structureCHEMBL3893847C28H35F2NO4S519.6487 / 26.8No
5173462D structureCHEMBL3968443C28H35F2NO4S519.6487 / 26.8No
5360852D structureCHEMBL354419C20H18N6O2374.4047 / 11.8Yes
66582D structureCHEMBL313266C27H27NO4S4557.7567 / 16.5No
5173562D structureCHEMBL1202209C21H25FN2324.4433 / 04.5Yes
71832D structureCHEMBL3286709C24H30N4O390.5313 / 13.0Yes
5216612D structureCHEMBL3806076C19H20FNO5S393.4298 / 22.9Yes
5173622D structureCHEMBL3971730C21H15F4NO4421.3489 / 34.6Yes
84482D structureCHEMBL417171C21H26F3NO4413.4377 / 23.1Yes
5362122D structureSCHEMBL5208850C21H29ClO3364.913 / 25.1No
91992D structureCHEMBL123844C27H22O3394.473 / 15.3No
5362242D structureSCHEMBL5205658C27H39ClO4463.0554 / 25.5No
103462D structureCID 52944193C52H48O6768.956 / 2N/ANo
4642332D structureCHEMBL3586319C26H25NO3S431.555 / 05.6No
116352D structureAH 6809C17H14O5298.2945 / 13.9Yes
123692D structureBDBM50370468C25H22O4386.4474 / 25.5No
127772D structureCID 53394056C22H30O5374.4775 / 32.1Yes
131372D structureCHEMBL275245C23H33NO5403.5195 / 22.2Yes
134182D structureCHEMBL3286714C19H17FN4O336.373 / 23.3Yes
135652D structureCHEMBL125110C26H22O3S414.5194 / 16.1No
4645492D structureCHEMBL3586353C23H19ClN2OS406.9284 / 05.2No
138972D structureCHEMBL181035C24H20O3356.4213 / 15.6No
5555402D structureSCHEMBL17472643C29H28N4O4S528.6278 / 24.9No
143422D structureCHEMBL251294C20H27NO4345.4394 / 22.8Yes
143592D structureCHEMBL3264208C22H24N2O3364.4453 / 24.1Yes
4422462D structure[(5Z,8R,9S,11R,12R,13E,15S)-9,11,15-Trihydroxy-1-norprosta-5,13-diene-2-yl]phosphinic acidC19H35O5P374.4585 / 41.9Yes
153042D structureCHEMBL180089C26H23FO3402.4654 / 16.4No
163332D structureCHEMBL90491C37H32N2O4S600.7334 / 17.3No
170502D structureCHEMBL87797C28H28N2O5S2536.6616 / 26.0No
179392D structureCHEMBL3286635C22H27N3O349.4782 / 14.2Yes
182012D structureCHEMBL251710C20H25NO3327.4243 / 13.9Yes
186312D structureCHEMBL3286645C19H19N3O2321.382 / 22.2Yes
5364532D structureSCHEMBL1310801C21H25NO5371.4335 / 13.4Yes
5578872D structureSCHEMBL18357252C30H29ClFNO4522.0135 / 25.7No
5364832D structureSCHEMBL2011904C24H34O4386.5324 / 24.4Yes
5365382D structureSCHEMBL5203473C24H37ClO4425.0064 / 25.4No
221492D structureDG-041C23H15Cl4FN2O3S2592.3025 / 17.8No
5221302D structureCHEMBL3775436C15H26ClNO3303.8274 / 3N/AN/A
5221752D structureCHEMBL3775769C15H26ClNO3303.8274 / 3N/AN/A
5365482D structureCHEMBL3896035C27H36F4N4O5S604.66211 / 25.6No
228052D structureCHEMBL601299C20H14Cl3NO3S454.7464 / 26.4No
230182D structureCHEMBL3286673C20H23N3O321.4242 / 22.6Yes
230332D structureCHEMBL46395C22H30F3NO4429.487 / 23.9Yes
4594212D structureSCHEMBL2194130C24H32O5400.5155 / 33.0Yes
5533762D structureprostaglandin D2C20H32O5352.4715 / 32.6Yes
5174542D structureCHEMBL1202203C19H23N3293.4143 / 02.9Yes
5555742D structureSCHEMBL17472566C28H28N4O5S532.6159 / 24.2No
4659942D structureCHEMBL3586309C24H22N2O2S402.5125 / 04.5Yes
5366452D structureSCHEMBL671511C29H38F4N4O5S630.711 / 26.2No
5366602D structureSCHEMBL2014800C25H32O4S428.5875 / 25.5No
5366722D structureSCHEMBL1309617C21H25NO4S387.4945 / 14.0Yes
266612D structureCHEMBL3286718C23H25N3O2375.4723 / 23.5Yes
266722D structureMLS000553986C22H17ClFN5O5S3582.03611 / 35.3No
5366852D structureSCHEMBL2010315C24H36O4388.5484 / 25.1No
4662382D structureCHEMBL3586326C24H22N2O2S402.5125 / 04.6Yes
275632D structureCID 52945421C50H44O6740.8966 / 2N/ANo
4662812D structureCHEMBL3586333C22H21ClN2O2380.8724 / 04.2Yes
5174602D structureCHEMBL3910551C22H15F3N2O3412.3688 / 24.6Yes
282712D structureCHEMBL3286669C18H19N3O3S357.4284 / 21.9Yes
5174672D structureCHEMBL3903635C23H22FNO4395.436 / 35.1No
286892D structureCHEMBL45008C22H28F3NO4427.4647 / 23.4Yes
5224242D structureCHEMBL3793911C23H28N2O4396.4875 / 11.1Yes
5224302D structureCHEMBL3794185C21H23ClO5S422.926 / 24.4Yes
310072D structureCHEMBL208260C21H18ClF2NO2389.8274 / 14.9Yes
325432D structureCHEMBL223744C22H31NO4373.4934 / 23.8Yes
335582D structureCHEMBL3264209C23H24F2N2O4430.4526 / 24.2Yes
342372D structureCHEMBL3286655C23H27FN4O394.4944 / 13.3Yes
5225672D structureCHEMBL3794585C20H22ClNO6S439.9078 / 23.4Yes
343762D structureCHEMBL434247C29H26O3422.5243 / 17.0No
348272D structureUNII-86KF5VSV88C27H21F3N2O3478.4716 / 25.1No
382732D structureCHEMBL428524C19H35NO4341.4924 / 23.4Yes
382792D structureCHEMBL14286C19H35NO4341.4924 / 23.4Yes
382892D structure64054-40-6C19H35NO4341.4924 / 23.4Yes
384542D structureCHEMBL314200C30H31NO5S2549.76 / 17.1No
385922D structureCHEMBL425681C22H34O6394.5086 / 43.2Yes
391022D structureCHEMBL197319C26H25NO5431.4885 / 15.4No
5370282D structureSCHEMBL5208834C22H31ClO4394.9364 / 34.0Yes
412482D structureCHEMBL258332C23H24ClNO4413.8984 / 23.5Yes
413472D structureindomethacinC19H16ClNO4357.794 / 14.3Yes
418212D structureCHEMBL3260419C19H16O4308.3334 / 14.3Yes
418812D structureCHEMBL173299C22H34O5S410.5696 / 43.8Yes
5585452D structureSCHEMBL18357227C28H28ClNO4S510.0455 / 25.4No
5585572D structureSCHEMBL16092614C25H37NO4415.5744 / 24.2Yes
445142D structureCHEMBL599051C21H18ClNO3S399.8894 / 24.9Yes
5175302D structureCHEMBL3964577C23H21F2NO3397.4226 / 25.5No
455602D structureCHEMBL3286703C23H27N3O361.4892 / 24.7Yes
462152D structureSCHEMBL1566198C23H18FN3O4419.4125 / 43.1Yes

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