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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameMetabotropic glutamate receptor 8
SpeciesRattus norvegicus (Rat)
GeneGrm8
SynonymGLUR8
glutamate receptor
Gprc1h
mGlu8 receptor
mGluR8
[ Show all ]
DiseaseN/A for non-human GPCRs
Length908
Amino acid sequenceMVCEGKRLASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKERCPGYIGLCPRMVTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQINNKSTEYKIIGHWTNQLHLKVEDMQWANREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNINRTGCQRIPIIKLEWHSPWAVVPVFIAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRIFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHTIIDYGEQRTLDPENARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTYISYSNHSI
UniProtP70579
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2718
IUPHAR296
DrugBankN/A

Known ligands

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Total entries: 130
Page:  / 2 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
5573522D structureUS9212196, Derivative 9C13H16Cl2NO8P416.1449 / 5-2.6Yes
5359682D structureCHEMBL3974450C13H16Cl2NO8P416.1449 / 5-2.6Yes
5359882D structureAC1N0YGAC3H7NO4S153.1525 / 2-4.7Yes
5576072D structureUS9212196, Derivative 29C14H20NO8P361.2879 / 5-3.4Yes
5362792D structureCHEMBL3967637C14H20NO8P361.2879 / 5-3.4Yes
129102D structureVU 0361737C13H11ClN2O2262.6933 / 12.6Yes
5365742D structureLSP4-2022C13H18NO8P347.269 / 5-3.8Yes
5222642D structureCHEMBL3786667C8H11NO6217.1777 / 4-4.0Yes
5222712D structureCHEMBL3787264C8H11NO6217.1777 / 4-4.0Yes
5222762D structureCHEMBL3786026C8H11NO6217.1777 / 4-4.0Yes
5222842D structureCHEMBL3786938C8H11NO6217.1777 / 4-4.0Yes
335232D structureCHEMBL2179631C28H27NO5457.5265 / 14.8Yes
5369242D structureCID 57689797C3H8NO6P185.0726 / 3-4.5Yes
5584192D structureUS9212196, Derivative 32C14H17F3NO8P415.25812 / 4-2.1No
5369382D structureCHEMBL3910941C14H17F3NO8P415.25812 / 4-2.1No
5369632D structureCHEMBL3898023C14H19FNO9P395.27611 / 5-3.8No
5584442D structureUS9212196, Derivative 6C14H19FNO9P395.27611 / 5-3.8No
428492D structureMolPort-000-743-361C7H14NO6P239.1646 / 3-4.2Yes
428502D structureAC1MWWXCC7H14NO6P239.1647 / 4-4.8Yes
428542D structureCHEMBL1089515C7H14NO6P239.1647 / 4-4.8Yes
5370852D structureCHEMBL3969216C14H19ClNO9P411.72810 / 5-3.2Yes
5585992D structureUS9212196, Derivative 7C14H19ClNO9P411.72810 / 5-3.2Yes
5199552D structureD-AP4C4H10NO5P183.16 / 4-5.5Yes
5374002D structure2-amino-4-phosphonobutanoic acidC4H10NO5P183.16 / 4-5.5Yes
572832D structureL-AP4C4H10NO5P183.16 / 4-5.5Yes
628572D structureCHEMBL396319C11H14NO5P271.2096 / 4-3.3Yes
628662D structureCHEMBL392420C11H14NO5P271.2096 / 4-3.3Yes
5375002D structureCHEMBL3980977C14H17F3NO7P399.25911 / 4-2.4No
5592182D structureUS9212196, Derivative 33C14H17F3NO7P399.25911 / 4-2.4No
5375252D structure(RS)-MCPGC10H11NO4209.2015 / 3-2.0Yes
5376322D structureCHEMBL3895389C14H20NO8P361.2879 / 4-3.3Yes
5593902D structureUS9212196, Derivative 31C14H20NO8P361.2879 / 4-3.3Yes
5594762D structureUS9212196, Derivative 19C15H22NO9P391.31310 / 5-3.5Yes
5376852D structureCHEMBL3941586C15H22NO9P391.31310 / 5-3.5Yes
822712D structureCHEMBL3298273C15H13FN2O2272.2794 / 12.1Yes
850682D structureCHEMBL1076865C7H13ClNO6P273.6067 / 4-4.1Yes
1003732D structureSCHEMBL8239107C8H14NO6P251.1757 / 3-4.7Yes
5537672D structureMSOPC4H10NO6P199.0997 / 4-5.0Yes
1092962D structure(2S,1'S,2'S)-2-(carboxycyclopropyl)glycineC6H9NO4159.1415 / 3-3.4Yes
1103822D structureBDBM50100942C5H9NO5163.1295 / 3-3.4Yes
1103852D structure2485-33-8C5H9NO5163.1296 / 4-4.1Yes
5387342D structureCHEMBL3912541C15H22NO8P375.3149 / 5-3.1Yes
5607982D structureUS9212196, Derivative 10C15H22NO8P375.3149 / 5-3.1Yes
5608452D structureCHEMBL404886C25H16FN5O2437.4346 / 23.6Yes
5388822D structureCHEMBL3927149C14H18NO10P391.26911 / 6-4.3No
5609452D structureUS9212196, Derivative 23C14H18NO10P391.26911 / 6-4.3No
5388992D structureCHEMBL3913188C14H19FNO8P379.27710 / 4-3.2Yes
5609632D structureUS9212196, Derivative 34C14H19FNO8P379.27710 / 4-3.2Yes
5538812D structureMAP4C5H12NO5P197.1276 / 4-4.6Yes
1284462D structureL-PHOSPHINOTHRICINC5H12NO4P181.1285 / 3-5.0Yes
1303222D structuredemethylphosphinothricinC4H10NO4P167.1015 / 3-5.1Yes
5539502D structurecppgC11H14NO5P271.2096 / 4-3.1Yes
1350112D structure(S)-3,4-DCPGC10H9NO6239.1837 / 4-2.7Yes
5615232D structureUS9212196, Derivative 28C13H16F2NO8P383.24111 / 5-3.6No
5394232D structureCHEMBL3896442C13H16F2NO8P383.24111 / 5-3.6No
5394532D structureCHEMBL3905370C13H18NO7PS363.3219 / 5-3.3Yes
5615532D structureUS9212196, Derivative 26C13H18NO7PS363.3219 / 5-3.3Yes
1385282D structureCHEMBL1093612C9H18NO7P283.2178 / 5-5.1Yes
5398002D structureCHEMBL3982807C15H22NO10P407.31211 / 5-3.9No
5619302D structureUS9212196, Derivative 4C15H22NO10P407.31211 / 5-3.9No
1582952D structure(RS)-PPGC8H10NO5P231.1446 / 4-3.7Yes
1819562D structureCHEMBL197976C5H10NO5P195.1116 / 4-4.7Yes
1819662D structureCHEMBL199626C5H10NO5P195.1116 / 4-4.7Yes
1819692D structureCHEMBL442076C5H10NO5P195.1116 / 4-4.7Yes
1870142D structureCHEMBL140197C6H9NO5175.146 / 4-3.9Yes
1870252D structureCHEMBL357043C6H9NO5175.146 / 4-3.9Yes
5408992D structureCHEMBL3917132C15H20NO11P421.29512 / 6-4.3No
5632282D structureUS9212196, Derivative 18C15H20NO11P421.29512 / 6-4.3No
1892272D structureCHEMBL2373733C21H16ClN3O3393.8274 / 12.6Yes
5410032D structureCHEMBL3935255C14H20NO9P377.28610 / 5-3.9Yes
5633282D structureUS9212196, Derivative 3C14H20NO9P377.28610 / 5-3.9Yes
2010202D structureDcg-IVC7H9NO6203.157 / 4-4.3Yes
2136382D structureVU0366037-2C19H13Cl2N3O2386.2323 / 24.1Yes
2221892D structureCHEMBL1204419C9H17ClNO7P317.6598 / 6N/ANo
5507222D structureCHEMBL3894544C12H19NO9P2383.2310 / 6-5.2No
5644602D structureUS9212196, Derivative 14C12H19NO9P2383.2310 / 6-5.2No
5421012D structureCHEMBL3890165C14H17F3NO9P431.25713 / 5-2.7No
5645532D structureUS9212196, Derivative 20C14H17F3NO9P431.25713 / 5-2.7No
5423002D structureCHEMBL3966924C14H19N2O11P422.28312 / 5-4.0No
5647552D structureUS9212196, Derivative 5C14H19N2O11P422.28312 / 5-4.0No
5427442D structureMPPGC9H12NO5P245.1716 / 4-3.5Yes
5427812D structure(2s)-2-amino-4-sulfinobutanoic acidC4H9NO4S167.1796 / 3-3.8Yes
2591282D structureCHEMBL1092315C9H16NO8P297.29 / 5-5.3Yes
5430342D structureCHEMBL3909874C14H19ClNO8P395.7299 / 4-2.7Yes
5655232D structureUS9212196, Derivative 35C14H19ClNO8P395.7299 / 4-2.7Yes
2653372D structureCHEMBL2179646C26H22ClNO3431.9163 / 15.6No
5435582D structureCHEMBL3982457C14H18NO7P343.2728 / 5-3.5Yes
5659812D structureUS9212196, Derivative 11C14H18NO7P343.2728 / 5-3.5Yes
2828132D structureCHEMBL1089852C6H12NO6P225.1377 / 4-4.7Yes
5660502D structureBDBM50314796C7H12NO6P237.1487 / 4-2.1Yes
2923302D structureCHEMBL2179629C24H18ClNO4S451.9215 / 15.3No
3105672D structureCHEMBL243925C4H10NO4PS199.1616 / 4-3.8Yes
5444792D structureMDMAC11H15NO2193.2463 / 12.2Yes
3164492D structureCID 46197877C9H16NO6P265.2027 / 3-4.4Yes
3196622D structureCID 46197879C6H12NO7P241.1368 / 5-5.3Yes
3239222D structure61350-00-3C12H9ClN2O232.6672 / 12.6Yes
5448262D structureCHEMBL3896964C13H20NO7P333.2778 / 5-4.1Yes
5675402D structureUS9212196, Derivative 13C13H20NO7P333.2778 / 5-4.1Yes
5677052D structureUS9212196, Derivative 21C14H17F3NO8P415.25812 / 5-3.0No
5449572D structureCHEMBL3918221C14H17F3NO8P415.25812 / 5-3.0No

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