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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameCorticotropin-releasing factor receptor 2
SpeciesHomo sapiens (Human)
GeneCRHR2
SynonymCRFR-2
CRFR2beta
CRH-R2
CRFR2alpha
CRFR2
[ Show all ]
DiseaseAnxiety disorder
Congestive heart failure
Eating disorders stimulate food consumption anxiety
Generalized anxiety disorder
Length411
Amino acid sequenceMDAALLHSLLEANCSLALAEELLLDGWGPPLDPEGPYSYCNTTLDQIGTCWPRSAAGALVERPCPEYFNGVKYNTTRNAYRECLENGTWASKINYSQCEPILDDKQRKYDLHYRIALVVNYLGHCVSVAALVAAFLLFLALRSIRCLRNVIHWNLITTFILRNVMWFLLQLVDHEVHESNEVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTERLRKCLFLFIGWCIPFPIIVAWAIGKLYYENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRSAVRKRWHRWQDHHSLRVPMARAMSIPTSPTRISFHSIKQTAAV
UniProtQ13324
Protein Data BankN/A
GPCR-HGmod modelQ13324
3D structure modelThis predicted structure model is from GPCR-EXP Q13324.
BioLiPN/A
Therapeutic Target DatabaseT11011
ChEMBLCHEMBL4069
IUPHAR213
DrugBankN/A

Known ligands

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Total entries: 62
Page:  / 1 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
4640622D structure195055-03-9C22H32N6380.545 / 04.7Yes
114732D structureCHEMBL2370927C183H307N47O564061.7463 / 55-17.2No
145432D structureCHEMBL426607C21H24Cl2N4O419.353 / 05.2No
196312D structureCHEMBL2370916C211H362N58O664767.5673 / 64-23.3No
229372D structureCHEMBL2370940C183H305N47O554043.7361 / 54-14.5No
244812D structureCHEMBL427807C204H337N63O644696.3271 / 69-18.8No
4670582D structureCHEMBL186203C20H24Cl2N4O407.3394 / 15.2No
354442D structureCHEMBL2370939C186H312N52O554156.8562 / 57-16.7No
361712D structureCHEMBL1794007C160H266N50O443594.1951 / 50-12.6No
432162D structureCHEMBL1794010C157H263N45O443485.149 / 47-9.3No
441922D structureCipargaminC19H14Cl2FN3O390.2393 / 33.9Yes
458572D structureCHEMBL2369741C158H267N47O433513.1649 / 48-9.9No
4702492D structureCHEMBL186252C23H31BrN4O459.4324 / 15.8No
620212D structureUNII-7FC996ZZL5C21H29N5O3399.4957 / 03.0Yes
634742D structureCHEMBL2370921C182H305N49O544043.7361 / 55-15.5No
684612D structureCHEMBL184938C21H28Cl2N4O423.3823 / 06.3No
873982D structureCID 44290454C202H349N57O63S4616.4171 / 63-24.0No
924592D structureCHEMBL2372650C208H344N60O63S24757.5272 / 64-15.4No
4600422D structureCHEMBL265635C208H344N60O63S24757.5272 / 64-15.4No
1103282D structureCHEMBL2370931C163H272N50O443636.2751 / 50-11.3No
5538892D structureAstressinC161H269N49O423563.2249 / 51-8.0No
1211322D structureCHEMBL1794009C161H269N49O423563.2249 / 48-9.1No
1282162D structureCHEMBL2370914C170H286N44O503746.4257 / 50-15.8No
4798132D structureCHEMBL3628739C161H274N48O46S3650.3155 / 53-20.2No
1393442D structureCHEMBL2370917C183H307N51O534069.7759 / 55-14.4No
1654972D structureCHEMBL2370938C185H314N50O534086.8460 / 55-14.5No
4834242D structureCHEMBL3628728C20H24Br2N4O496.2474 / 15.4No
1681122D structureBDBM50158983C202H345N55O64S4600.3671 / 64-19.2No
4607222D structureUNII-O90RQ1XQ79C29H39N3O4493.6486 / 04.6Yes
1836632D structurePEXACERFONTC18H24N6O340.4316 / 13.8Yes
4874242D structureCHEMBL3628729C22H29BrN4O445.4054 / 15.5No
4876202D structureCHEMBL189089C22H30N4O2382.5085 / 14.3Yes
2057402D structureCHEMBL484158C19H23ClFN5O391.8756 / 15.4No
4885942D structureCHEMBL3628734C24H33BrN4O473.4594 / 16.4No
2077042D structureCHEMBL2179195C26H37N3O5S503.6588 / 04.8No
2286472D structureUNII-YP6748BALIC36H47N3O7S665.8469 / 1N/ANo
2409262D structureCHEMBL506214C20H27N5O2369.4696 / 14.5Yes
2411402D structureCHEMBL110609C19H24Cl2N4379.3293 / 05.8No
2641462D structureUNII-D8690V3244C208H343N59O64S24758.573 / 67-13.6No
2651842D structureCHEMBL1794006C161H271N49O433581.2451 / 49-11.8No
2700282D structureCHEMBL2369740C163H271N49O443621.2651 / 49-8.8No
2741722D structureCHEMBL2369693C160H265N49O453595.1852 / 50-12.0No
2745722D structureCHEMBL2368116C181H305N49O544031.7261 / 55-15.4No
2760692D structureBDBM50313853C205H339N59O63S4670.3871 / 64-19.4No
4616052D structureCHEMBL1790241C205H339N59O63S4670.3871 / 64-19.4No
3019182D structureCHEMBL483993C22H31N5O3413.5227 / 03.4Yes
5015552D structureCHEMBL3628735C21H27BrN4O431.3784 / 15.0Yes
3211682D structureCHEMBL2370915C170H284N44O493728.455 / 49-13.1No
5046592D structureCHEMBL3628736C21H27BrN4O431.3784 / 15.0Yes
3396972D structureCHEMBL2370941C187H315N49O564145.8663 / 56-14.3No
3425742D structureCHEMBL2370929C184H310N50O554102.862 / 56-16.3No
3563102D structureCP-376395C21H30N2O326.4843 / 16.4No
5075852D structureCHEMBL3628733C22H30N4O366.5094 / 14.7Yes
3693752D structureCHEMBL2370930C178H302N56O463962.7255 / 55-15.5No
3915892D structureCHEMBL2370920C180H299N47O554001.6561 / 54-15.8No
3992332D structureCHEMBL128100C18H19Cl3F3N3S472.7767 / 17.1No
4037782D structureCHEMBL2370924C185H312N50O534084.8360 / 55-14.8No
4094872D structureCHEMBL295563C22H30N4O2382.5085 / 04.9Yes
4096382D structureCHEMBL2370926C185H310N48O564102.7962 / 55-15.3No
4108532D structureCHEMBL2373995C210H340N62O67S24869.5276 / 67-18.9No
4229022D structureCHEMBL2369694C159H266N48O423522.1749 / 48-9.0No
4400282D structureCHEMBL2370933C182H305N49O544043.7361 / 55-15.5No

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