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I-TASSER QUARK LOMETS COACH COFACTOR MetaGO MUSTER CEthreader SEGMER FG-MD ModRefiner REMO DEMO SPRING COTH BSpred ANGLOR BSP-SLIM SAXSTER ThreaDom ThreaDomEx EvoDesign GPCR-I-TASSER BindProf BindProfX SSIPe ResQ IonCom STRUM DAMpred

TM-score TM-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE WDL-RF ATPbind DockRMSD DeepMSA

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameSmoothened homolog
SpeciesMus musculus (Mouse)
GeneSmo
Synonymsmoothened
SMOH
SMO
FZD11
frizzled family member 11
[ Show all ]
DiseaseN/A for non-human GPCRs
Length793
Amino acid sequenceMAAGRPVRGPELAPRRLLQLLLLVLLGGPGRGAALSGNVTGPGPHSASGSSRRDVPVTSPPPPLLSHCGRAAHCEPLRYNVCLGSALPYGATTTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDHFPEGCPNEVQNIKFNSSGQCEAPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMRFGEPTSSETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKKPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGHSDDEPKRIKKSKMIAKAFSKRRELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDVSVTPVATPVPPEEQANMWLVEAEISPELEKRLGRKKKRRKRKKEVCPLRPAPELHHSAPVPATSAVPRLPQLPRQKCLVAANAWGTGESCRQGAWTLVSNPFCPEPSPHQDPFLPGASAPRVWAQGRLQGLGSIHSRTNLMEAEILDADSDF
UniProtP56726
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL6080
IUPHAR239
DrugBankN/A

Known ligands

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Total entries: 351
Page:  / 4 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
5479072D structureCHEMBL3959631C27H30ClN3OS480.0674 / 16.7No
5359522D structureCHEMBL3955601C25H28N6412.5415 / 14.6Yes
41982D structureCHEMBL2152367C17H21NO3287.3593 / 12.6Yes
5360862D structureCHEMBL3938334C30H41N9O543.729 / 12.7No
63892D structureCHEMBL2152368C18H22N2O4330.3844 / 21.4Yes
5361852D structureCHEMBL3983372C25H28FN5O2449.538 / 04.2Yes
4639742D structureCHEMBL3604610C21H15ClN4O2S422.8875 / 24.2Yes
102122D structureCHEMBL497218C26H22N6O2450.5028 / 13.6Yes
107582D structureCHEMBL497238C26H24N6420.526 / 04.5Yes
107592D structureCHEMBL497639C26H24N6420.526 / 04.5Yes
134022D structureCHEMBL1209455C26H22F3N5O477.4918 / 04.4Yes
5363692D structureCHEMBL3920191C25H28N6O2444.5398 / 03.5Yes
5480532D structureCHEMBL3951626C27H24N2O5456.4985 / 24.7Yes
5364242D structureCHEMBL3922084C23H29N7O419.5338 / 11.6Yes
5364322D structureCHEMBL3971451C23H24N2O5408.4545 / 34.3Yes
5364612D structureCHEMBL3965479C27H32N8O2500.6078 / 12.1No
211112D structureCHEMBL474892C28H24F3N3OS507.5757 / 26.1No
211142D structureCHEMBL474893C28H24F3N3OS507.5757 / 26.1No
5481502D structureCHEMBL3978393C29H28ClF3N4O2557.0147 / 17.0No
5365792D structurepropyl 4-{[(4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)carbonyl]amino}benzoateC21H20N2O5380.45 / 23.2Yes
5365882D structureCHEMBL3953149C25H30N6O2446.5558 / 12.7Yes
5366072D structureCHEMBL3921763C26H29F3N6O2514.55311 / 04.8No
5366082D structureSCHEMBL1833847C24H26N6398.5145 / 14.1Yes
252542D structureCHEMBL474302C30H25F3N2O486.5385 / 27.7No
253882D structureCHEMBL2152371C22H29NO5387.4765 / 12.8Yes
265142D structureCHEMBL2043431C22H23N3O3377.4444 / 23.5Yes
5367012D structureSCHEMBL1830420C24H25F3N6O2486.49911 / 14.1No
5481932D structureCHEMBL3960082C27H27ClN4O458.993 / 25.8No
5367322D structure1-ethyl-4-hydroxy-2-oxo-N-(4-oxo-2-pentyl-3(4H)-quinazolinyl)-1,2-dihydro-3-quinolinecarboxamideC25H26N4O4446.5075 / 24.0Yes
5367362D structureCHEMBL3919524C27H27F4N5O513.54110 / 05.1No
298012D structureVismodegibC19H14Cl2N2O3S421.2924 / 13.8Yes
5367702D structureCHEMBL3959511C30H36F3N5O2555.64610 / 06.7No
5368002D structureCHEMBL3903125C27H32F3N7O2543.59511 / 13.3No
319062D structureCHEMBL2160067C28H25ClN6O496.9996 / 25.6No
5482732D structureCHEMBL3906154C23H25ClN4O2424.9295 / 14.9Yes
345212D structureCHEMBL473073C28H24ClN3O453.973 / 25.4No
351102D structureCHEMBL495875C25H24N6O424.5086 / 13.2Yes
5483242D structureCHEMBL3899175C24H26N2O5422.4815 / 24.5Yes
381812D structureCHEMBL473896C31H27F3N2O500.5655 / 27.1No
5370322D structureCHEMBL3959587C25H29F3N6O486.54310 / 13.5Yes
415242D structureCHEMBL2152362C32H33ClN2O4545.0764 / 25.4No
419152D structureCHEMBL2160208C40H41N7O2651.8157 / 25.3No
451852D structureCHEMBL473897C30H26F3N3O501.5536 / 26.0No
5484572D structureCHEMBL3950627C23H23ClN2O5442.8965 / 24.7Yes
5372552D structureCHEMBL3979766C23H22N2O5406.4385 / 23.9Yes
519212D structureCHEMBL474508C29H26F3N3OS521.6027 / 26.5No
5372952D structureCHEMBL3975985C28H32F3N5O511.5939 / 15.0No
5373522D structureSCHEMBL1829533C24H26N4O2402.4985 / 04.2Yes
577012D structureCHEMBL1084738C27H23F3N4O476.5037 / 05.5No
5374742D structureCHEMBL3916441C22H22F3N5413.4488 / 04.4Yes
5375892D structureCHEMBL3930063C21H21F3N6414.4369 / 03.4Yes
4711972D structureCHEMBL3604616C21H14ClFN4O2S440.8776 / 24.3Yes
752312D structureCHEMBL496014C24H23N5381.4835 / 04.4Yes
758612D structureCHEMBL2152372C24H26ClNO3411.9263 / 04.8Yes
762132D structureCHEMBL495608C26H21N7431.5037 / 03.8Yes
5378722D structureAC1MDGI7C19H20N4O5S416.4527 / 24.3Yes
5379152D structureCHEMBL3986486C29H38N8O2530.6779 / 12.5No
5379382D structureSCHEMBL3205103C24H30N6O418.5457 / 12.8Yes
5380282D structureSCHEMBL3200787C25H30N6414.5576 / 04.6Yes
4730852D structureCHEMBL3604612C21H14Cl2N4O2S457.3295 / 24.9Yes
5488802D structureCHEMBL3890551C28H31ClN4O2S523.0925 / 25.8No
851142D structureCHEMBL473892C29H24F3N3O487.5266 / 25.7No
5381252D structureCHEMBL3955346C25H26F3N5453.5138 / 05.2No
5381872D structureCHEMBL3965788C24H26N2O5422.4815 / 24.5Yes
885112D structureCHEMBL523255C27H28N6O452.5626 / 13.5Yes
5382192D structureSCHEMBL3213197C23H27N7O2433.5169 / 02.4Yes
5489662D structureCHEMBL3924243C28H33ClN2O5513.0316 / 15.1No
5382342D structurePurmorphamineC31H32N6O2520.6377 / 16.5No
904082D structureCHEMBL2152381C24H25Cl2N3O4490.3815 / 23.0Yes
908792D structureCHEMBL516370C30H26F3N3O2517.5527 / 25.6No
944562D structureCHEMBL2152370C22H27F3N2O4440.4637 / 23.1Yes
951112D structureCHEMBL2043430C22H17N3O3371.3964 / 23.7Yes
5383582D structureCHEMBL3953985C23H21F6N5481.44611 / 05.3No
5383792D structureCHEMBL3950687C25H28F3N7O499.54210 / 13.9Yes
5383942D structureCHEMBL3974265C30H30N2O5498.5795 / 26.2No
5490942D structureCHEMBL3890227C26H30N2O5450.5355 / 25.6No
5490962D structureCHEMBL3986975C26H31N3O4449.5514 / 35.0Yes
5384582D structureSCHEMBL1835540C26H30N4398.5544 / 04.6Yes
5385122D structureSCHEMBL1834663C24H31N7O433.568 / 11.9Yes
5385292D structureSCHEMBL3213258C24H30N6O2434.5448 / 21.7Yes
5385352D structureSCHEMBL1830461C24H27N5O401.5144 / 13.6Yes
5385552D structureCHEMBL3983242C26H27F3N6O2512.53711 / 04.4No
1068612D structureCHEMBL2152358C26H27ClN2O4466.9624 / 23.5Yes
5386382D structureCHEMBL3899187C24H24F3N5439.4868 / 04.8Yes
1083052D structureCHEMBL497819C26H23N5405.5055 / 04.8Yes
5386502D structureCHEMBL3941789C24H26N2O5422.4815 / 24.5Yes
4764152D structureCHEMBL3604615C21H14ClFN4O2S440.8776 / 24.3Yes
5386792D structureSCHEMBL1832485C25H29N5O415.5414 / 13.6Yes
1153732D structureCHEMBL522241C26H21F3N6474.4919 / 05.0Yes
5493022D structureCHEMBL3909304C28H29F3N2O2482.5476 / 17.2No
5389802D structureCHEMBL3891481C26H33N7O3491.5969 / 31.5Yes
5389832D structureCHEMBL3974732C25H29F3N6O2502.54211 / 13.5No
5390152D structureCHEMBL3903318C26H30N2O5450.5355 / 25.5No
1226092D structureCHEMBL2152369C23H31N3O4413.5185 / 11.3Yes
1248422D structureCHEMBL497003C23H22N6382.4716 / 03.3Yes
1272752D structureCHEMBL514764C29H25F3N2O2490.5266 / 26.2No
1281482D structureCHEMBL496604C25H21ClN6440.9356 / 04.7Yes
4787232D structureCHEMBL3604623C22H16Cl2N4OS455.3575 / 26.2No
1283062D structureCHEMBL2152374C24H26ClN3O4455.9394 / 23.1Yes
5392982D structureSCHEMBL1836304C24H30N6O2434.5448 / 12.9Yes

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