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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameVasopressin V1b receptor
SpeciesHomo sapiens (Human)
GeneAVPR1B
SynonymAVPR3
Vasopressin V3 receptor
vasopressin V1b receptor
V3/V1b pituitary vasopressin receptor
V3
[ Show all ]
DiseaseAnxiety disorder
Major depressive disorder; Anxiety
Major depressive disorder
Length424
Amino acid sequenceMDSGPLWDANPTPRGTLSAPNATTPWLGRDEELAKVEIGVLATVLVLATGGNLAVLLTLGQLGRKRSRMHLFVLHLALTDLAVALFQVLPQLLWDITYRFQGPDLLCRAVKYLQVLSMFASTYMLLAMTLDRYLAVCHPLRSLQQPGQSTYLLIAAPWLLAAIFSLPQVFIFSLREVIQGSGVLDCWADFGFPWGPRAYLTWTTLAIFVLPVTMLTACYSLICHEICKNLKVKTQAWRVGGGGWRTWDRPSPSTLAATTRGLPSRVSSINTISRAKIRTVKMTFVIVLAYIACWAPFFSVQMWSVWDKNAPDEDSTNVAFTISMLLGNLNSCCNPWIYMGFNSHLLPRPLRHLACCGGPQPRMRRRLSDGSLSSRHTTLLTRSSCPATLSLSLSLTLSGRPRPEESPRDLELADGEGTAETIIF
UniProtP47901
Protein Data BankN/A
GPCR-HGmod modelP47901
3D structure modelThis predicted structure model is from GPCR-EXP P47901.
BioLiPN/A
Therapeutic Target DatabaseT59881
ChEMBLCHEMBL1921
IUPHAR367
DrugBankBE0000773

Known ligands

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Total entries: 1172
Page:  / 12 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
2112D structureBAS 04995413C23H27N5O4437.56 / 20.7Yes
2142D structure3,6-dichloro-1-benzothiophene-2-carboxylic acidC9H4Cl2O2S247.0893 / 14.1Yes
2882D structureethyl 6-(5-{[(8-bromo-5-methyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)thio]methyl}-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-6-oxohexanoateC22H23BrN6O4S547.4288 / 22.0No
2972D structureBAS 00662566C8H12N4O3S244.2695 / 30.2Yes
4512D structureMLS000686201C17H18N6O2S370.4317 / 11.0Yes
11482D structure868968-75-6C20H18N6O3S422.4638 / 12.0Yes
13472D structure2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N-(2-morpholinoethyl)acetamideC20H21N3O4367.4055 / 11.2Yes
5359552D structureSCHEMBL15987890C26H31ClN4O2467.014 / 14.1Yes
29052D structureAC1N8RBEC19H21N5O5S2463.5279 / 11.7Yes
31382D structureAC1N0YGAC3H7NO4S153.1525 / 2-4.7Yes
33522D structureCHEMBL1643598C20H27N3O4S2437.5737 / 13.4Yes
46442D structureCHEMBL1779411C32H30ClN3O6S620.1178 / 05.6No
53332D structureAC1NLL93C16H16ClN3O5S397.837 / 11.7Yes
5360972D structureSCHEMBL15987910C27H35N5O4493.6086 / 13.0Yes
62442D structureCHEMBL1643587C28H37N3O3S2527.7427 / 15.6No
68282D structureSMR000363287C17H19ClN2O7S2462.9168 / 03.2Yes
71922D structureAC1MQQCVC21H23N5O6S473.5048 / 11.9Yes
5361572D structureSCHEMBL15988159C26H31ClFN5O2500.0155 / 14.7No
74532D structureCHEMBL1221422C24H30ClN5O3471.9865 / 13.5Yes
77352D structureCHEMBL1790720C61H72N12O18S21325.4321 / 15-0.9No
5361832D structureSCHEMBL15987951C26H33N5O3463.5826 / 12.4Yes
82272D structureMLS001029173C24H31N7O3S497.6188 / 21.9Yes
5575122D structureSCHEMBL15987859C27H33ClN6O2509.0516 / 13.9No
5575172D structure2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N'-[(E)-(4-hydroxy-3-methoxyphenyl)methylidene]acetohydrazideC17H18N6O5386.3687 / 20.2Yes
93802D structureCHEMBL1817690C44H69N13O12S21036.2316 / 11-3.5No
95222D structureBAS 09528148C10H14N2O2S226.2944 / 11.9Yes
100582D structurePhenypressinC46H65N15O11S21068.2415 / 13-4.5No
109462D structureAC1ORZTAC15H18N4O5S366.3926 / 2-1.0Yes
111102D structureCHEMBL1778934C32H34N4O2506.654 / 14.9No
114092D structure852168-54-8C15H17N7O3S2407.4679 / 11.2Yes
133772D structureCHEMBL1779415C29H27ClN4O7S611.06610 / 04.0No
135552D structureMLS002154012C18H25N5NaO9P509.38812 / 2N/ANo
5363542D structureSCHEMBL15987978C29H40N6O2504.6796 / 14.4No
139142D structureCHEMBL489386C18H19ClN4O3374.8256 / 02.6Yes
144492D structureSMR000046898C20H19N7O3S2469.5389 / 12.0Yes
145012D structureCHEMBL1778939C30H30N4O2478.5964 / 14.2Yes
148162D structureMLS001095782C22H25ClN6O3456.9317 / 11.8Yes
5363742D structureSCHEMBL15987924C28H36N4O3476.6215 / 13.9Yes
155722D structureCHEMBL1779235C26H33N3O5S499.6266 / 13.4Yes
5577522D structureSCHEMBL15987713C29H37N5O4519.6466 / 13.6No
173192D structureAC1NB7KMC18H21N3O6S2439.5018 / 10.4Yes
5364342D structureSCHEMBL15988088C25H30ClFN6O3517.0027 / 13.0No
174092D structureCHEMBL583082C29H37N3O6S3619.8110 / 14.0No
5577712D structureSCHEMBL15988010C26H31ClN4O2467.014 / 24.0Yes
5220022D structureCHEMBL3719005C20H14F3N3O2385.3466 / 24.0Yes
175522D structureMLS000936813C20H22N6O4S2474.5548 / 21.0Yes
5220102D structureCHEMBL3715676C22H15F3N4O2424.3836 / 34.6Yes
181722D structureCHEMBL1222760C23H28ClN5O2441.964 / 12.7Yes
189702D structureCHEMBL1779229C25H35N3O4S473.6326 / 13.6Yes
190342D structureMLS000936863C19H19N5O3S397.4536 / 12.0Yes
193362D structureCHEMBL1790713C73H85N11O19S21484.6621 / 153.7No
193462D structure5-[(5,7-dioxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)methyl]-N-isopropyl-2-methoxybenzenesulfonamideC18H19N3O5S389.4267 / 11.4Yes
193902D structureCHEMBL1778946C29H28N4O2464.5694 / 14.0Yes
197102D structureN-(5-chloro-2-methylphenyl)-4-(5,7-dioxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)butanamideC18H16ClN3O3357.7944 / 12.3Yes
207122D structureMLS001116560C21H19N3O6S441.4588 / 11.6Yes
4424882D structureCHEMBL3354586C46H73N11O12S1004.2213 / 11-0.2No
217392D structureTerlipressinC52H74N16O15S21227.3819 / 16-5.8No
4655762D structureCHEMBL3186564C23H28ClN3O2413.9463 / 04.6Yes
5579632D structureSCHEMBL15987669C29H35FN4O3506.6226 / 14.2No
221282D structureAC1M7NVAC16H16N4O3312.3295 / 00.7Yes
226222D structureMLS002180522C19H21ClN2O4S408.8975 / 13.9Yes
237282D structureCHEMBL2172288C66H63N9O12S1206.3415 / 74.8No
238812D structure1-methyl-4-oxo-1,4-dihydropyrido[1,2-a]pyrrolo[2,3-d]pyrimidine-2-carboxylic acidC12H9N3O3243.2224 / 10.5Yes
4426232D structureCHEMBL3354600C46H67N11O12S21030.2314 / 11-0.8No
5366122D structureSCHEMBL15988031C26H31ClN4O3483.0094 / 13.4Yes
248542D structure2-ChloroadenosineC10H12ClN5O4301.6878 / 4-0.1Yes
5533842D structureLysipressinC46H65N13O12S21056.2216 / 13-3.9No
253182D structureCHEMBL1819552C39H67N13O11S2958.16515 / 12-4.4No
253512D structureCHEMBL1779406C34H39ClN4O6S667.2188 / 04.7No
261312D structureMLS001116669C21H23N3O5S429.4917 / 02.1Yes
273602D structureMLS001030387C21H23N3O5S429.4917 / 12.4Yes
278512D structureCHEMBL1222761C25H32ClN5O2470.0144 / 13.5Yes
298402D structureCHEMBL572754C30H43N3O7S2621.80810 / 13.4No
300032D structureCHEMBL2369845C46H65N13O11S21040.2314 / 12-2.0No
300062D structureCHEMBL411013C46H65N13O11S21040.2314 / 12-2.0No
306572D structureAC1LCZ0GC12H10Br2N2OS390.0933 / 13.8Yes
5367632D structureSCHEMBL15987869C26H33FN6O4512.5868 / 12.4No
5582272D structureBDBM175032C36H43N5O6S673.82910 / 03.5No
316702D structureCHEMBL1224608C24H27N5O4449.5116 / 31.0Yes
318212D structureCHEMBL1819541C42H65N13O12S21008.1816 / 13-4.5No
319932D structureMLS002279973C13H16KN5O7S425.45711 / 1N/ANo
330562D structurememantineC12H21N179.3071 / 13.3Yes
332642D structureMLS000624310C16H17N5O2S343.4057 / 02.4Yes
4430302D structureCHEMBL3354598C49H71N11O12S1038.2313 / 110.0No
347452D structureCHEMBL575359C27H30ClN3O3S2544.1256 / 14.5No
348862D structureCHEMBL1778945C30H32N4O2480.6124 / 14.5Yes
349582D structureMLS001116679C21H23N3O5S429.4917 / 02.1Yes
351272D structureCyclic AMP sodiumC10H11N5NaO6P351.19110 / 2N/AN/A
358822D structureCHEMBL1817698C44H69N13O12S21036.2316 / 13-4.4No
359732D structurepentoxifyllineC13H18N4O3278.3124 / 00.3Yes
360002D structureCHEMBL576147C27H31ClN4O3S2559.146 / 24.4No
365462D structureCHEMBL1684553C25H30N4O5466.5387 / 11.8Yes
368952D structureMLS000419234C20H13FN2O3348.3335 / 13.6Yes
5226352D structureCHEMBL3718178C20H14F3N3O2385.3466 / 24.0Yes
5369482D structureSCHEMBL15987882C26H30F3N5O3517.5538 / 13.7No
5369652D structureSCHEMBL15987900C27H34ClN5O2496.0524 / 15.1No
384752D structureCHEMBL1779419C31H31ClN4O6S623.1219 / 14.1No
387282D structureethyl 1-[(4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidin-2-yl)carbonyl]piperidine-4-carboxylateC19H19N3O4S385.4386 / 02.1Yes
390802D structureAC1MLIHOC14H18Cl2N2O4S381.2686 / 13.9Yes
4432472D structureCHEMBL3354599C49H71N11O11S1022.2312 / 100.3No

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