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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameMetabotropic glutamate receptor 1
SpeciesHomo sapiens (Human)
GeneGRM1
SynonymGPRC1A
SCAR13
glutamate receptor, metabotropic 1
wobl
glutamate receptor
[ Show all ]
DiseasePain
Schizophrenia
Neuropathic pain
Neurological disease
Alzheimer disease; Huntington's disease
Length1194
Amino acid sequenceMVGLLLFFFPAIFLEVSLLPRSPGRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPDGQSLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKAGAGNANSNGKSVSWSEPGGGQVPKGQHMWHRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDTSTKTLYNVEEEEDAQPIRFSPPGSPSMVVHRRVPSAATTPPLPSHLTAEETPLFLAEPALPKGLPPPLQQQQQPPPQQKSLMDQLQGVVSNFSTAIPDFHAVLAGPGGPGNGLRSLYPPPPPPQHLQMLPLQLSTFGEELVSPPADDDDDSERFKLLQEYVYEHEREGNTEEDELEEEEEDLQAASKLTPDDSPALTPPSPFRDSVASGSSVPSSPVSESVLCTPPNVSYASVILRDYKQSSSTL
UniProtQ13255
Protein Data Bank3ks9, 4or2
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 3ks9.
BioLiPBL0174211,BL0174213, BL0271872,BL0271873,BL0271874,, BL0271871,BL0271876, BL0174210,BL0174212
Therapeutic Target DatabaseT27137
ChEMBLCHEMBL3772
IUPHAR289
DrugBankBE0000824

Known ligands

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Total entries: 1302
Page:  / 14 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
4631282D structureCHEMBL3634421C20H12F2N2O4382.3236 / 13.3Yes
29292D structureCHEMBL224615C17H14N4OS322.3865 / 03.2Yes
41362D structureCHEMBL578580C16H12FN3OS313.355 / 03.0Yes
42472D structureCHEMBL1783868C20H18N4OS362.4515 / 14.7Yes
49442D structureCHEMBL1099113C23H16N2320.3952 / 05.6No
55632D structureCHEMBL576121C16H13N3OS295.364 / 02.9Yes
5216252D structureCHEMBL3787159C21H15Cl2N3O2412.273 / 14.2Yes
63102D structureCHEMBL1951882C19H14BrN3OS412.3054 / 14.9Yes
4419562D structureCHEMBL334842C6H9N3O3S203.2166 / 3-3.4Yes
4419622D structureCHEMBL131922C6H9N3O3S203.2166 / 3-3.4Yes
5361352D structureCHEMBL3899832C22H19N5O4417.4258 / 23.6Yes
72012D structureCHEMBL238262C17H11N5OS333.3695 / 13.1Yes
77902D structureCHEMBL224322C21H24N4OS380.515 / 04.3Yes
79942D structureCHEMBL386408C17H21N5O2S359.4486 / 02.3Yes
82692D structureCHEMBL2208408C15H15ClN2O3S338.8064 / 12.6Yes
86932D structureCHEMBL607689C20H22FN3323.4153 / 03.6Yes
4639442D structureCHEMBL3628092C17H10ClN5O3367.7495 / 21.9Yes
5217192D structureCHEMBL3786967C20H13Cl2N3O2398.2433 / 13.9Yes
4641282D structureCHEMBL3634415C21H16N2O4360.3694 / 13.4Yes
104062D structureCHEMBL2426616C14H14N2O2S274.3384 / 02.3Yes
108152D structureCHEMBL1783862C19H15FN4O2S382.4137 / 13.8Yes
117752D structureCHEMBL1645351C22H30N4O2S413.5685 / 04.6Yes
117762D structureCHEMBL1771388C22H30N4O2S413.5685 / 04.6Yes
4593232D structureCHEMBL1645351C22H30N4O2S414.5685 / 04.6Yes
4421622D structureCHEMBL3398289C19H17N3O3335.3635 / 02.3Yes
133152D structureQUISQUALIC ACIDC5H7N3O5189.1276 / 3-3.9Yes
135722D structureCHEMBL511355C18H22N4O2326.44 / 02.4Yes
141972D structureCHEMBL235975C18H14N4O2S350.3966 / 13.2Yes
5218952D structureCHEMBL3786739C20H15ClN2O3366.8013 / 13.7Yes
5555422D structure2Me4CPGC10H11NO4209.2015 / 3-1.8Yes
5219012D structureCHEMBL3786738C18H13ClN4O3368.7775 / 12.0Yes
152172D structureCHEMBL2334981C24H26ClN5OS468.0165 / 2N/AN/A
153482D structureCHEMBL388087C18H16N4OS336.4135 / 03.1Yes
4422542D structureCHEMBL3422865C22H21N5O2S419.5035 / 23.9Yes
155752D structureCHEMBL1951670C18H14N2O3S338.3815 / 03.6Yes
5555432D structureSCHEMBL6909945C12H7N7O4313.2335 / 2-0.1Yes
4648422D structureCHEMBL3628098C19H10Cl2N2O4401.1994 / 14.3Yes
160062D structureCHEMBL300330C7H12N2O4188.1836 / 3-6.0Yes
162282D structureCHEMBL213102C16H15NO2253.3013 / 03.1Yes
162742D structureCHEMBL1269131C31H48N6O3552.7646 / 62.2No
5174102D structureCHEMBL3644417C20H22N4O2350.4224 / 01.5Yes
5219742D structureCHEMBL3787140C21H17ClN2O4396.8274 / 13.7Yes
170482D structureCHEMBL493571C14H11N3O237.2623 / 12.1Yes
172262D structureCHEMBL2205923C16H12BrN5OS402.276 / 03.6Yes
4423712D structureCHEMBL3422867C22H20FN5O2S437.4936 / 24.0Yes
5220332D structureCHEMBL3787654C20H13Cl3N2O3435.6853 / 15.0Yes
194782D structureCHEMBL1784054C18H14ClN5OS383.8546 / 14.6Yes
4424672D structureCHEMBL3398288C18H14ClN3O2339.7794 / 02.9Yes
203092D structureCHEMBL319279C28H27NO5457.5266 / 32.1Yes
4653782D structureAC1N2AWGC24H24N2O4S436.5265 / 14.1Yes
208592D structureCHEMBL426018C20H20N4OS364.4675 / 04.5Yes
208782D structureCHEMBL233708C16H26N2O4310.3944 / 22.6Yes
4425002D structureCHEMBL3398283C19H14F2N2O2340.335 / 03.2Yes
4425182D structureCHEMBL3330817C19H13FN2O2S352.3835 / 04.2Yes
236752D structureCHEMBL224375C18H13F3N4OS390.3848 / 04.1Yes
239252D structureCHEMBL225124C17H13FN4OS340.3766 / 03.3Yes
4594272D structureCHEMBL3702371C22H22N2O3362.4294 / 03.2Yes
4426472D structureCHEMBL3422887C22H18FN3OS391.4645 / 14.8Yes
250912D structureCHEMBL523693C20H12N2280.332 / 04.3Yes
253542D structureCHEMBL1093561C16H14N6OS338.3897 / 22.7Yes
4594412D structureCHEMBL3702413C17H15IN4O2434.2374 / 10.8Yes
262492D structureCHEMBL2205916C19H17N5O2S379.4387 / 13.4Yes
262702D structureCHEMBL1269126C31H49N5O2523.7665 / 54.5No
5223862D structureCHEMBL3785813C20H15ClN2O3366.8013 / 13.7Yes
283172D structureCHEMBL2418357C19H26N4O326.4443 / 02.1Yes
4428392D structureCHEMBL3398278C19H16ClN3O2353.8064 / 03.4Yes
5224602D structureCHEMBL3759867C19H11Cl2N3O4416.2145 / 13.7Yes
4594832D structureCHEMBL3702393C22H22N6O386.4594 / 01.8Yes
4594892D structureCHEMBL3702438C22H18FN7O415.4327 / 01.6Yes
310392D structureCHEMBL3122222C17H19N5O2325.3725 / 12.0Yes
4667342D structureCHEMBL3628111C20H12Cl2N2O4415.2264 / 14.3Yes
316232D structureCHEMBL178592C19H22ClNO2331.843 / 04.7Yes
316322D structureCHEMBL1951688C18H15N3OS321.3984 / 14.0Yes
320672D structureCHEMBL1269127C31H57N5O2531.835 / 55.0No
4668972D structureCHEMBL3628083C19H12ClN3O3365.7733 / 23.0Yes
325262D structureCHEMBL469121C18H14FN3O307.3284 / 13.1Yes
326122D structureCHEMBL1951666C19H16FN3O2S369.4146 / 03.9Yes
5225642D structureCHEMBL3787296C19H13Cl2N3O2S418.2924 / 14.4Yes
346152D structureCHEMBL2397355C15H23N3O261.3693 / 02.4Yes
348322D structureCHEMBL2334976C23H23N5OS417.5315 / 14.1Yes
5225862D structureCHEMBL3785252C21H17ClN2O3380.8283 / 14.2Yes
354252D structureCHEMBL418462C13H15ClN2O4298.7236 / 3-3.9Yes
356932D structureCHEMBL245991C17H12ClN5O337.7674 / 02.6Yes
357482D structureCHEMBL1099112C17H11ClN2278.7392 / 04.6Yes
357922D structureBDBM50388941C16H13N3O3295.2985 / 11.4Yes
4595402D structureCHEMBL3644383C21H21N5O359.4334 / 01.1Yes
362542D structureCHEMBL453249C17H21N5O2327.3885 / 01.4Yes
364772D structureCHEMBL568451C19H18N4O318.384 / 03.0Yes
4674962D structureCHEMBL3605296C20H17N5O3375.3886 / 12.1Yes
4595542D structureCHEMBL3702428C22H19N5O369.4284 / 02.0Yes
4677232D structureCHEMBL3634432C21H15FN2O5394.3586 / 13.1Yes
394242D structureCHEMBL567584C18H14N4286.3383 / 03.6Yes
399622D structureCHEMBL1783875C19H14N4OS346.4085 / 13.5Yes
4678392D structureCHEMBL3628281C19H16ClN3O3369.8054 / 12.5Yes
401772D structureCHEMBL1093902C16H10F3N5OS377.3459 / 13.3Yes
406382D structureCHEMBL3122225C19H21N5O2351.415 / 02.3Yes
406532D structureCHEMBL1784080C21H18N4OS374.4625 / 14.1Yes
407342D structureCHEMBL2397377C20H28N4O340.4714 / 02.9Yes
409552D structureCHEMBL1257182C19H22F3N5O2S441.4738 / 22.8Yes
410852D structureCHEMBL1234889C23H28F3N5O2S495.5658 / 34.2Yes

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