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GPCR

NameD(2) dopamine receptor
SpeciesRattus norvegicus (Rat)
GeneDrd2
SynonymD2 receptor
D2(415) and D2(444)
D2A and D2B
D2R
Dopamine D2 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length444
Amino acid sequenceMDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProtP61169
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL339
IUPHAR215
DrugBankN/A

Known ligands

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Total entries: 5861
Page:  / 59 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
542D structureEMD-23448C23H26N2330.4751 / 14.9Yes
602D structureCHEMBL11640C26H31N3O2417.5535 / 05.0Yes
842D structureEticloprideC17H25ClN2O3340.8484 / 23.1Yes
1282D structureCHEMBL83391C24H24N4O2S2464.6027 / 04.7Yes
1442D structureCHEMBL325386C15H20N2OS276.3983 / 02.7Yes
1812D structurePD-135111C21H27N3S353.5284 / 04.3Yes
2622D structureCHEMBL122047C25H30ClFN4O2472.9894 / 04.5Yes
2722D structureCHEMBL269176C23H32N4O2S428.5956 / 04.6Yes
2742D structure2-{3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl}tetrahydro-1H-pyrrolo[1,2-c]imidazole-1,3(2H)-dioneC20H28N4O3372.4695 / 01.8Yes
2932D structureCHEMBL1783352C24H26N6398.5145 / 13.5Yes
3322D structureCHEMBL300316C18H17FN2O2312.3444 / 11.9Yes
5554802D structurediazepamC16H13ClN2O284.7432 / 03.0Yes
5272D structureCHEMBL314226C15H17FN6300.3415 / 21.6Yes
5479062D structureCHEMBL3883388C27H27Cl2FN4O3545.4367 / 06.0No
6262D structureCHEMBL306197C25H32N2O376.5442 / 16.0No
7102D structureCHEMBL288450C23H26N4O2S422.5476 / 03.2Yes
7442D structureCHEMBL367875C21H27N3OS369.5274 / 03.4Yes
7802D structureCHEMBL542783C23H34ClNO3407.9794 / 2N/AN/A
13962D structureCHEMBL37661C22H27N305.4651 / 05.5No
13982D structureCHEMBL39483C22H27N305.4651 / 05.5No
14542D structureCHEMBL457025C25H35N3O393.5754 / 14.8Yes
14562D structureCHEMBL457024C25H35N3O393.5754 / 14.8Yes
14882D structureCHEMBL3085403C15H22BrClN2O4409.7055 / 4N/AN/A
14922D structureCHEMBL413777C23H31NO2353.5063 / 15.7No
15192D structureCHEMBL121065C22H28N4O3S428.5517 / 03.8Yes
15262D structureBDBM50054356C19H25N5O4387.446 / 11.6Yes
15432D structureTetrahydro-2-[[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methyl]-1H-pyrrolo[1,2-c]imidazole-1,3(2H)-dioneC18H21F3N4O2382.3877 / 02.5Yes
16442D structureCHEMBL574111C13H18ClNO239.7432 / 23.4Yes
18122D structureCHEMBL180319C15H17N3S2303.4424 / 03.0Yes
5215022D structureCHEMBL3741516C27H30FN3O2447.5545 / 04.7Yes
19942D structureCHEMBL545372C22H27Cl2N5OS480.4526 / 3N/AN/A
20322D structureCHEMBL331611C28H28N2392.5461 / 16.3No
20622D structureCHEMBL164195C15H18BrN292.221 / 03.9Yes
21042D structureCHEMBL337696C20H24N2O7S436.4799 / 4N/AN/A
21602D structureCHEMBL81703C25H25FN2O2S436.5455 / 13.9Yes
22502D structureCHEMBL288244C23H22Cl2FN3OS478.4075 / 14.8Yes
23542D structureCHEMBL11590C24H31Br2NO5573.3226 / 2N/ANo
23712D structureCHEMBL1788128C25H30ClFN4S473.0514 / 14.2Yes
23992D structureCHEMBL542298C26H40ClNO2434.0613 / 1N/AN/A
29472D structureCHEMBL290612C25H30N2O3406.5265 / 04.4Yes
29782D structureCHEMBL317532C26H28FNO4437.5116 / 14.9Yes
30712D structureCHEMBL14538C21H24FN3O2369.446 / 13.8Yes
31112D structureCHEMBL1794795C21H28N2O6404.4637 / 2N/AN/A
31902D structureCHEMBL92896C21H24ClFN2O374.8844 / 13.5Yes
32902D structureCHEMBL13120C24H24FN3373.4753 / 15.0Yes
34162D structureCHEMBL135616C22H29BrN2O417.3913 / 14.8Yes
34902D structureCHEMBL134843C17H25NO6339.3887 / 4N/AN/A
5554912D structureFK 1052C18H19N3O293.372 / 13.2Yes
5360042D structuretranylcypromineC9H11N133.1941 / 11.5Yes
36932D structureCHEMBL123048C25H34N4O2S454.6336 / 04.6Yes
37252D structureCID 10665976C20H28N4O2356.474 / 02.2Yes
37522D structureCHEMBL1173017C29H39N5457.6665 / 05.2No
37582D structureCHEMBL542786C20H27NO2313.4413 / 14.5Yes
37632D structureCHEMBL566890C22H26ClN7O2455.9475 / 03.0Yes
37832D structureCHEMBL1204094C24H29N5O2419.5296 / 01.4Yes
37942D structureCHEMBL60185C19H20N2O292.3822 / 23.5Yes
38612D structureCHEMBL180119C24H31NO349.5182 / 05.5No
39432D structureCHEMBL18512C26H26FN3O2S463.5715 / 14.9Yes
41432D structureCHEMBL11311C21H27NO2325.4523 / 04.6Yes
42322D structureCHEMBL418160C27H32ClFN4O483.0283 / 15.1No
42362D structureCHEMBL432972C18H20N4292.3864 / 02.4Yes
44012D structure76149-15-0C16H24N2244.3821 / 14.1Yes
44432D structureCHEMBL298759C21H25BrN2O2417.3473 / 14.6Yes
44442D structureCHEMBL50517C21H25BrN2O2417.3473 / 14.6Yes
45092D structureCHEMBL497604C24H26N4O2402.4985 / 14.0Yes
45432D structureCHEMBL285712C24H25FN2O376.4753 / 14.7Yes
4418872D structureCHEMBL3392290C27H41N3O6503.649 / 4N/ANo
45992D structureCHEMBL135011C16H23NO2261.3653 / 23.4Yes
5479472D structureCHEMBL3883429C22H23Cl2N5O2460.3596 / 03.9Yes
46202D structureCHEMBL95112C23H27FN2O2S414.5396 / 03.4Yes
5555002D structureMoperoneC22H26FNO2355.4534 / 13.0Yes
47832D structureCHEMBL268274C17H25N3O287.4073 / 13.0Yes
49802D structureCHEMBL190525C26H29N5O3459.555 / 23.4Yes
53002D structureCHEMBL12726C25H29F3N4442.536 / 14.8Yes
53622D structureCHEMBL41536C24H26N4O2S434.5586 / 04.3Yes
54112D structureCHEMBL403844C19H19N261.3681 / 03.7Yes
54352D structureCHEMBL283528C19H28ClN3O2365.9024 / 13.5Yes
54382D structureCHEMBL279729C19H28ClN3O2365.9024 / 13.5Yes
54532D structureCHEMBL175226C19H24ClN3OS377.9314 / 02.8Yes
55202D structureCHEMBL121638C24H28N2O3392.4994 / 03.6Yes
55652D structureCHEMBL558026C22H29ClN4O2S2481.077 / 1N/AN/A
56982D structureCHEMBL544909C23H29N5OS423.5796 / 24.5Yes
57092D structureCHEMBL468022C24H37N5S427.6556 / 14.7Yes
57162D structureCHEMBL517962C19H22N4OS354.4726 / 03.9Yes
5555062D structureparoxetineC19H20FNO3329.3715 / 13.5Yes
58492D structureCHEMBL93594C15H23NO3S297.4134 / 02.9Yes
61392D structureCHEMBL3215641C19H24Cl2N2O2S415.3735 / 5N/AN/A
63692D structureCHEMBL545036C26H28ClNO405.9662 / 1N/AN/A
64532D structureCHEMBL1743950C22H21N3327.4312 / 14.2Yes
65152D structureCHEMBL14361C23H25ClN2O4428.9136 / 04.3Yes
68792D structureCHEMBL171519C14H15N3225.2952 / 21.5Yes
69162D structureCHEMBL1744015C19H29N271.4481 / 05.4No
72452D structureCHEMBL426813C21H24ClN3O3401.8915 / 02.6Yes
4419922D structureCHEMBL3215745C19H29Cl2N5O4S494.4328 / 2N/AN/A
73162D structureCHEMBL543613C22H24ClFN2O2S434.9546 / 1N/AN/A
73492D structureCHEMBL179648C21H26N2O322.4523 / 03.7Yes
73772D structureCHEMBL75670C24H27N5OS2465.6347 / 05.2No
74072D structureCHEMBL327836C17H25N3271.4083 / 02.6Yes
75742D structureBDBM50054361C20H28N4O3372.4695 / 11.7Yes
76942D structureCID 44581146C26H30N4O2430.5524 / 23.5Yes

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