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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameMetabotropic glutamate receptor 4
SpeciesHomo sapiens (Human)
GeneGRM4
SynonymmGluR4
mGlu4 receptor
GPRC1D
glutamate receptor
DiseaseAnxiety disorder
Neurological disease
Length912
Amino acid sequenceMPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTYVTYTNHAI
UniProtQ14833
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseT99402
ChEMBLCHEMBL2736
IUPHAR292
DrugBankBE0000833

Known ligands

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Total entries: 1018
Page:  / 11 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
4412D structureCHEMBL2023454C18H12FN3289.3133 / 03.9Yes
5173222D structureCHEMBL3952345C13H10N4O4S318.3076 / 10.6Yes
5173232D structureCHEMBL3939625C16H11Cl2N3O3S2428.3026 / 13.7Yes
4631292D structureCHEMBL3634421C20H12F2N2O4382.3236 / 13.3Yes
5554832D structureSCHEMBL16607448C25H16F4N2O3468.4087 / 05.4No
4592472D structureSCHEMBL2360200C13H11FN4O258.2565 / 22.5Yes
23742D structureCHEMBL1921958C15H15N3O3S317.3635 / 11.3Yes
38832D structureCHEMBL1830907C15H12N6S308.3636 / 22.8Yes
49432D structureCHEMBL1099113C23H16N2320.3952 / 05.6No
54202D structureCHEMBL1209518C13H13N3O227.2674 / 12.5Yes
57172D structureCHEMBL2022873C16H11N3S277.3453 / 03.8Yes
65062D structureCHEMBL2023452C19H15N3285.352 / 04.2Yes
4419582D structureCHEMBL334842C6H9N3O3S203.2166 / 3-3.4Yes
4419632D structureCHEMBL131922C6H9N3O3S203.2166 / 3-3.4Yes
5216492D structureCHEMBL3809272C17H14FN3O3S359.3755 / 12.5Yes
5361252D structureCHEMBL3899832C22H19N5O4417.4258 / 23.6Yes
70852D structureCHEMBL1830903C14H12FN5S301.3436 / 23.2Yes
4592902D structureSCHEMBL6923581C20H13ClN8O416.8298 / 13.5Yes
82662D structureCHEMBL2208408C15H15ClN2O3S338.8064 / 12.6Yes
82962D structureVU0405623-1C20H11Cl2N3O3412.2264 / 13.8Yes
87292D structureCHEMBL1209746C16H15N3O3297.3145 / 12.7Yes
5173642D structureCHEMBL3986822C17H11ClF3N3O3S2461.8589 / 14.0Yes
4420792D structureCHEMBL3357575C21H14ClN3O3391.8114 / 13.5Yes
95852D structureCHEMBL1909433C16H11ClN4O2S358.85 / 22.8Yes
100762D structureCHEMBL1209663C13H10N4222.2514 / 11.9Yes
101312D structure1-(6-chloro-3-pyridyl)-2-imidazol-1-ylethanoneC10H8ClN3O221.6443 / 01.4Yes
101972D structureCHEMBL1672256C21H13ClFN3O2393.8024 / 14.4Yes
4641292D structureCHEMBL3634415C21H16N2O4360.3694 / 13.4Yes
104052D structureCHEMBL2426616C14H14N2O2S274.3384 / 02.3Yes
108462D structureCHEMBL1223384C19H15ClN2O3S386.854 / 13.4Yes
4593212D structureSCHEMBL6923296C19H12ClFN4O366.785 / 24.5Yes
4593332D structureSCHEMBL6922895C16H18N4266.3483 / 24.1Yes
129042D structureVU 0361737C13H11ClN2O2262.6933 / 12.6Yes
132462D structureN-(6-methoxypyrimidin-4-yl)picolinamideC11H10N4O2230.2275 / 10.9Yes
133172D structureQUISQUALIC ACIDC5H7N3O5189.1276 / 3-3.9Yes
5173892D structureCHEMBL3958116C17H11F4N3O3S2445.40710 / 13.5Yes
140042D structureCHEMBL1922764C19H20ClNO2329.8243 / 05.7No
5173952D structureSCHEMBL1653189C15H10Cl2N4O3S397.235 / 12.8Yes
4593482D structureCHEMBL3930906C13H11FN4242.2574 / 22.9Yes
5174012D structureCHEMBL3974101C16H14N4O3S342.3735 / 11.9Yes
160072D structureCHEMBL300330C7H12N2O4188.1836 / 3-6.0Yes
170832D structureCHEMBL2023628C17H12N4272.3113 / 03.2Yes
4593752D structureN-(3-chlorophenyl)-1H-Pyrazolo[4,3-b]pyridin-3-amineC12H9ClN4244.6823 / 23.1Yes
4593762D structureSCHEMBL6922917C12H8Cl2N4279.1243 / 23.7Yes
190202D structureCHEMBL1922739C17H17BrN2O3377.2385 / 03.0Yes
192962D structureCHEMBL1223382C18H13Cl2N3O3S422.285 / 23.8Yes
4593862D structureSCHEMBL6923592C15H22N4258.3693 / 23.7Yes
5555572D structureSCHEMBL16607464C23H15ClN2O2386.8352 / 05.0Yes
5174272D structureCHEMBL3984173C17H13Cl2N3O3S2442.3296 / 14.1Yes
203102D structureCHEMBL319279C28H27NO5457.5266 / 32.1Yes
5364882D structureAC1N2AWGC24H24N2O4S436.5265 / 14.1Yes
5174362D structureCHEMBL3956107C17H12F3N3O3S2427.4169 / 12.8Yes
4594072D structureSCHEMBL6921970C13H9F3N4278.2386 / 23.3Yes
223952D structureCHEMBL479804C8H14N2O5218.2096 / 4-3.3Yes
5174462D structureCHEMBL3960293C19H15Cl2N3O3S2468.3676 / 14.3Yes
228602D structureCHEMBL1672235C19H15ClN4O3382.8045 / 22.4Yes
5533582D structureLSP4-2022C13H18NO8P347.269 / 5-3.8Yes
252982D structureCHEMBL549670C17H11Cl2NO2332.182 / 15.1No
5223302D structureCHEMBL3809928C16H12FN3O3S345.3485 / 12.1Yes
4594462D structureSCHEMBL2361692C12H8ClFN4262.6724 / 23.2Yes
272642D structureCHEMBL1922757C12H9ClN2O2248.6664 / 02.1Yes
275772D structureCHEMBL1922733C14H9BrCl2O2360.0282 / 05.3No
5223932D structureCHEMBL3808806C16H12ClN3O3S361.84 / 12.6Yes
4594652D structureSCHEMBL6922222C14H8F6N4346.2369 / 24.2Yes
5174712D structureSCHEMBL1653827C14H12N4O3S2348.3956 / 12.0Yes
5224592D structureCHEMBL3759867C19H11Cl2N3O4416.2145 / 13.7Yes
5224752D structureCHEMBL3800579C20H12ClN3O4393.7835 / 23.4Yes
5367692D structureCHEMBL3560146C24H24N2O5420.4655 / 13.5Yes
4667332D structureCHEMBL3628111C20H12Cl2N2O4415.2264 / 14.3Yes
4594912D structureSCHEMBL6922868C11H7ClFN5263.665 / 22.4Yes
5225062D structureCHEMBL3800490C20H14Cl2N4O2413.2584 / 23.7Yes
5174862D structureCHEMBL3972975C18H14F3N3O3S2441.4439 / 13.7Yes
5174872D structureCHEMBL3808861C18H15F2N3O3S2423.4538 / 13.5Yes
324902D structureCHEMBL2023465C26H28N4O412.5374 / 05.0Yes
4595122D structureSCHEMBL6923917C13H18N4230.3153 / 23.3Yes
4670042D structureCHEMBL3609735C13H10F2N2O2264.2325 / 12.5Yes
349702D structureCHEMBL2023470C24H24N4O2400.4825 / 03.4Yes
349722D structureVU0405622-1C20H12ClN3O3377.7844 / 13.2Yes
353382D structureCHEMBL32972C6H10NO5P207.1226 / 4-4.6Yes
354272D structureCHEMBL418462C13H15ClN2O4298.7236 / 3-3.9Yes
357472D structureCHEMBL1099112C17H11ClN2278.7392 / 04.6Yes
357852D structureBDBM50388941C16H13N3O3295.2985 / 11.4Yes
5556152D structureSCHEMBL16599137C24H17ClN2O2400.8622 / 05.4No
5175002D structureCHEMBL3904734C19H15F2N3O3S2435.4648 / 13.2Yes
4595432D structureSCHEMBL6922218C12H8ClFN4262.6724 / 23.2Yes
5175032D structureSCHEMBL1652013C19H19N5O4S413.4527 / 11.3Yes
366822D structureCID 57689797C3H8NO6P185.0726 / 3-4.5Yes
4674912D structureCHEMBL3605296C20H17N5O3375.3886 / 12.1Yes
5556162D structureSCHEMBL16599112C20H12ClN3O2S393.8454 / 04.7Yes
4677222D structureCHEMBL3634432C21H15FN2O5394.3586 / 13.1Yes
396762D structureCHEMBL2023456C18H12ClN3305.7652 / 04.4Yes
401432D structureCHEMBL1711049C19H16ClN3O3369.8054 / 12.5Yes
5227552D structureCHEMBL3809364C17H14FN3O3S359.3755 / 12.0Yes
4679782D structureCHEMBL3609731C13H11BrN2O2307.1473 / 12.7Yes
5227732D structureCHEMBL3759555C20H15ClN4O3394.8154 / 12.7Yes
4681162D structureCHEMBL3634433C19H13N3O4347.335 / 12.3Yes
5556392D structureSCHEMBL16599270C21H14F2N4O2392.3665 / 03.2Yes
449322D structureVU0080241C19H23N5321.4284 / 04.3Yes
454622D structureCHEMBL584209C14H17NO3247.2943 / 22.2Yes
4596312D structureSCHEMBL6921998C14H12F2N4O2306.2737 / 23.3Yes

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