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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameGastric inhibitory polypeptide receptor
SpeciesHomo sapiens (Human)
GeneGIPR
SynonymGIP-R
GIP receptor
Glucose-dependent insulinotropic polypeptide receptor
Gippr
DiseaseType 2 diabetes
Length466
Amino acid sequenceMTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLACNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCENPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSFMLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC
UniProtP48546
Protein Data BankN/A
GPCR-HGmod modelP48546
3D structure modelThis predicted structure model is from GPCR-EXP P48546.
BioLiPN/A
Therapeutic Target DatabaseT41750
ChEMBLCHEMBL4383
IUPHAR248
DrugBankN/A

Known ligands

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Total entries: 127
Page:  / 2 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
74952D structureCHEMBL447742C34H41N3O5571.7185 / 46.6No
96952D structureCHEMBL504245C32H31F3N4O5608.6189 / 45.5No
113622D structureCHEMBL1643957C25H24F3N7O2511.5099 / 25.5No
137882D structureCHEMBL1644176C25H24F3N7O2511.5099 / 25.9No
257282D structureaminothiazole, 24C33H26ClN3O3S580.0996 / 27.2No
290162D structureaminothiazole, 4C33H30F3N3O3S605.6769 / 27.5No
293592D structureaminothiazole, 22C30H26F3N3O5S597.60911 / 36.4No
369072D structureGRA EX-25C29H36F3N3O5563.6188 / 35.8No
426062D structureCHEMBL486650C29H30F3N3O6573.5699 / 45.2No
501472D structure643011-22-7C27H21ClF3N3O3S559.9889 / 26.4No
502872D structureaminothiazole, 26C34H26F3N3O4S629.65410 / 27.7No
571582D structureCHEMBL1644198C35H29ClF3N3O4648.0798 / 28.0No
636432D structureCHEMBL217053C18H13BrN2O4401.2165 / 13.5Yes
646442D structureMK 0893C32H27Cl2N3O4588.4855 / 26.8No
668182D structurethiazole, 29C28H22ClF3N2O4S574.9999 / 26.9No
669862D structureaminothiazole, 23C30H26F3N3O4S581.6110 / 36.1No
4718582D structureCHEMBL3616588C36H31F6N3O5699.6512 / 28.6No
754212D structureaminothiazole, 13C32H29F6N3O3S649.65212 / 28.2No
849032D structureCHEMBL577345C76H95FN14O191527.6722 / 18-0.9No
4451152D structureGSK137647AC16H19NO3S305.3924 / 13.5Yes
865792D structureaminothiazole, 5C38H34ClN3O3S648.2186 / 28.9No
880042D structureCHEMBL198387C29H34F3N7O3585.6329 / 25.9No
941312D structureCHEMBL1644174C25H24F3N7O2511.5099 / 25.9No
975052D structureCHEMBL452310C31H31Cl2N3O5596.5055 / 35.9No
985852D structureaminothiazole, 25C34H26F3N3O3S613.6559 / 27.4No
995482D structureCHEMBL2159331C31H22Cl2F3N3O4628.4298 / 27.6No
1096092D structureCHEMBL1644182C25H16Cl2F3N7O2574.3459 / 26.3No
1150052D structureCHEMBL2159342C34H31Cl2N3O3600.544 / 28.0No
1150152D structureaminothiazole, 10C30H27Cl2N3O3S580.5246 / 27.5No
1220952D structureCHEMBL1644185C27H20Cl2F3N3O5594.3689 / 35.8No
1221562D structureCHEMBL1644189C27H19F6N3O5579.45512 / 26.4No
1224672D structureCHEMBL1644199C33H25ClF3N7O2644.0559 / 27.9No
1295922D structureCHEMBL2159340C31H24Cl3N3O3592.9014 / 27.5No
1324262D structureCHEMBL1644183C27H20Cl2F3N3O4578.3698 / 26.4No
1391332D structureCHEMBL1644184C25H16Cl2F3N7O2574.3459 / 26.3No
1412312D structureCHEMBL2159343C33H29Cl2N3O4602.5125 / 27.2No
4472992D structureCHEMBL1644196C29H25ClF3N3O4571.9818 / 26.4No
1529132D structureCHEMBL509710C32H32F3N3O6611.6189 / 45.0No
1535652D structureCHEMBL1644194C28H24F3N3O6S587.5710 / 24.3No
1595922D structurethiazole, 28C28H22ClF3N2O4S574.9999 / 26.9No
1625592D structureCHEMBL1644180C26H17F6N7O3589.45813 / 26.2No
1639922D structureCHEMBL1933363C24H25F3N4O3474.4848 / 34.3Yes
1736832D structureCHEMBL2159341C32H27Cl2N3O3572.4864 / 27.2No
1744272D structureaminothiazole, 16C27H21ClF3N3O3S559.9889 / 26.4No
1745352D structureCHEMBL456738C32H34F3N3O6613.6349 / 45.8No
1924212D structureCHEMBL1922839C31H33F3N8O2606.6549 / 26.4No
1926132D structureCHEMBL1644190C29H23F6N3O5607.50912 / 26.6No
1927402D structureCHEMBL1644197C27H21ClF3N7O2567.9579 / 26.3No
2025802D structureaminothiazole, 9C29H25Cl2N3O3S566.4976 / 27.0No
2075622D structureCHEMBL1644203C29H23F6N3O5607.50912 / 26.6No
2124682D structureCHEMBL487668C30H31Cl2N3O5584.4945 / 46.2No
2170542D structurethiazole, 27C28H22ClF3N2O3S559.08 / 26.6No
2171082D structureCHEMBL452451C32H32F3N3O8S675.67611 / 44.5No
2176162D structureaminothiazole, 12C31H30F3N3O3S581.6549 / 27.3No
2198912D structureCHEMBL1644186C26H18Cl2F3N7O2588.3729 / 25.9No
2212142D structureCHEMBL1644201C26H17F6N7O3589.45813 / 26.2No
2229242D structurethiazole, 30C29H22F6N2O5S624.55413 / 36.6No
2268232D structureCHEMBL1644192C28H24F3N3O6S587.5710 / 24.3No
2273872D structureCHEMBL1922933C33H32ClF3N2O4613.0747 / 28.4No
2298032D structureCHEMBL2159350C33H30ClN3O5584.0696 / 26.1No
2372182D structureCHEMBL445532C31H29BrF3N3O5660.4888 / 45.7No
2430312D structureCHEMBL1644202C27H19F6N3O5579.45512 / 26.4No
2497612D structureCHEMBL1922835C27H24ClF3N8O3600.98710 / 25.7No
2504212D structureCHEMBL1644200C28H21F6N3O5593.48212 / 26.3No
2509982D structureaminothiazole, 3C33H30F3N3O4S621.67510 / 27.8No
2635042D structureCHEMBL2159347C32H27Cl2N3O4588.4855 / 26.8No
2653182D structureCHEMBL1644181C27H20Cl2F3N3O4578.3698 / 26.4No
2688282D structureCHEMBL1922842C28H24F6N8O2618.54412 / 25.6No
2732382D structureCHEMBL1643953C27H28F3N3O4515.5338 / 25.6No
2779442D structureCHEMBL1643954C25H24F3N7O2511.5099 / 25.6No
2788092D structureCHEMBL2159349C33H27ClF3N3O4622.0418 / 27.1No
2795962D structureCHEMBL452311C30H32BrN3O5594.5065 / 45.6No
2809402D structureCHEMBL2159338C32H24Cl2F3N3O4642.4568 / 28.0No
2809422D structureCHEMBL2159337C32H24Cl2F3N3O4642.4568 / 28.0No
2821902D structureCHEMBL2159339C32H24Cl2F3N3O3626.4577 / 27.7No
2845592D structureCHEMBL1644191C29H23F6N3O5607.50912 / 16.5No
2941282D structureCHEMBL453457C31H32F3N3O5S615.6689 / 46.6No
2950902D structureaminothiazole, 15C30H27Cl2N3O3S580.5246 / 26.9No
2952852D structureCHEMBL1644173C27H28F3N3O4515.5338 / 26.0No
2981292D structureCHEMBL2159352C34H30F3N3O4601.6268 / 26.8No
2984642D structureCHEMBL2159327C29H26Cl3N3O4586.8945 / 26.7No
3039142D structureCHEMBL1933360C24H24F3N3O4475.4688 / 24.3Yes
3101242D structureCHEMBL1644187C29H23F6N3O5607.50912 / 26.7No
3139372D structureaminothiazole, 11C31H28F3N3O3S579.6389 / 27.2No
3176522D structureaminothiazole, 1C32H31N3O3S537.6786 / 26.6No
3180052D structureCHEMBL2159351C35H34ClN3O5612.1236 / 27.0No
3203762D structureCHEMBL455214C32H29F4N3O7643.59211 / 45.1No
3223882D structureCHEMBL1644193C26H20F3N7O4S583.54611 / 24.3No
3242572D structureaminothiazole, 6C34H26F3N3O4S629.65410 / 27.7No
3249032D structureaminothiazole, 20C28H24F3N3O4S2587.63211 / 26.6No
3266162D structureCHEMBL528775C31H35N3O5S561.6976 / 45.4No
3338312D structureCHEMBL1644188C27H19F6N7O3603.48513 / 26.6No
3340042D structureCHEMBL1922840C28H24F6N8O2618.54412 / 25.6No
3346442D structureCHEMBL1922834C28H24F6N8O3634.54313 / 25.9No
3482012D structureCHEMBL2159353C33H27F4N3O4605.599 / 26.5No
3524962D structureaminothiazole, 19C28H21F6N3O4S609.54313 / 27.0No
3532472D structureCHEMBL1933365C26H27F3N4O3500.5228 / 34.9No
3533982D structureCHEMBL2159335C30H28Cl3N3O4600.9215 / 27.1No
3555832D structureCHEMBL386446C30H29Cl2N3O4566.4794 / 35.9No
3559302D structureCHEMBL1922841C28H24F6N8O3634.54313 / 25.9No

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