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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameGlucagon receptor
SpeciesHomo sapiens (Human)
GeneGCGR
SynonymGL-R
GGR
GR
glucagon receptor
DiseaseDiabetes
Type 2 diabetes
Non-insulin dependent diabetes
Obesity; Diabetes
Type 1 diabetes
[ Show all ]
Length477
Amino acid sequenceMPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProtP47871
Protein Data Bank5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod modelP47871
3D structure modelThis structure is from PDB ID 5yqz.
BioLiPBL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target DatabaseT60182, T87875
ChEMBLCHEMBL1985
IUPHAR251
DrugBankN/A

Known ligands

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Total entries: 979
Page:  / 10 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
4592372D structureCHEMBL3680825C29H22Cl2F3N3O3588.4088 / 36.8No
17042D structureCHEMBL157064C19H15ClN2O3354.794 / 24.3Yes
19592D structureCHEMBL159093C24H20ClF3N2O6524.87710 / 25.7No
34212D structureCHEMBL347544C15H13ClN2O2S320.7914 / 33.4Yes
5573832D structureCID 135462249C15H12ClN3O2S333.795 / 34.3Yes
38252D structureCHEMBL1933352C24H27N3O4421.4975 / 23.8Yes
39542D structureCHEMBL266715C30H37F3N4O6606.6439 / 34.0No
4592692D structureCHEMBL3675905C29H22Cl2F3N3O4604.4079 / 37.1No
61152D structure124864-27-3C20H26FNO2331.4314 / 13.7Yes
68092D structureCHEMBL442855C29H22Cl2N8O2585.4497 / 36.9No
74962D structureCHEMBL447742C34H41N3O5571.7185 / 46.6No
4592922D structureCHEMBL3675870C29H22ClF4N3O3571.9579 / 36.3No
85432D structureCHEMBL383350C29H32F3N7O4599.61510 / 25.2No
89522D structureCHEMBL3656282C30H37Cl2N7O2598.5736 / 26.5No
96942D structureCHEMBL504245C32H31F3N4O5608.6189 / 45.5No
97252D structureCHEMBL2381832C25H26F3N3O4489.4958 / 24.7Yes
110862D structureCHEMBL315836C21H15ClFN3363.823 / 15.1No
112832D structureCHEMBL359176C16H14N2O4S330.3586 / 33.0Yes
113632D structureCHEMBL1643957C25H24F3N7O2511.5099 / 25.5No
5576332D structureSCHEMBL1356029C34H33ClFN3O3S618.1646 / 28.0No
5480232D structureCHEMBL3944843C34H33ClFN3O3S618.1646 / 28.0No
131242D structureCHEMBL435445C26H27ClN2O3450.9634 / 26.4No
133422D structureCHEMBL1922916C34H37ClN2O4573.134 / 28.1No
137382D structureCHEMBL1922697C25H19Cl2F3N8O2591.3769 / 25.8No
137892D structureCHEMBL1644176C25H24F3N7O2511.5099 / 25.9No
4645632D structureCHEMBL3616700C35H32F3N3O4615.6538 / 27.4No
143362D structureCHEMBL439915C25H36N2O2396.5753 / 25.5No
145722D structureCHEMBL64955C30H34N2O5502.6115 / 44.2No
148182D structureCHEMBL278361C23H32ClNO373.9652 / 17.0No
151732D structureCHEMBL198231C32H40F3N3O5603.6838 / 16.3No
160412D structureCHEMBL85009C20H13Cl2N3366.2452 / 15.2No
4650482D structureCHEMBL3616679C32H27F3N4O5604.58610 / 26.0No
178422D structureCHEMBL2159334C28H22Cl2F3N3O4592.3968 / 26.8No
179592D structureCHEMBL1933356C23H24ClN3O4441.9125 / 24.0Yes
179912D structureCHEMBL416169C20H14FN3315.3513 / 14.1Yes
5220302D structureCHEMBL3800146C26H21Cl2N3O3S526.4325 / 25.3No
194362D structureCHEMBL371235C30H36F3N7O3599.6599 / 25.5No
4593902D structureCHEMBL3675813C29H25Cl2N3O3534.4375 / 26.1No
200212D structureCHEMBL219968C30H32N4O6544.6086 / 35.3No
200972D structureCHEMBL147177C17H16N2O3S328.3865 / 13.7Yes
206132D structureCHEMBL106577C23H21N3O3387.4394 / 24.2Yes
209682D structureCHEMBL219308C26H32F3N3O5523.5538 / 35.3No
4594062D structureCHEMBL3675818C29H22ClF4N3O3571.9579 / 36.3No
219212D structureCHEMBL315613C26H18ClN3O423.93 / 16.1No
222612D structureCHEMBL2381846C27H31N3O4461.5625 / 24.6Yes
4657352D structureCHEMBL3616585C36H34F3N3O4629.688 / 27.7No
4594132D structureCHEMBL3675881C29H23ClF3N3O3553.9668 / 36.0No
235232D structureCHEMBL444343C26H28N2O5448.5196 / 25.0Yes
238852D structureCHEMBL152477C31H30N4O4522.6056 / 26.2No
247452D structureCHEMBL359126C23H16Cl3N3O2472.753 / 26.0No
4659812D structureCHEMBL3616674C32H23F6N3O4627.54311 / 27.1No
255362D structureCHEMBL88045C22H18FN3S375.4654 / 04.5Yes
257292D structureaminothiazole, 24C33H26ClN3O3S580.0996 / 27.2No
4661162D structureCHEMBL3617564C40H57N7O3683.9427 / 28.5No
4661942D structureCHEMBL3616697C35H34F3N3O4S649.7299 / 28.0No
269612D structureCHEMBL154400C27H28ClN3O3477.9894 / 25.6No
277882D structureCID 49864554C155H227N43O50S3524.8356 / 55-16.3No
278922D structureCHEMBL156724C30H30ClN3O4532.0375 / 26.6No
4594622D structureCHEMBL3675865C30H24Cl2F3N3O3602.4358 / 37.2No
290172D structureaminothiazole, 4C33H30F3N3O3S605.6769 / 27.5No
291622D structureCHEMBL1933354C25H29N3O4435.5245 / 24.2Yes
292302D structureCHEMBL219450C30H40F3N3O4563.6627 / 26.5No
293582D structureaminothiazole, 22C30H26F3N3O5S597.60911 / 36.4No
297942D structureCHEMBL416559C24H35NO353.552 / 16.7No
4594712D structureCHEMBL3680845C34H31Cl2N3O3600.545 / 37.7No
4594792D structureCHEMBL3675832C29H21Cl2F4N3O3606.3999 / 36.9No
306072D structureCHEMBL3656280C28H33Cl2N3O4546.4895 / 25.6No
4594842D structureCHEMBL3675894C28H21Cl2F2N3O3556.3917 / 36.1No
5224772D structureCHEMBL3797325C30H27Cl2N3O4564.4635 / 26.0No
311662D structureCHEMBL348555C24H22ClN3387.9112 / 26.1No
313492D structureCHEMBL442389C19H22N2O3326.3964 / 24.5Yes
316892D structureCHEMBL2381840C23H24FN3O4425.466 / 23.5Yes
4594962D structureCHEMBL3675854C29H22Cl2F3N3O3588.4088 / 36.8No
323412D structureCHEMBL197851C28H32F3N7O3571.6059 / 25.5No
331842D structureCHEMBL2159325C27H20Cl2F3N3O4578.3698 / 26.4No
334562D structureCHEMBL345589C20H15N3O3345.3585 / 33.1Yes
4595152D structureCHEMBL3680836C31H30FN3O3511.5976 / 35.9No
4672352D structureCHEMBL3617565C30H27ClF4N2O4591.08 / 37.8No
4595292D structureCHEMBL3675867C29H21Cl3F3N3O3622.858 / 37.5No
4595302D structureCHEMBL3680842C34H27Cl2N3O3596.5085 / 37.6No
360232D structureCHEMBL314238C20H13ClFN3349.7933 / 14.7Yes
4674052D structureCHEMBL3616586C37H35F3N2O5644.6918 / 27.7No
366402D structureCHEMBL218833C31H32F3N3O6599.6079 / 35.9No
366742D structureCHEMBL358249C16H19NO241.3342 / 13.2Yes
369042D structureGRA EX-25C29H36F3N3O5563.6188 / 35.8No
5584042D structureCHEMBL106950C17H13N3O3307.3094 / 31.7Yes
375992D structureCHEMBL430509C20H18N2O3334.3754 / 23.9Yes
377162D structureCHEMBL152348C25H20ClN3O4S493.9626 / 34.9Yes
5340772D structureCHEMBL3943204C30H30ClNO3S520.0844 / 27.8No
5226652D structureCHEMBL3799499C29H25Cl2N3O3534.4374 / 26.0No
388442D structureCHEMBL179181C23H27Cl2N3OS464.4494 / 16.7No
390302D structureCHEMBL2159344C33H33Cl2N3O3590.5454 / 28.1No
394282D structure152121-47-6C21H16FN3OS377.4375 / 13.2Yes
400602D structureCHEMBL159071C26H27FN2O5466.5097 / 25.1No
4595762D structureCHEMBL3675879C28H21Cl2F2N3O3556.3917 / 36.1No
410872D structureCHEMBL346694C24H19ClF3N3O5S553.93710 / 35.7No
412582D structureCHEMBL140514C21H28FNO329.4593 / 15.4No
5340902D structureCHEMBL3939861C30H26ClFN2O3S549.0576 / 27.2No
426072D structureCHEMBL486650C29H30F3N3O6573.5699 / 45.2No
5585932D structureCHEMBL107480C20H15N3O2329.3593 / 33.9Yes

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