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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameEndothelin-1 receptor
SpeciesSus scrofa (Pig)
GeneEDNRA
SynonymEndothelin receptor type A {ECO:0000250|UniProtKB:P25101}
ET-A
ET-AR
DiseaseN/A for non-human GPCRs
Length427
Amino acid sequenceMETFCFRVSFWVALLGCVISDNPESHSTNLSTHVDDFTTFRGTEFSLVVTTHRPTNLALPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFENHDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEEHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHEQNNHNTERSSHKDSIN
UniProtQ29010
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4130
IUPHARN/A
DrugBankN/A

Known ligands

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Total entries: 371
Page:  / 4 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
482D structureCHEMBL304260C49H61N7O10908.06610 / 94.7No
7712D structureCHEMBL116108C31H31N5O5S585.67910 / 16.0No
36862D structureCHEMBL72891C31H46BrN5O5S680.7036 / 56.0No
40562D structureCHEMBL113757C28H31N5O5S549.64610 / 15.3No
45752D structureCHEMBL2304007C33H44N6O7636.757 / 62.7No
50982D structureCHEMBL114700C27H28BrN5O6S630.51411 / 15.7No
85122D structureCHEMBL324304C23H27N3O4S441.5467 / 24.3Yes
101102D structureCHEMBL430515C29H33N5O6S579.67211 / 15.7No
128532D structureBDBM50287884C73H97N15O211520.6622 / 192.3No
134642D structureCHEMBL31436C25H37N5O5487.6015 / 62.2No
151952D structureCHEMBL77083C31H45N5O5567.7315 / 54.7No
181852D structureCHEMBL263186C55H65N7O10984.16410 / 96.7No
203712D structureCHEMBL404763C30H42N6O7598.7017 / 72.1No
208942D structureCHEMBL342615C30H42N6O8S646.768 / 61.6No
225152D structureCHEMBL2304014C31H39N7O7621.6958 / 61.9No
227852D structureCHEMBL281963C26H36N4O7516.5957 / 61.9No
229032D structureCHEMBL308621C32H45N7O5607.7566 / 64.0No
240132D structureCHEMBL168904C30H34BrN5O4S640.5979 / 17.2No
249312D structureCHEMBL3301647C30H40N6O7596.6857 / 63.0No
249322D structureCHEMBL138067C30H40N6O7596.6857 / 63.0No
270552D structureCHEMBL112502C25H27N5O5S2541.64111 / 14.6No
284782D structureCID 44314819C73H97N15O211520.6622 / 192.3No
306052D structureCHEMBL77853C30H42BrN5O5632.65 / 55.6No
335512D structureCHEMBL133257C33H44N6O7636.757 / 62.7No
369092D structureCHEMBL64271C51H65N7O10936.1210 / 96.1No
4432042D structureCHEMBL407831C51H63N7O12966.10212 / 104.6No
386082D structureCHEMBL114704C31H31N5O6S601.67811 / 15.8No
395232D structureCHEMBL284785C27H41N5O6531.6546 / 61.4No
396692D structureCHEMBL135906C29H40N6O8600.6738 / 81.4No
397662D structureCHEMBL287980C36H48N7O6-674.8237 / 34.2No
403682D structureCHEMBL408616C52H63N9O10974.12911 / 104.9No
409762D structureCHEMBL323243C27H28ClN5O4S554.0629 / 15.9No
427772D structureCHEMBL170493C32H31BrN6O4S675.60210 / 16.6No
433802D structureCID 23427740C34H27Br4N4NaO11S1042.2713 / 5N/ANo
446902D structureCHEMBL74471C36H45BrN6O5721.6975 / 66.5No
470032D structureCHEMBL2370830C32H44N6O7624.7397 / 62.5No
496062D structureCHEMBL321242C27H29N5O4S519.629 / 15.3No
513042D structureCHEMBL114201C27H29N5O6S551.61811 / 15.0No
543432D structureCHEMBL77033C30H44BrN5O5634.6165 / 55.7No
547022D structureCHEMBL336087C29H41N5O8587.6748 / 61.7No
549532D structureCHEMBL307324C32H44N6O7624.7397 / 52.4No
549542D structureCHEMBL138120C32H44N6O7624.7397 / 52.4No
560352D structureCHEMBL287888C33H51N5O5597.8015 / 56.0No
560372D structureCHEMBL405724C33H51N5O5597.8015 / 56.0No
569922D structureCHEMBL326380C31H31N5O4S2601.7410 / 16.6No
570432D structureCHEMBL409808C51H64N8O11965.11811 / 103.9No
628262D structureCHEMBL2304018C30H39ClN6O7631.1277 / 62.8No
635132D structureCHEMBL170663C30H36BrN7O6S702.62513 / 35.4No
636732D structureCHEMBL332922C29H33N5O4S2579.73410 / 16.3No
640272D structureCHEMBL311134C31H41N7O5591.7136 / 63.0No
642632D structureCHEMBL335128C37H45N7O7699.8097 / 83.6No
684332D structureCHEMBL116046C28H31N5O4S2565.70710 / 15.8No
686512D structureCHEMBL287676C28H35N5O5521.6185 / 63.3No
693552D structureCHEMBL312541C33H42N6O7634.7347 / 62.1No
720032D structureCHEMBL343959C26H39N7O7561.648 / 60.2No
782082D structureCHEMBL343768C29H40N6O7S616.7348 / 81.8No
789452D structureCHEMBL405100C51H65N7O10S968.1811 / 95.7No
811472D structureCHEMBL262947C55H65N7O111000.1611 / 106.3No
830412D structureCHEMBL438022C63H71N7O101086.310 / 98.4No
838232D structureCHEMBL287141C26H38N4O5486.6135 / 52.7Yes
844342D structureCHEMBL166875C28H30BrN5O6S644.54111 / 15.9No
849092D structureCHEMBL112134C27H22BrN5O4S592.4689 / 15.6No
895822D structureCHEMBL62514C46H57N7O9852.0029 / 94.2No
896262D structureCHEMBL410694C50H62N8O11951.09111 / 103.6No
902802D structureCHEMBL113927C28H31N5O6S565.64511 / 15.2No
915152D structureCHEMBL420501C26H28N6O4S2552.66811 / 14.4No
922892D structureCHEMBL302776C29H40N6O7584.6747 / 71.9No
922902D structureCHEMBL335143C29H40N6O7584.6747 / 71.9No
964622D structureCHEMBL177373C27H24BrN5O5S610.48310 / 2N/ANo
973772D structureCHEMBL362276C28H31N5O5S549.64610 / 15.3No
978142D structureCHEMBL2373085C51H63N7O10934.10410 / 85.4No
981282D structureBosentanC27H29N5O6S551.61811 / 23.8No
986102D structureCHEMBL177924C26H28BrN5O5S602.50410 / 2N/ANo
1011512D structureCHEMBL136871C31H30BrN5O4S2680.63610 / 17.4No
1013572D structureCHEMBL405916C55H65N7O111000.1611 / 106.3No
1032092D structureCHEMBL308584C31H47N5O5S601.8076 / 54.8No
1036452D structureCHEMBL151064C25H24ClNO6469.9187 / 22.6Yes
1043932D structureCHEMBL31388C27H39N5O5513.6395 / 52.3No
1070422D structureCHEMBL412602C31H46ClN5O5604.1895 / 56.2No
1070432D structureCHEMBL289410C31H46ClN5O5604.1895 / 56.2No
1099142D structureCHEMBL335126C28H36N6O10616.62810 / 9-0.5No
1102052D structureCHEMBL308403C30H44BrN5O5S666.6766 / 55.5No
1112482D structureCHEMBL343062C30H40N6O7S628.7458 / 62.2No
1113142D structureCHEMBL77468C31H46BrN5O5648.6435 / 56.3No
1120502D structureCHEMBL31051C28H35N5O5521.6185 / 62.4No
1124332D structureCHEMBL31546C30H37N5O5547.6565 / 53.1No
1124612D structureCHEMBL2304012C32H41BrN6O7701.6197 / 63.3No
1146182D structureCHEMBL341751C28H36N6O7568.6317 / 60.8No
1146192D structureCHEMBL308208C28H36N6O7568.6317 / 60.8No
1159462D structureCHEMBL136210C35H44N6O7660.7727 / 73.5No
1177132D structureCHEMBL420132C27H28ClN5O4S2586.12210 / 16.1No
1178252D structureCHEMBL1791007C31H42N6O7610.7127 / 62.2No
1180132D structureCHEMBL386778C51H63N7O12966.10212 / 104.6No
1181972D structureCHEMBL407639C29H40N6O10S664.73110 / 80.4No
1182192D structureCHEMBL175523C29H33N5O6S2611.73212 / 15.4No
1199202D structureCHEMBL216772C68H98N14O211447.6122 / 181.9No
1208822D structureCHEMBL2304010C31H41ClN6O7S677.2148 / 62.7No
1219012D structureCHEMBL262993C52H67N7O10950.14710 / 96.4No
1219052D structurePD 145065C52H67N7O10950.14710 / 96.4No
1237462D structureCHEMBL408574C48H59N7O10894.03910 / 94.3No

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