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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

Name5-hydroxytryptamine receptor 1A
SpeciesMus musculus (Mouse)
GeneHtr1a
SynonymADRBRL1
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
5-HT-1A
5-HT1A receptor
Serotonin receptor 1A
[ Show all ]
DiseaseN/A for non-human GPCRs
Length421
Amino acid sequenceMDMFSLGQGNNTTTSLEPFGTGGNDTGLSNVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSNPNECTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKKGAGTSFGTSSAPPPKKSLNGQPGSGDCRRSAENRAVGTPCANGAVRQGEDDATLEVIEVHRVGNSKGHLPLPSESGATSYVPACLERKNERTAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPELLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCR
UniProtQ64264
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3737
IUPHARN/A
DrugBankN/A

Known ligands

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Total entries: 126
Page:  / 2 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
100412D structureCHEMBL143075C20H25N5OS2415.5747 / 23.8Yes
104512D structureSB 204070 hydrochlorideC19H27ClN2O4382.8856 / 13.5Yes
5362722D structureCHEMBL3915107C21H23ClN2O3386.8764 / 03.4Yes
5575972D structureSCHEMBL14060375C21H23ClN2O3386.8764 / 03.4Yes
109772D structureEF-7412C22H33N5O4S463.5977 / 11.5Yes
136302D structureCHEMBL26998C16H25NO247.3822 / 14.1Yes
136612D structure8-OH-DpatC16H25NO247.3822 / 14.1Yes
232452D structureDIHYDREXIDINEC17H17NO2267.3283 / 32.5Yes
246942D structureCHEMBL88365C17H20N2O268.363 / 13.0Yes
320302D structureCHEMBL88160C26H34F3N7O2533.610 / 14.3No
340502D structureCHEMBL2021539C15H21ClF3NO2S371.8436 / 2N/AN/A
340532D structureCHEMBL2021524C15H21ClF3NO2S371.8436 / 2N/AN/A
5587262D structureSCHEMBL15746093C22H27N3O3381.4765 / 02.5Yes
5371872D structureCHEMBL3941579C22H27N3O3381.4765 / 02.5Yes
5484252D structureCHEMBL3935152C22H27N3O3381.4765 / 02.5Yes
5587292D structureSCHEMBL15746091C22H27N3O3381.4765 / 02.5Yes
5484272D structureCHEMBL3956749C22H27N3O3381.4765 / 02.5Yes
5587312D structureSCHEMBL15746095C22H27N3O3381.4765 / 02.5Yes
646682D structurePD-168077C20H22N4O334.4234 / 13.0Yes
5594242D structureSCHEMBL14061923C20H25N3O2339.4395 / 02.7Yes
5486932D structureCHEMBL3969837C20H25N3O2339.4395 / 02.7Yes
687812D structureSNAP-7915C25H28F3N3O3475.5127 / 15.0Yes
787322D structureCHEMBL343838C23H26N6OS434.5626 / 24.2Yes
1068022D structureCHEMBL135623C23H24FN3OS409.5235 / 24.3Yes
1118832D structureCHEMBL11388C16H23NO245.3662 / 03.6Yes
1149242D structureCHEMBL336842C23H25FN2O3S428.5227 / 13.9Yes
5492802D structureCHEMBL3930615C23H28N2O3380.4884 / 03.5Yes
5608612D structureSCHEMBL15746098C23H28N2O3380.4884 / 03.5Yes
1219842D structureCHEMBL142211C21H26N6OS410.547 / 23.4Yes
1244152D structureCHEMBL104985C14H18ClN3O279.7684 / 03.4Yes
1346902D structureCHEMBL138458C23H29NO2351.493 / 04.3Yes
5497342D structureCHEMBL3957983C21H25N3O3367.4495 / 02.1Yes
5497352D structureCHEMBL3957263C21H25N3O3367.4495 / 02.1Yes
5618252D structureSCHEMBL15746099C21H25N3O3367.4495 / 02.1Yes
5618262D structureSCHEMBL15746100C21H25N3O3367.4495 / 02.1Yes
1462182D structureGR 103691C30H35N3O3485.6285 / 14.8Yes
5497382D structureCHEMBL3960882C21H25N3O3367.4495 / 02.4Yes
5618472D structureSCHEMBL15746101C21H25N3O3367.4495 / 02.4Yes
1488522D structureCHEMBL91605C25H34FN7O2483.5928 / 13.3Yes
1573692D structureCHEMBL143447C21H26N6OS410.547 / 23.1Yes
5403722D structureCHEMBL3900699C22H26N2O4382.465 / 02.7Yes
5626582D structureSCHEMBL15746087C22H26N2O4382.465 / 02.7Yes
1736812D structureCHEMBL48100C20H23N5O3S413.4967 / 01.5Yes
1736822D structureCHEMBL49630C20H23N5O3S413.4967 / 01.5Yes
1748062D structureCHEMBL335082C23H26N2O3S410.5326 / 13.8Yes
1756642D structuresumatriptanC14H21N3O2S295.4014 / 20.9Yes
1851592D structureCHEMBL141494C21H25N5OS395.5256 / 13.2Yes
2075072D structureCHEMBL141438C20H25N5OS2415.5747 / 24.2Yes
2097252D structureUNII-2L5SGH4CVSC22H31N5O2397.5236 / 13.1Yes
2100792D structureCHEMBL128329C20H24N2O308.4252 / 13.1Yes
2276472D structureCHEMBL2021525C15H20F3NO2S335.3856 / 13.5Yes
2276512D structureCHEMBL2021538C15H20F3NO2S335.3856 / 13.5Yes
2319182D structureCHEMBL142456C24H27N5OS433.5745 / 24.4Yes
2416672D structureBDBM50078561C22H33N5O4S463.5977 / 21.4Yes
2429462D structureCHEMBL131691C24H27N3OS405.565 / 24.5Yes
2458342D structureCHEMBL420620C22H30FN5O2415.5137 / 13.2Yes
2649222D structureCHEMBL141209C21H25NO2323.4363 / 03.5Yes
5433312D structureCHEMBL3946540C21H25ClN2O2372.8934 / 04.1Yes
5657902D structureSCHEMBL14060296C21H25ClN2O2372.8934 / 04.1Yes
5658152D structureSCHEMBL14061586C21H25N3O3367.4495 / 02.4Yes
5513192D structureCHEMBL3970895C21H25N3O3367.4495 / 02.4Yes
2861492D structureCHEMBL341326C20H24N2292.4261 / 14.1Yes
2895422D structureCP-293019C19H22F2N4O360.4097 / 03.1Yes
2903032D structureserotoninC10H12N2O176.2192 / 30.2Yes
5663762D structureclozapineC18H19ClN4326.8283 / 13.1Yes
2914472D structurerisperidoneC23H27FN4O2410.4936 / 02.7Yes
2924332D structureCHEMBL339944C21H26N2306.4531 / 14.5Yes
2926382D structureCHEMBL89030C24H34N4O2410.5625 / 14.2Yes
2984732D structureCHEMBL358268C25H27N5OS445.5856 / 14.5Yes
3006262D structureCHEMBL332154C18H18N2O2294.3544 / 23.0Yes
5441142D structureCHEMBL3986651C22H28N2O3368.4775 / 03.4Yes
3017372D structureCHEMBL356743C25H31N5OS449.6176 / 24.7Yes
3092612D structureCHEMBL138809C20H23NO2309.4093 / 03.0Yes
3118272D structureCHEMBL38465C14H13N3S255.3393 / 13.1Yes
3169512D structureCHEMBL2112696C24H24FN3OS421.5346 / 14.8Yes
3206532D structureCHEMBL338310C21H26N2O322.4522 / 13.5Yes
3289852D structureCHEMBL128954C19H25NO283.4152 / 03.3Yes
3311512D structureIPSAPIRONEC19H23N5O3S401.4857 / 01.5Yes
3351542D structureCHEMBL344994C21H25N5OS395.5256 / 13.5Yes
3452152D structureCHEMBL35226C21H29N3O339.4834 / 14.5Yes
3467232D structureRS-100235C27H35ClN2O5503.0367 / 14.6No
5522802D structureCHEMBL3895206C20H23N3O3353.4225 / 02.0Yes
5681902D structureSCHEMBL14061894C20H23N3O3353.4225 / 02.0Yes
3488262D structureCHEMBL49623C21H27NO2325.4523 / 23.9Yes
3488402D structureIfenprodilC21H27NO2325.4523 / 23.9Yes
3511272D structureCHEMBL64508C15H17NO2243.3063 / 22.6Yes
3541212D structureCHEMBL141319C23H26N6OS434.5626 / 23.8Yes
3558842D structureCHEMBL142277C24H29N5OS435.596 / 24.3Yes
3590722D structureCHEMBL63449C20H28N2O312.4572 / 14.3Yes
3590752D structureCHEMBL65274C20H28N2O312.4572 / 14.3Yes
3626032D structureCHEMBL10270C16H21NO243.352 / 03.2Yes
3626082D structureCHEMBL418705C16H21NO243.352 / 03.2Yes
3626182D structureCHEMBL26118C16H21NO243.352 / 03.2Yes
3668042D structureCHEMBL141392C21H26N6OS410.547 / 23.4Yes
3789882D structureCHEMBL343228C24H27N5OS433.5745 / 24.4Yes
3796392D structureCHEMBL37170C22H27N3O349.4783 / 13.5Yes
3796432D structureCHEMBL35093C22H27N3O349.4783 / 13.5Yes
3893242D structureCHEMBL554220C14H19ClF3NO3S373.8157 / 2N/AN/A
3907242D structureCHEMBL342742C21H26N6OS410.547 / 23.1Yes
3935292D structureCHEMBL141485C20H25N5OS2415.5747 / 24.2Yes

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