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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameThyrotropin-releasing hormone receptor
SpeciesRattus norvegicus (Rat)
GeneTrhr
SynonymThyroliberin receptor
TRH receptor
TRH-R
TRH-R1
TRH1 receptor
DiseaseN/A for non-human GPCRs
Length412
Amino acid sequenceMENETVSELNQTELPPQVAVALEYQVVTILLVVVICGLGIVGNIMVVLVVMRTKHMRTATNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVMPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNKNMNLNTTNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKAANYSVALNYSVIKESDRFSTELDDITVTDTYVSTTKVSFDDTCLASEKNGPSSCTYGYSLTAKQEKI
UniProtQ01717
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4553
IUPHAR363
DrugBankN/A

Known ligands

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Total entries: 26
Page:  / 1 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
5532482D structurediazepamC16H13ClN2O284.7432 / 03.0Yes
237062D structureCHEMBL382080C22H32N6O4444.5365 / 4-0.3Yes
300952D structureCHEMBL2371826C21H25F3N6O7530.46110 / 4N/ANo
5535222D structuremidazolamC18H13ClFN3325.7713 / 02.5Yes
5535512D structureMeTRHC17H24N6O4376.4175 / 3-2.3Yes
763472D structureondansetronC18H19N3O293.372 / 02.3Yes
859262D structureCHEMBL370700C19H25N6O5+417.4465 / 4-3.0Yes
5491122D structureCHEMBL3897627C32H30N4O3518.6175 / 33.0No
1090342D structureCHEMBL191346C22H31N6O5+459.5275 / 4-2.0Yes
1090352D structureCHEMBL2371830C22H31N6O5+459.5275 / 4-2.0Yes
1181952D structureCHEMBL369944C26H36N6O4496.6125 / 40.4Yes
1452982D structureCHEMBL198263C19H26N6O4402.4555 / 4-1.9Yes
1798022D structureCHEMBL381666C19H28N6O4404.4715 / 4-1.3Yes
1879912D structureCHEMBL2371825C21H29N6O5+445.55 / 4-2.3Yes
1879922D structureCHEMBL190578C21H29N6O5+445.55 / 4-2.3Yes
5409712D structureSCHEMBL3132248C14H21N5O5339.3525 / 4-3.7Yes
2199752D structureCilansetronC20H21N3O319.4082 / 02.6Yes
2199852D structureImidazol-1-yl compound 1C20H21N3O319.4082 / 02.6Yes
2788242D structureCHEMBL382714C20H30N6O4418.4985 / 4-0.8Yes
2870192D structureCHEMBL2371831C20H27N6O5+431.4735 / 4-2.7Yes
2870202D structureCHEMBL362358C20H27N6O5+431.4735 / 4-2.7Yes
3515182D structureCHEMBL197149C19H28N6O4404.4715 / 4-1.3Yes
3526542D structureCHEMBL3099899C26H21Cl2N3O3494.3725 / 15.0Yes
3757082D structureCHEMBL365775C23H31N9O5513.5598 / 4-2.7No
3966012D structureprotirelinC16H22N6O4362.395 / 4-2.5Yes
5472312D structureCHEMBL3906398C24H27N5O7497.5087 / 4-1.3Yes

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